planar lipid membrane
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2017 ◽  
Vol 112 (3) ◽  
pp. 185a
Author(s):  
Sergio Couoh-Cardel ◽  
Yi-Ching Hsueh ◽  
Stephan Wilkens ◽  
Liviu Movileanu

2012 ◽  
Vol 23 (15) ◽  
pp. 2930-2942 ◽  
Author(s):  
Tomohiro Yorimitsu ◽  
Ken Sato

COPII-coated buds are formed at endoplasmic reticulum exit sites (ERES) to mediate ER-to-Golgi transport. Sec16 is an essential factor in ERES formation, as well as in COPII-mediated traffic in vivo. Sec16 interacts with multiple COPII proteins, although the functional significance of these interactions remains unknown. Here we present evidence that full-length Sec16 plays an important role in regulating Sar1 GTPase activity at the late steps of COPII vesicle formation. We show that Sec16 interacts with Sec23 and Sar1 through its C-terminal conserved region and hinders the ability of Sec31 to stimulate Sec23 GAP activity toward Sar1. We also find that purified Sec16 alone can self-assemble into homo-oligomeric complexes on a planar lipid membrane. These features ensure prolonged COPII coat association within a preformed Sec16 cluster, which may lead to the formation of ERES. Our results indicate a mechanistic relationship between COPII coat assembly and ERES formation.


2010 ◽  
Vol 1797 ◽  
pp. 45-46
Author(s):  
Kazuhito V. Tabata ◽  
Ken Sato ◽  
Toru Ide ◽  
Takayuki Nishizaka ◽  
Akihiko Nakano ◽  
...  

2009 ◽  
Vol 28 (21) ◽  
pp. 3279-3289 ◽  
Author(s):  
Kazuhito V Tabata ◽  
Ken Sato ◽  
Toru Ide ◽  
Takayuki Nishizaka ◽  
Akihiko Nakano ◽  
...  

2009 ◽  
Vol 96 (3) ◽  
pp. 28a
Author(s):  
Hao Ding ◽  
Joseph A. Schauete ◽  
Duncan G. Steel ◽  
Ari Gafni

2007 ◽  
Vol 129 (42) ◽  
pp. 12608-12609 ◽  
Author(s):  
Kei Funakoshi ◽  
Hiroaki Suzuki ◽  
Shoji Takeuchi

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