Assessing the Impact of the Foreign Economic Complex on the Economic Immunity of a Regional System

Aim. The presented study aims to confirm the hypothesis that the type of economic immunity of a territory is determined by a specific concentration of activity of economic entities, with the foreign economic complex of the region playing an important role.Tasks. The authors expand the notion of economic immunity of a regional system and identify its influencing factors; develop a methodological approach to assessing the impact of the foreign economic complex on regional immunity; test the assessment methodology and formulate directions for improving the operation of the foreign economic complex in the context of transformations in the economic immunity of regional systems.Methods. This study uses general scientific methods of cognition to examine the concept of regional economic immunity and substantiate the structure of the region’s foreign economic complex from the perspective of its interaction with certain economic processes occurring in the regional system. Regression models serve as the basis of the methodological approach to assessing the degree of influence of the foreign economic complex on the formation of regional economic immunity.Results. The proposed original methodology is tested by analyzing data for 2012-2018 on the development of 59 constituent entities of the Russian Federation that are industrial regions and have foreign economic relations. The performance of the regional foreign economic complex and its correlation with the region’s development indicators are determined. Three main types of economic immunity of regional systems (extractive, inclusive, and mixed) are identified, forming under the influence of the foreign economic complex, and the examined regions are grouped by types of economic immunity.Conclusions. Based on the determined characteristic differences in the formation of the types of regional economic immunity, and with the inclusive type being the most effective option for diversifying exports, creating new jobs, and improving the population’s quality of life as a whole, the necessity of incentives in the transition of regional economies towards the formation of this type of immunity is substantiated. This makes it possible to identify three main scenarios of transition towards the inclusive type of regional economic immunity: the first scenario involves the transformation of the extractive type of immunity into mixed, allowing for a smoother transition towards the desired type and for the establishment or reformation of existing institutions in the territory; the second scenario involves the transformation of the mixed type of immunity into inclusive by diversifying the economy and exports; the third scenario is premised on enhancing the inclusiveness of immunity by expanding exports of high-tech products.

Systemic inflammation suppresses lymphoid tissue remodeling and B cell immunity during concomitant local infection

Concurrent infection with multiple pathogens occurs frequently in individuals and can result in exacerbated infections and altered immunity. However, the impact of such coinfections on immune responses remains poorly understood. Here we reveal that systemic infection results in an inflammation-induced suppression of local immunity. During localized infection or vaccination in barrier tissues including the skin or respiratory tract, concurrent systemic infection induced a type I interferon-dependent lymphopenia that impairs lymphocyte recruitment to the draining lymph node (dLN). This leads to suppressed lymphoid stromal cell expansion and dLN remodeling and impaired induction of B cell responses and antibody production. Our data suggest that contemporaneous systemic inflammation constrains the induction of regional immunity.

The Crosstalk between Fat Homeostasis and Liver Regional Immunity in NAFLD

The liver is well known as the center of glucose and lipid metabolism in the human body. It also functions as an immune organ. Previous studies have suggested that liver nonparenchymal cells are crucial in the progression of NAFLD. In recent years, NAFLD’s threat to human health has been becoming a global issue. And by far, there is no effective treatment for NAFLD. Liver nonparenchymal cells are stimulated by lipid antigens, adipokines, or other factors, and secreted immune factors can alter the expression of key proteins such as SREBP-1c, ChREBP, and PPARγ to regulate lipid metabolism, thus affecting the pathological process of NAFLD. Interestingly, some ncRNAs (including miRNAs and lncRNAs) participate in the pathological process of NAFLD by changing body fat homeostasis. And even some ncRNAs could regulate the activity of HSCs, thereby affecting the progression of inflammation and fibrosis in the course of NAFLD. In conclusion, immunotherapy could be an effective way to treat NAFLD.