Medial Pedicle Pivot Point Using Preoperative Computed Tomography Morphometric Measurements for Cervical Pedicle Screw Insertion: A Novel Technique and Case Series

This study describes a new and safe freehand cervical pedicle screw insertion technique using preoperative computed tomography (CT) morphometric measurements as a guide and a medial pedicle pivot point (MPPP) during the procedure. This study included 271 pedicles at 216 cervical spine levels (mean: 4.75 pedicles per patient). A pedicle diameter (PD) ≥ 3.5 mm was the cut-off for pedicle screw fixation. The presence and grade of perforation were detected using postoperative CT scans, where perforations were graded as follows: 0, no perforation; 1, perforation < 0.875 mm; 2, perforation 0.875–1.75 mm; and 3, perforation > 1.75 mm. The surgical technique involved the use of an MPPP, which was the point at which the lines representing the depth of the lateral mass and total length of the pedicle intersected, deep in the lateral mass. The overall success rate was 96.3% (261/271, Grade 0 or 1 perforations). In total, 54 perforations occurred, among which 44 (81.5%) were Grade 1 and 10 (18.5%) were Grade 2. The most common perforation direction was medial (39/54, 72.2%). The freehand technique for cervical pedicle screw fixation using the MPPP may allow for a safe and accurate procedure in patients with a PD ≥3.5 mm.

Eccentric and Concentric Motion Motion of Hamstring during the Leg Curl

The force experienced by the hamstring during the leg curl has been numerically investigated using the conservation theorem. The center of the meniscus is assumed to be the pivot point along with the uniform distribution of forces in the frictionless environment. The variation of force experienced by the hamstring during the concentric motion of the leg curl has been derived and graphically illustrated. It is found that the force experienced by the hamstring increases with the increase in length of the lower leg and its weight as well. The magnitude of force decreases with the increase in distance from the pivot to insertion. However, the magnitude of force increases from about 3.60 to 4.79 kN in the practically valid region 3 to 4 cm distance from the pivot to insertion with the increase in weight of lower leg from 5 to 15 kg. On the other hand, the magnitude of force increases from about 3.75 to 9.80 kN with the increase in weight suspended on the machine from 10 to 40 kg. In addition, the force decreases with the increase in upper leg dimension, but it linearly increases with the increase in the angle of suspension.

Effects of embedding depth and load eccentricity on lateral response of offshore monopiles in dense sand: A centrifuge study

Two model piles with outer diameter D = 50 mm are loaded laterally at 100×g in a large-beam geotechnical centrifuge. The normal strains on both the tensile and compressive sides are measured using fibre Bragg gratings. An incremental method is introduced to define the pivot point. The testing and analytical program enables the effect of the embedding depth and load eccentricity to be quantified. The key findings are as follows. 1) The piles generate asymmetric tensile and compressive strains during bending, and the tension-compression asymmetry becomes more pronounced at the pile toe and for shorter piles. 2) The piles transition from flexure to rotation as the embedding depth is decreased from 9D to 3D, where the uniqueness of the ground-level rotation and deflection (θg–yg) relationship disappears. 3) The reaction and deflection (P–y) relationship flattens with increasing embedding depth but seems independent of the load eccentricity.

Lateral Stability Performance of Articulated Narrow-Track Tractors

A tractor losing lateral stability starts to rollover. It is a matter of fact that tractor lateral rollover accidents are one of the most frequent causes of death and injuries for farmers. Consequently, tractors are fitted with a specific protective structure to minimize the consequences for the driver during the rollover (ROPS). The narrow-track tractor, designed to operate in vineyards and orchards, is a tractor category with a very narrow track width and the risk of rollover is higher. The aim of the study was to evaluate the compact narrow-track tractor types commercially available, designed to mount a cantilever engine in the forward position with effects on the Center of Gravity (CoG) because more than 50% of the tractor weight is loaded on the front axle, and, specifically, the articulated narrow-track tractors where the stability is affected by the pivot point connecting the two tractor bodies. As a consequence of the typical tractor design of articulated tractors, during the steering action the line passing through the front and rear tire contact points on the ground changes, influencing the tractor’s stability. The approach of the research was based on reproducing the lateral stability tractor condition by developing a kinematic model, with the goal to virtually simulate the tractor behavior and to calculate the lateral stability angle for articulated tractors. The innovative contribution of this paper was the tractor articulation joint modeling, assuming a virtual pivot point to reproduce two relatives’ rotations between the front and rear bodies of the tractor: vertical (yaw angle) and longitudinal (roll angle) rotations. The lowest value of the stability angle was 39.3°, measured at −35° yaw angle. The model at the tractor design stage will allow adjusting of the tractor parameters to improve the lateral stability performance.

Analisis Kinerja Algoritma Naive Bayes dalam Mendeteksi Sinyal Menggunakan Metode Principal Component Analysis

Melakukan analisis teknikal saat trading sangatlah penting agar terhindar dari kerugian. Penelitian ini bertujuan untuk memberi referensi tambahan kepada para trader dalam pengambilan keputusan, khususnya untuk saham PT. Resource Alam Indonesia Tbk (KKGI). Penelitian ini merupakan analisis teknikal yang menggunakan enam indikator yaitu Bollinger Band, MACD, Pivot Point, ADX, CCI, dan Stochastic. Setiap indikator memiliki beberapa atribut, jumlah keseluruhan atribut dari keenam indikator adalah 36. Untuk mereduksi data yang tidak begitu penting, penelitian ini menerapkan metode Principal Component Analysis (PCA). Kemudian data diproses menggunakan algoritma klasifikasi Naive Bayes pada perangkat lunak Weka 3.8 sehingga menghasilkan sinyal buy/sell. Hasil yang didapat dari penelitian ini yaitu berkas model yang optimal untuk mendeteksi sinyal jual/beli. Model ini berguna bagi para trader dalam mengambil keputusan untuk mendapatkan keuntungan maksimal.Kata kunci : Analisis Teknikal, Naive Bayes, Principal Component Analysis, Weka

Activation of the CaMKII-Sarm1-ASK1 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria

Mitochondrial defects are tightly linked to axon degeneration, yet the underlying cellular mechanisms remain poorly understood. In C. elegans, PVQ axons that lack mitochondria degenerate spontaneously with age. Using an unbiased genetic screen, we found that cell-specific activation of CaMKII/UNC-43 suppresses axon degeneration due to loss of mitochondria. Unexpectedly, CaMKII/UNC-43 protects against degeneration through the conserved Sarm1/TIR-1-ASK1/NSY-1 MAPK pathway. In addition, we show that disrupting a trafficking complex composed of calsyntenin/CASY-1, Mint/LIN-10, and kinesin suppresses axon degeneration. Further analysis indicates that disruption of this trafficking complex activates the CaMKII-Sarm1-MAPK pathway through L-type voltage-gated calcium channels. Our findings identify CaMKII as a pivot point between mitochondrial defects and axon degeneration, describe how it is regulated in this context, and uncover a surprising neuroprotective role for the Sarm1-ASK1 pathway.

Fluid–Structure Interaction of Symmetrical and Cambered Spring-Mounted Wings Using Various Spring Preloads and Pivot Point Locations

The fluid–structure interaction of a pivoting rigid wing connected to a spring and subjected to freestream airflow in a wind tunnel is presented. Fluid–structure interactions can, on the one hand, lead to undesirable aerodynamic behaviour or, in extreme cases, to structural failure. On the other hand, improved aerodynamic performance can be achieved if a controlled application within certain limitations is provided. One application is the reduction of drag of road vehicles at higher speeds on a straight, while maintaining downforce at lower speeds during cornering. Conversely, another application concerns increased downforce at higher windspeeds, enhancing vehicle stability. In our wind tunnel experiments, the angle of incidence of the spring-mounted wing is either increased or decreased depending on the pivot point location and spring torque. Starting from a specified initial angle, the aerodynamic forces overcome a pre-set spring preload at incrementally increased freestream velocity. Reynolds numbers at a range of Re = 3 × 104 up to Re = 1.37 × 105 are considered. The application of a symmetrical NACA 0012 and a cambered NACA 6412 airfoil are tested in the wind tunnel and compared. For both airfoils mounted ahead of the aerodynamic centre, stable results were achieved for angles above 15 and below 12 degrees for the symmetrical airfoil, and above 25 and between 10 and −2 degrees for the cambered airfoil. Unsteady motions were observed around the stall region for both airfoils with all spring torque settings and also below −2 degrees for the cambered airfoil. Stable results were also found outside of the stall region when both airfoils were mounted behind the aerodynamic centre, although the velocity ranges were much smaller and highly dependent on the pivot point location. An analysis is reported concerning how changing the spring torque settings at each pivot point location effects performance. The differences in performance between the symmetrical and cambered profiles are then presented. Finally, an evaluation of the systems’ effects was conducted with conclusions, future improvements, and potential applications.