synaptopodin 2
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2021 ◽  
pp. 112865
Author(s):  
Keerthika Lohanadan ◽  
Sibylle Molt ◽  
Franziska Dierck ◽  
Peter F.M. van der Ven ◽  
Norbert Frey ◽  
...  

Heliyon ◽  
2021 ◽  
pp. e07347
Author(s):  
Md. Shahadat Hossain ◽  
Mahafujul Islam Quadery Tonmoy ◽  
Md. Nur Islam ◽  
Md. Sajedul Islam ◽  
Ibrahim Khalil Afif ◽  
...  

Genes ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 166
Author(s):  
Ariene Fernanda Grando Rodrigues ◽  
Adriana Mércia Guaratini Ibelli ◽  
Jane de Oliveira Peixoto ◽  
Maurício Egídio Cantão ◽  
Haniel Cedraz de Oliveira ◽  
...  

Hernia is one of the most common defects in pigs. The most prevalent are the scrotal (SH), inguinal (IH) and umbilical (UH) hernias. We compared the inguinal ring transcriptome of normal and SH-affected pigs with the umbilical ring transcriptome of normal and UH-affected pigs to discover genes and pathways involved with the development of both types of hernia. A total of 13,307 transcripts was expressed in the inguinal and 13,302 in the umbilical ring tissues with 94.91% of them present in both tissues. From those, 35 genes were differentially expressed in both groups, participating in 108 biological processes. A total of 67 polymorphisms was identified in the inguinal ring and 76 in the umbilical ring tissue, of which 11 and 14 were novel, respectively. A single nucleotide polymorphism (SNP) with deleterious function was identified in the integrin α M (ITGAM) gene. The microtubule associated protein 1 light chain 3 γ (MAP1LC3C), vitrin (VIT), aggrecan (ACAN), alkaline ceramidase 2 (ACER2), potassium calcium-activated channel subfamily M α 1 (KCNMA1) and synaptopodin 2 (SYNPO2) genes are highlighted as candidates to trigger both types of hernia. We generated the first comparative study of the pig umbilical and inguinal ring transcriptomes, contributing to the understanding of the genetic mechanism involved with these two types of hernia in pigs and probably in other mammals.


2020 ◽  
Vol 250 (1) ◽  
pp. 99-110
Author(s):  
Emily R. Czajkowski ◽  
Marilyn Cisneros ◽  
Bianca S. Garcia ◽  
Jim Shen ◽  
Richard M. Cripps

2020 ◽  
Vol 482 ◽  
pp. 8-18
Author(s):  
Jie Gao ◽  
Hua-Peng Zhang ◽  
Yao-Hui Sun ◽  
Wen-Zhi Guo ◽  
Jie Li ◽  
...  

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 2997 ◽  
Author(s):  
Liping Gan ◽  
Vladimir Camarena ◽  
Sushmita Mustafi ◽  
Gaofeng Wang

Vitamin C supplementation has been shown to decrease triple-negative breast cancer (TNBC) metastasis. However, the molecular mechanism whereby vitamin C inhibits metastasis remains elusive. It has been postulated that vitamin C reduces the levels of HIF-1α, the master regulator of metastasis, by promoting its hydroxylation and degradation. Here, we show that vitamin C at 100 µM, a concentration achievable in the plasma in vivo by oral administration, blocks TNBC cell migration and invasion in vitro. The protein level of HIF-1α remains largely unchanged in cultured TNBC cells and xenografts, partially due to its upregulated transcription by vitamin C, suggesting that HIF-1α unlikely mediates the action of vitamin C on metastasis. Vitamin C treatment upregulates the expression of synaptopodin 2 and downregulates the expression of the transcription coactivator YAP1, both genes in the Hippo pathway. The changes in SYNPO2 and YAP1 expression were subsequently validated at mRNA and protein levels in cultured TNBC cells and xenografts. Further experiments showed that vitamin C treatment inhibits F-actin assembly and lamellipodia formation, which correlates with the changes in SYNPO2 and YAP1 expression. Overall, these results suggest that vitamin C inhibits TNBC metastasis by affecting the expression of SYNPO2 and YAP1. Vitamin C may thus have a potential role in the prevention and treatment of TNBC metastasis.


2018 ◽  
Vol Volume 10 ◽  
pp. 1575-1583 ◽  
Author(s):  
Erjie Xia ◽  
Xiaofen Zhou ◽  
Adheesh Bhandari ◽  
Xiaohua Zhang ◽  
Ouchen Wang

2017 ◽  
Vol 244 (1) ◽  
pp. 71-83 ◽  
Author(s):  
Junling Liu ◽  
Liping Ye ◽  
Qingyuan Li ◽  
Xianqiu Wu ◽  
Bin Wang ◽  
...  

2015 ◽  
Vol 35 (6) ◽  
pp. 1489-1497 ◽  
Author(s):  
Karolina M. Turczyńska ◽  
Karl Swärd ◽  
Tran Thi Hien ◽  
Johan Wohlfahrt ◽  
Ingrid Yao Mattisson ◽  
...  

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