How much progress have we made?: a 20-year experience regarding esophageal stents for the palliation of malignant dysphagia

Summary Esophageal stents are widely used for the palliation of malignant esophageal obstruction. Advances in technology have made esophageal stenting technically feasible and widespread for such obstruction, but complications remain frequent. We present outcomes of a large cohort undergoing esophageal stent placement for malignant esophageal obstruction at a tertiary care cancer center. Patients who underwent placement of esophageal stents for malignancy-related esophageal obstruction between 1 January 2001 and 31 July 2020 were identified. Exclusion criteria included stents placed for benign stricture, fistulae, obstruction of proximal esophagus (proximal to 24 cm from incisors), or post-surgical indications. Patient charts were reviewed for demographics, procedure and stent characteristics, complications, and follow-up. A total of 242 patients underwent stent placement (median age: 64 years, 79.8% male). The majority, 204 (84.3%), had esophageal cancer. During the last two decades, there has been an increasing trend in the number of esophageal stents placed. Though plastic stents were previously used, these are no longer utilized. Complications are frequent and include early complications of pain in 68 (28.1%) and migration in 21 (8.7%) and delayed complications of recurrent symptoms of dysphagia in 46 (19.0%) and migration in 26 (10.7%). Over the study period, there has not been a significant improvement in the rate of complications. During follow-up, 92 (38%) patients required other enteral nutrition modalities after esophageal stent placement. No patient, treatment, or stent characteristics were significantly associated with stent complication or outcome. Esophageal stent placement is an increasingly popular method for palliation of malignant dysphagia. However, complications, particularly pain, migration, and recurrent symptoms of dysphagia are common. Almost 40% of patients may also require other methods of enteral access after esophageal stent placement. Given the high complication rates and suboptimal outcomes, removable stents should be considered as first-line in the case of poor palliative response.

Removal of Migrated Esophageal Stents in the Stomach Under the Guidance of Fluoroscopy: a Single-center Retrospective Study

Background: Migrated esophageal self-expandable metal stents (SEMSs) increase the risk of bowel obstruction or perforation. The endoscopic removal of migrated stents is extremely difficult due to the inability to observe the distal end of the stent during retrieval. Here, we report our experience removing migrated esophageal stents in the stomach under the guidance of fluoroscopy.Material and methods: The clinical data of patients with esophageal stents that migrated to the stomach between January 2016 and March 2020 were analyzed retrospectively. A total of 27 patients (9 females and 18 males) were included in this study. Three methods of retrieval were considered: direct removal via a fixed string, direct removal via a retrieval hook, and retrieval via guide wire and gooseneck snare.Results: A total of 28 migrated esophageal stents in the stomachs of 27 patients were successfully removed under the guidance of fluoroscopy by the three methods mentioned above: 10 cases of direct removal via a fixed string, 14 cases of direct removal via a retrieval hook, and 3 cases of retrieval via a guide wire. The stent removal time was 18 (7-60) minutes. During the operation, one patient had a small amount of esophageal bleeding that was cured after symptomatic treatment, and one patient had a residual fracture stent wire that was removed under endoscopy.Conclusion: The removal of migrated esophageal stents in the stomach under the guidance of fluoroscopy is a feasible and safe procedure.

Palliative endoscopic spray cryotherapy to prevent worsening of dysphagia and improve quality of life in esophageal cancer.

219 Background: Patients with locally advanced esophageal cancer can have progressive dysphagia and associated worsening quality of life (QOL). Maintenance of esophageal patency by reducing intraluminal tumor burden can improve QOL by palliating dysphagia and delay or prevent the need for feeding tubes and esophageal stents. We aimed to assess the effect of endoscopic palliative cryoablation with trūFreeze Spray Cryotherapy (SCT) on dysphagia burden, QOL, and survival in patients with esophageal cancer. Methods: This is a multi-center prospective study of esophageal cancer patients at 10 sites in the United States. Subjects are 18-89 years old with luminal esophageal cancer, non-surgical candidates, not receiving systemic therapy, without esophageal stents, or history of prior SCT for esophageal cancer. SCT is an endoluminal ablation modality using non-contact medical grade liquid nitrogen (LN2) reaching a temperature of -1960 C delivered by a catheter. SCT was performed at 6 week intervals or as clinically indicated at a dose of 2x30 or 3x30 seconds per every 2-3 cm treatment site. Dysphagia and QOL were assessed with the 5-point Dysphagia score and EORTC QLQ 30 and OES18 esophageal module. Results: Of 49 subjects, mean age is 74.2 ± 11.8, 88% are men, 92% have esophageal adenocarcinoma and 19% have prior esophageal surgery or esophagectomy. 75% had a history of chemotherapy and/or radiation, and 58% (n=21) had a tumor stage >2. Subjects had a total of 258 treatment sessions over a mean follow-up of 329.7 ± 219.1 days, and received a median of 4 (IQR:2-7) SCT sessions with an average dose of 90 (3x30 sec) seconds/treatment site. There were 19 procedure related adverse events (20.4% of patients and 7.4% of procedures), all of which were mild (n=13) or moderate (n=6) in severity. Mean baseline dysphagia score was 1.7 ± 0.9 and 89% maintained (72%) or improved (17%) their baseline dysphagia score after initial SCT, p<0.05, and maintained this degree of symptom burden with ongoing SCT for a mean 239 ± 198 days. 28.6% (n=14) needed an esophageal stent after a mean 168 ± 169 days and 8% (n=4) had a feeding tube placed after a mean 145 ± 76 days after initial treatment. There was improvement in global health status (61.9 ± 23.3 vs 67.7 ± 19.7) and social functioning (73.9 ± 24.7 vs 81.2 ± 28.0) with decreased dysphagia (OES18: 21.5 vs. 16.7) and eating problems (26.1 vs. 20.6), p<0.05 for all. During the follow-up period, 49% of this palliative group survived and median survival was 386 days. Factors associated with survival with SCT were earlier cancer stage (69% stage 1 or 2 were survivors vs. 20% non-survivors; p=0.03) and ≤25% of luminal obstruction by tumor (62% vs. 36%; p=0.06). Conclusions: Liquid nitrogen SCT is an effective option to curb dysphagia progression in palliation of esophageal cancer and improves overall quality of life. Degree of luminal obstruction and tumor stage predicted survival. Clinical trial information: NCT03243734.

Endoscopic management of anastomotic leak after esophageal or gastric resection for malignancy: a multicenter experience

Background: Most anastomotic leaks after surgical resection for esophageal or esophagogastric junction malignancies are treated endoscopically with esophageal stents. Internal drainage by double pigtail stents has been used for the endoscopic management of leaks following bariatric surgery, and recently introduced for anastomotic leaks after resections for malignancies. Our aim was to assess the overall efficacy of the endoscopic treatment for anastomotic leaks after esophageal or gastric resection for malignancies. Methods: We conducted a multicenter retrospective study in four digestive endoscopy tertiary referral centers in France. We included consecutive patients managed endoscopically for anastomotic leak following esophagectomy or gastrectomy for malignancies between January 2016 and December 2018. The primary outcome was the efficacy of the endoscopic management on leak closure. Results: Sixty-eight patients were included, among which 46 men and 22 women, with a mean ± SD age of 61 ± 11 years. Forty-four percent had an Ivor Lewis procedure, 16% a tri-incisional esophagectomy, and 40% a total gastrectomy. The median time between surgery and the diagnosis of leak was 9 (6–13) days. Endoscopic treatment was successful in 90% of the patients. The efficacy of internal drainage and esophageal stents was 95% and 77%, respectively ( p = 0.06). The mortality rate was 3%. The only predictive factor of successful endoscopic treatment was the initial use of internal drainage ( p = 0.002). Conclusion: Endoscopic management of early postoperative leak is successful in 90% of patients, preventing highly morbid surgical revisions. Internal endoscopic drainage should be considered as the first-line endoscopic treatment of anastomotic fistulas whenever technically feasible.