Metal-free approach for hindered amide-bond formation with hypervalent iodine(iii) reagents: application to hindered peptide synthesis

A new, bulky amide and peptide synthesis with hypervalent iodine(iii) reagent/pyridine–hydrogen fluoride complex under mild and metal-free conditions was developed by using α-amino esters with potential activating group (PAG) at the ester residue.

Hydrogen-bonded nickel(i) complexes

Secondary-sphere hydrogen bonds enable structural characterization and evaluation of an unusual nickel(i) fluoride complex.