Assessment of Changes in the Level of Somatotropic Hormone, Cortisol and Blood Glucose in Adolescents With Meningitis of Different Etiology

This article provides a comparative description of changes in the level of growth hormone and blood cortisol in adolescents with the development of meningitis of various etiologies. The study was conducted in 2019 on 48 patients aged 10 to 19 years. In comparison, the groups of patients with acute bacterial and serous meningitis are presented. The results of the study help to determine what metabolic disorders can occur with meningitis of various etiological agents, which aggravates the course of the disease, increases the risk of complications and death, as well as to build a tactics of treatment and management of such patients. Particular attention is paid to the development of stress hyperglycemia — a condition that significantly aggravates the course of a generalized infectious and inflammatory process and increases the risk of complications from many body systems.

Gender features of adaptation of healthy test volunteers to the conditions of 120-day isolation in a hermetic object

Introduction. The occurrence of psychological problems in space flight can have a negative impact on the physiological reactions of the cosmonaut's body. The paper presents the gender features of adaptation of 6 international crew members to the conditions of 120-day isolation in a hermetic object in the "SIRIUS 18/19" project. The aim of study is to research the gender features of adaptation of test volunteers to the conditions of 120 - day isolation in a hermetic object in the "SIRIUS 18/19" experiment. Materials and methods. Psychological testing of experimental participants and determination of serum concentrations of cortisol, aldosterone, somatotropic hormone, total testosterone and prolactin were performed. Results. All participants in the "SIRIUS 18/19" experiment showed symptoms of stress. Despite the relatively stable hormonal background in women during isolation, they were more likely to experience psychological discomfort. Their personal adaptive potential decreased significantly more than in men. Conclusions. Due to their psychological and physiological characteristics, it was more difficult for women to adapt to the conditions of 120-day isolation in a hermetic facility.

Insulin-like growth factor and its dynamics in babies born from mothers with obesity

Insulin-like growth factor is one of the regulators of fetal growth in the intrauterine period, and is responsible for its further development. Purpose. To study postnatal growth in relation to insulin-like growth factor-1 and somatotropic hormonelevels in infants born to obese mothers. Materials and methods. The prospective study included 18 children (16 full-term and 2 premature infants of gestational age 31-35 weeks) born to mothers who were obese before pregnancy (group 1) and 18 children (17 full-term and 1 premature baby of gestational age 34 weeks) from mothers with normal body mass index before pregnancy. Weight and height were estimated at birth, at 3 and 6 months. Serum levels of insulin-like growth factor-1 and somatotropic hormonewere determined by ELISA at birth in umbilical cord blood at 3, 6 and 12 months. Results. During the neonatal period, at 3 and 6 months, height and weight did not have significant differences in both groups. At the age of 1 year in group 1 weight and height were higher than in group 2 (p < 0.05). Indicators of insulin-like growth factor-1 (128.71 ± 74.29 and 21.33 ± 15.21 ) and somatotropic hormone (4.3 ± 1.5 and 1.84 ± 0.36) was also higher in children of group 1 aged 1 year. Conclusion. Changes in the somatotropic hormone – insulin-like growth factor-1 axis in children born to obese mothers may form the basis of metabolic syndrome in the future.

The effect of normobaric hypoxia on the secretion of insulin and growth hormone

Effect of normobaric hypoxia on insulin (IRI) and somatotropic hormone (STH) secretion was studied in 24 normal subjects aged 35-55 years. Control group consisted of 18 subjects administered placebo. Adaptation to normobaric hypoxia was attended by changes in IRI and STH but not in the glycemia level. Hypoxic exposure was associated with an increase of the plasma STH concentration and a tendency to normalization of IRI in all examinees. These parameters correlated with body weight index.

Hypopituitarism in children and adolescents

Growth is one of the most important indicators of child health. This article focuses on hypopituitarism, an endocrine disease with isolated growth hormone deficiency (somatotropic hormone) or multiple deficiency of the pituitary tropic hormones. The authors describe the etiology, genetic mechanisms of the disease development and provide the classification. The clinical picture and its variants, the diagnostic search are described in detail, and the criteria of referral to the endocrinologist are given. A separate chapter is devoted to the detailed discussion of stimulation samples, criteria for samples selection and scheduling. The authors also raise an issue of retesting. The scheme of treatment of hypopituitarism in accordance with domestic and foreign standards is provided. A list of necessary examinations in the framework of observation of a child with hypopituitarism is given.