copy number status
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2020 ◽  
Author(s):  
Ramakanth Chirravuri-Venkata ◽  
Dario Ghersi ◽  
Apar K. Ganti ◽  
Imayavaramban Lakshmanan ◽  
Sanjib Chaudary ◽  
...  

AbstractThe contrast in therapy sensitivity and response across triple negative breast cancer (TNBC) patients suggest underlying genotypic heterogeneity. Using publicly available data, we found significant associations between DNA-level copy number alterations of 1q21.3 locus and therapy sensitivity. We show that in spite of their aggressive nature, 1q21.3 amplified tumors are more responsive to commonly used cytotoxic therapies, highlighting the relevance of 1q21.3 copy number status as a genetic marker for risk stratification, therapy selection and response.


PLoS ONE ◽  
2017 ◽  
Vol 12 (6) ◽  
pp. e0178351 ◽  
Author(s):  
Felipe Andreiuolo ◽  
Gwénaël Le Teuff ◽  
Mohamed Amine Bayar ◽  
John-Paul Kilday ◽  
Torsten Pietsch ◽  
...  

Oncotarget ◽  
2016 ◽  
Vol 8 (1) ◽  
pp. 1046-1057 ◽  
Author(s):  
Stephan Macher-Goeppinger ◽  
Martina Keith ◽  
Volker Endris ◽  
Roland Penzel ◽  
Katrin E. Tagscherer ◽  
...  

2016 ◽  
Vol 20 (1) ◽  
pp. 126-135 ◽  
Author(s):  
Katsutoshi Shoda ◽  
Daisuke Ichikawa ◽  
Yuji Fujita ◽  
Kiyoshi Masuda ◽  
Hidekazu Hiramoto ◽  
...  

Genomics ◽  
2014 ◽  
Vol 104 (4) ◽  
pp. 271-278 ◽  
Author(s):  
Christopher Veigaard ◽  
Eigil Kjeldsen

2014 ◽  
Vol 464 (5) ◽  
pp. 547-551 ◽  
Author(s):  
Diana Boehm ◽  
Wenzel Vogel ◽  
Alina Franzen ◽  
Andreas Schrock ◽  
Friedrich Bootz ◽  
...  

PLoS ONE ◽  
2012 ◽  
Vol 7 (8) ◽  
pp. e42682 ◽  
Author(s):  
Carles Garcia-Linares ◽  
Jaume Mercadé ◽  
Bernat Gel ◽  
Josep Biayna ◽  
Ernest Terribas ◽  
...  

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