Clinical Efficacy of Pathyadi Kwath Arka & Katphala Churna Nasya in the Management of Ardhavabhedaka with special reference to Migraine - A pilot Study

Ardhavabhedaka can be correlated with migraine having similar symptom as half-sided headache. It is mentioned as tridoshapradhana by Sushruta and vatakaphapradhana by Vagbhata. Pathyadi Kwath is a proven formulation for urdhwajatrugata disorders including Ardhavabheaka. In addition, importance of Nasya karma in shirogata vyadhi cann’t be ignored so here pradhamana nasya with kataphala churna mentioned in Yogaratnakara is selected to evaluate its efficacy. Aim & Objective: The present study aimed to evaluate the clinical efficacy of Pathyadi Kwath Arka & Katphala Churna Nasya in the management of Ardhavabhedaka with special reference to Migraine. Material and method: The fruit of haritaki, bibhitaki, Amalaki, stem bark of nimba, whole plant of bhunimba, rhizome of haridra and stem of guduchi were used for the preparation of Pathyadi Kwath and its extract (arka) was prepared using the same ingredients by the process of distillation. Course powder of Kataphala was prepared in grinder, then filtered from mesh size 500 micron (BS 30, ASTM 35) and smooth powder of Kataphala obtained. Botanists carried out authentication of drugs. The study conducted on 10 samples for the duration of 12 weeks. Pathyadi kwath given in the dose of 10 drops/ 10 ml of water and kataphala churna pradhaana nasya; morning and evening daily. Result: Statistically significant p value was noted i.e.(P<0.05), the null hypothesis is accepted, hence it is clear that all the parameters show a significant difference in the observations (before treatment and after treatment). Conclusion: Pathyadi Kwath Arka & Katphala Churna Nasya is effective in the management of Ardhavabhedak.

Illness characteristics of COVID-19 in children infected with the SARS-CoV-2 Delta variant

Background The Delta (B.1.617.2) SARSCoV2 variant became the predominant UK circulating strain in May 2021. Whether COVID19 from Delta infection differs to infection with other variants in children is unknown. Methods Through the prospective COVID Symptom Study, 109,626 UK school-aged children were proxy-reported between December 28, 2020 and July 8, 2021. We selected all symptomatic children who tested positive for SARS-CoV-2 and were proxy-reported at least weekly, within two timeframes: December 28, 2020 to May 6, 2021 (Alpha (B.1.1.7) the main UK circulating variant); and May 26 to July 8, 2021 (Delta the main UK circulating variant). We assessed illness profiles (symptom prevalence, duration, and burden), hospital presentation, and presence of long (>28 day) illness; and calculated odds ratios for symptoms presenting within the first 28 days of illness. Findings 694 (276 younger [5 11 years], 418 older [12 17 years]) symptomatic children tested positive for SARS-CoV-2 with Alpha infection and 706 (227 younger and 479 older) children with Delta infection. Median illness duration was short with either variant (overall cohort: 5 days (IQR 2 9.75) with Alpha, 5 days (IQR 2 9) with Delta). The seven most prevalent symptoms were common to both variants. Symptom burden over the first 28 days was slightly greater with Delta compared with Alpha infection (in younger children, 3 (IQR 2 5) with Alpha, 4 (IQR 2 7) with Delta; in older children 5 (IQR 3 8) with Alpha and 6 (IQR 3 9) with Delta infection in older children). The odds of several symptoms were higher with Delta than Alpha infection, including headache and fever. Few children presented to hospital, and long illness duration was uncommon, with either variant. Interpretation COVID-19 in UK school-aged children due to SARSCoV2 Delta strain B.1.617.2 resembles illness due to the Alpha variant B.1.1.7., with short duration and similar symptom burden.

Isolasi, identifikasi dan karakterisasi penyebab penyakit bercak daun pada semai pinus di perum perhutani BKPH Purworejo, KPH Kedu Selatan

Pinus merkusii, a multiuse tree, is cultivated at Indonesian Plantation. Pinus plantation have been threatened by rust/spot leaf disease. The pathogen has infected pinus seedlings at Perum Perhutani, BKPH Purworejo, KPH Kedu Selatan and cause high mortality. The aims of this research to identify pathogen causing rust/spot leaf thus information how to control can be observed. Pathogens were isolated from infected leaves, and grown on the potato dextrose agar (PDA) and observed macroscopis and microscopis and identified. The pathogens also were inoculated to healthy seedlings (Postulat Koch Test). The result shows that pathogen causing rust/spot leaf on seedlings pine is Pestalotia sp with characteristic white colony, hypha has aservuli with conidia that have 25 septums and at the edge, some structure looks like feather whipped 3-5. Potulat Koch test indicated that inoculated healthy seedling shows similar symptom with infected seedlings. Rust/spot leaf has similar sympto and sign. Spot or rust appear on leaves started from edge and spread to base. At first, spots were formed in small size and separate each other but they developed and became larger and wider and fused.

Vertebroplasty for Osteoporotic Spinal Fractures

This chapter, found in the back pain section of the book, provides a succinct synopsis of a key study examining the use of vertebroplasty for osteoporotic spinal fractures. This summary outlines the study methodology and design, major results, limitations and criticisms, related studies and additional information, and clinical implications. For patients with pain from fractures of less than 1 year duration, vertebroplasty brings similar symptom and quality of life improvements as a simulated vertebroplasty. In addition to outlining the most salient features of the study, a clinical vignette and imaging example are included in order to provide relevant clinical context.

Non-voice-related throat symptoms: comparative analysis of laryngopharyngeal reflux and globus pharyngeus scales

Background:This study calculated the comparability of two throat symptom assessment scales devised to evaluate either laryngopharyngeal reflux or globus.Setting:United Kingdom hospital out-patient departments.Method:A total of 334 subjects, with and without throat symptoms, completed the Reflux Symptom Index and/or the Glasgow and Edinburgh Throat Scale. The following were calculated for the resultant data: Cronbach's α coefficient, principal component analysis, Kaiser normalisation, varimax and oblimin rotation, and eigenvalues.Results:Analysis of data from the Reflux Symptom Index and the Glasgow and Edinburgh Throat Scale revealed clearly similar symptom domains regarding (1) coughing and blockage, and (2) globus or postnasal drip or throat-clearing, as did combined analysis of their amalgamated items. Both instruments had good overall internal consistency (α = 0.75 and 0.81, respectively). The ‘heartburn or reflux’ item in the Reflux Symptom Index mapped poorly to each underlying factor.Discussion:The most commonly used laryngopharyngeal reflux and globus assessment questionnaires appear to detect very similar symptom clusters. The management of throat disorders may previously have been over-reliant on the presenting pattern of throat symptoms. Our findings indicate a need to revisit the traditional clinical classification of throat symptoms.

A Prospective Study of Panic and Anxiety in Agoraphobia with Panic Disorder

The features of panic and anxiety in the natural environment were studied by prospective self-monitoring in 39 patients with chronic agoraphobia and panic disorder. Panics overlapped greatly with anxiety episodes but were more intense. Panics occurred more often in public places than did anxiety episodes, but had otherwise similar symptom profile, time of occurrence, and antecedents. Most panics surged out of a pre-existing plateau of tonic anxiety which lasted most of the day. Spontaneous panics were less frequent than situational panics and occurred more often at home but were otherwise similar. These findings do not support the sharp distinction between panic and anxiety in DSM–III–R, not its emphasis on spontaneous panic in classifying anxiety disorders. Thoughts of dying and ‘going crazy’/losing control accompanied only a minority of panic/anxiety episodes and seemed to be a product of intense panic rather than a cause.

Bronchial Provocation in the Study of Sensations Associated with Disordered Breathing

1. Lung volumes, airway resistance and flow/volume curves were measured in ten asthmatic subjects at times when tightness in the chest was just sensed (threshold symptom). 2. These measurements when the threshold symptom was induced by methacholine inhalation were compared with those when a similar symptom occurred spontaneously, in the same subjects. 3. Values during the methacholine-induced thresholds were very similar to those observed when threshold symptoms developed spontaneously. 4. Controlled bronchial provocation mimics spontaneous asthma sufficiently well to allow this technique to be used in the study of sensations associated with breathing. This has some advantages over the already established models utilizing external hindrances to breathing.