quantal release
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Author(s):  
E. O. Tarasova ◽  
N. A. Khotkina ◽  
P. O. Bogacheva ◽  
K. A. Chernyshev ◽  
A. E. Gaydukov ◽  
...  

2021 ◽  
Author(s):  
Xiao-Ke Yang ◽  
Fu-Li Zhang ◽  
Wen-Tao Wu ◽  
Yun Tang ◽  
Jing Yan ◽  
...  

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yolanda Gimenez-Molina ◽  
Virginia García-Martínez ◽  
José Villanueva ◽  
Bazbek Davletov ◽  
Luis M. Gutiérrez

AbstractFTY-720 (Fingolimod) was one of the first compounds authorized for the treatment of multiple sclerosis. Among its other activities, this sphingosine analogue enhances exocytosis in neuroendocrine chromaffin cells, altering the quantal release of catecholamines. Surprisingly, the size of chromaffin granules is reduced within few minutes of treatment, a process that is paralleled by the homotypic fusion of granules and their heterotypic fusion with mitochondria, as witnessed by dynamic confocal and TIRF microscopy. Electron microscopy studies support these observations, revealing the fusion of several vesicles with individual mitochondria to form large, round mixed organelles. This cross-fusion is SNARE-dependent, being partially prevented by the expression of an inactive form of SNAP-25. Fused mitochondria exhibit an altered redox potential, which dramatically enhances cell death. Therefore, the cross-fusion of intracellular organelles appears to be a new mechanism to be borne in mind when considering the effect of FTY-720 on the survival of neuroendocrine cells.


2019 ◽  
Vol 253 ◽  
pp. 106241 ◽  
Author(s):  
Giulia Tomagra ◽  
Claudio Franchino ◽  
Alberto Pasquarelli ◽  
Emilio Carbone ◽  
Paolo Olivero ◽  
...  

2019 ◽  
Vol 13 ◽  
Author(s):  
Giulia Tomagra ◽  
Federico Picollo ◽  
Alfio Battiato ◽  
Barbara Picconi ◽  
Silvia De Marchis ◽  
...  

2018 ◽  
Vol 8 (4) ◽  
pp. 984-987
Author(s):  
Dmitry V. Samigullin ◽  
Nikita V. Zhilyakov ◽  
Eduard F. Khaziev ◽  
Ellya A. Bukharaeva ◽  
Eugeny E. Nikolsky

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