INTRAMOLECULARLY HYPERCOORDINATED ORGANOLEAD COMPOUNDS: (o-MeOC6H4-CH2)PbPh2R, R = Ph, Cl, WITH Pb–O SECONDARY BONDING

The tetrahedral geometry of organolead(IV) compounds can be readily transformed by using an organic ligand containing a dangling-arm oxygen functionality. The acidity of the Pb center results in so-called secondary bonding between O and Pb thereby pushing the geometry at Pb toward a trigonal bipyramidal (tbp) structure. Replacing a phenyl group by a chlorine atom dramatically enhances this phenomenon. Thus for (o-methoxybenzyl) triphenyllead (4), and (o-methoxybenzyl)diphenyllead chloride (5), the Pb–O internuclear distances are 3.362(4) and 2.845(3) Å, respectively; 83% (4) and 70% (5) of the sum of the van der Waals Pb and O radii. Within the group 14 element congeners the structural analysis of the (o-methoxybenzyl)triphenylE compounds, E = Si, Ge, Sn, and now Pb, demonstrates the relative acidities of E are Si < Ge < Sn < Pb.

Direct introduction of nitrogen and oxygen functionality with spatial control using copper catalysis

Synthetic chemists have spent considerable effort optimizing the synthesis of nitrogen and oxygen containing compounds through a number of methods; however, direct introduction of N- and O-functionality remains challenging.

Synthesis of 2,3-allenylamides utilizing [1,2]-phospha-Brook rearrangement and their application to gold-catalyzed cycloisomerization providing 2-aminofuran derivatives

An efficient synthetic method for 2,3-allenylamides having an oxygen functionality at the 2-position was newly developed by utilizing the [1,2]-phospha-Brook rearrangement under Brønsted base catalysis.