This chapter focuses on epidemics in New England before 1780. Barker describes his move from Barnstable, Massachusetts, to Gorham, Maine, with information about the town, dietary habits, and physicians in Cumberland County. He cites the diary of the Reverend Thomas Smith, who began his ministerial duties at the First Parish Church in Falmouth (Portland) in 1727 and cared for his parishioner’s medical as well as spiritual needs, keeping a diary of diseases and epidemics beginning in 1735. Diary entries describe the severe epidemic of throat distemper, also known as cynache maligna or putrid sore throat, in 1735, with recurrences in 1754, 1784, and 1801–1802. Various treatments including the use of blistering are discussed, as well as the use of mercury (calomel) in a long excerpt from John Warren’s article, “View of mercurial practice” published in the New England Journal of Medicine in 1813.