Materials for pharmacology hydrastinine.

The author made experiments both on frogs and warm-blooded animals; the first examined the General effect of hydrastinine, and then its effect on the nervous system, blood and lymph circulation; to warm-blooded-well, after reading General effect, we studied the influence on the circulatory system and the uterus.

CHANGES IN LIVER LYMPH CIRCULATION IN DEPEND OF THE DURATION OF INHALATION INTOXICATION BY VAPORS OF HYDROGEN CHLORIDE IN THE EXPERIMENT

The aim of investigation was to study changes in liver lymph circulation with intoxication by the respiratory route. The lymph circulation is estimated depending on the speed of the lymph flow and the time of its formation. The study was conducted on 16 rabbits of the chinchilla. A model of intoxication was created on 12 rabbits by inhalation of HCl vapors. It is determined that in the first 10 days of toxicosis the lymph flow is accelerated, and the period of formation becomes faster. As increasing the periods of intoxication in the dynamics of these indicators has slowed. Also the increasing of period of toxemia leads to a deepening of changes in lymph circulation. An obvious relationship between the duration of toxicosis and the lymphatic circulation of the liver is determined. We believe that the attenuation of the detoxification function of the liver should be regarded as part of the chain of pathogenesis.

SURGICAL TREATMENT OF PATIENTS WITH CANCER OF THE VULVA

The article presents historical aspect of radical surgical treatment of patients with cancer of the vulva from the beginning of the XX century to nowadays. Article presents positive and negative aspects of different surgical techniques in reconstructive plastic component and lymph circulation paths. Question about conducting the inguinal-femoral lymphadenec-tomy always evoked mixed controversial disputes various authors, which leads to index decline or rejection of this type of operation.

Physiology and pathophysiology of the lymphatic system. Research results and further prospects

The review summarizes own research and literature on the role of the lymphatic system in a number of physiological and pathological conditions. The typical reaction of lymph circulation seen in shock, acute diffuse peritonitis, in postoperative period is the lymph flow volumetric rate increase. Mobilization of the lymphatic system, extravascular fluid and proteins in well-studied emergencies is explained considering the role of the lymphatic system as a natural source of circulating blood volume regulation and serum proteins replacement («autotransfusion»). These pathological processes are associated with progression of lymphatic failure on the late terms. The principle of lymph circulation targeted stimulation as a way to detoxify the body using hormones and procaine (Novocain) blockade of splanchnic nerves and the borderline sympathetic trunks was proposed based on modeled acute peritonitis. Increased microcirculation and central lymph flow, alterations in resorption, transport and filtration barrier function of the lymphatic system, as well as morphologic and functional reorganization of the lymph nodes were revealed in fever of different duration. Of particular interest are studies on the role of the lymphatic system in the immediate and long-term body adaptation to physical stress. Activation of central lymph circulation in adequate dynamic loads correlated with changes in the system lymph microcirculation (acceleration of lymph flow, increased peristalsis of the lymph microvessels walls and contractile activity of their valves). Extreme physical exhaustion was accompanied by expressed lymphovascular, extravascular and intravascular changes in the microvasculature. Lymphatic failure, as well as structural microcirculation impairments in a trained body occur only in extreme physical stress. Thus, the lymphatic system is involved in many physiological and pathological processes; its functional condition affects the course and outcome of the disease. Therefore, the treatment of the diseases requires, among other measures, correction of lymph formation and circulation (stimulation or inhibition, endolymphatic treatment, thoracic duct drainage, lymphosorption, blockade of nodal pathways and other methods - depending on the specific disease).