Fork-shaped Paper SERS Sensor Coated with Raspberry-like Bimetal Nanospheres for Boosted Mixture Detection: Experimental Design and Application

Integration of SERS-active enhanced agents with the functional supporting substrate of paper to expand the application of SERS technology has attracted wide attention. However, it is still highly desired to...

Single Chemical Sensor for Multi-Analyte Mixture Detection and Measurement: A Review

Multi-analyte chemical sensor aims to transform subtle variations in multiple analytes’ physical or chemical properties into distinct output signals. Chemically responsive nanostructure array (nanoarray) promises as a competitive sensor platform due to its robust physical properties, tunable chemical composition, and high surface area for analyte interaction. Specifically, the well-defined size, shape, and tunable surface structure and properties make it feasible to develop either new sensing modes on single device or integrated multi-modular sensors. In conjunction with the well-developed resistor-type sensors and sensor arrays, the complementary utilization of and intercorrelation with the electrochemical, optical, voltammetry modes in the multi-modular sensing strategies could provide multi-dimensional measurements to different analytes in a complex mixture form, where species information could be accurately and robustly separated from spatially collective responses. This review intends to provide a survey of the recent progress on multi-analyte sensing strategies and their unique structure design, as well as the related sensing mechanics in interaction of analytes and sensitizer and the behind mechanism for analytes’ differentiation.