Exploration of PPP Investment and Financing Model for Infrastructure: A Case Study of the Beijing-Tianjin-Hebei Region

With the overall weakening of the macroeconomic situation, the investment growth in Beijing-Tianjin-Hebei continued to slow down. This article focuses on the reform and innovation of investment and financing models in the vertical and horizontal collaborative construction of Beijing-Tianjin-Hebei infrastructure. Under the framework of the PPP model, this article discusses how to design a market-oriented platform of infrastructure investment and financing model, introduce and use private capital, build remote capital access and exit mechanism, measure the government’s financial capacity and financial risks in the PPP model, set up PPP institutions, and improve relevant laws and regulations to make the infrastructure construction and operation more efficient, thus promoting the coordinated development of infrastructure construction in the Beijing-Tianjin-Hebei region.

Listening to vaccine refusers

In bioethics vaccine refusal is often discussed as an instance of free riding on the herd immunity of an infectious disease. However, the social science of vaccine refusal suggests that the reasoning behind refusal to vaccinate more often stems from previous negative experiences in healthcare practice as well as deeply felt distrust of healthcare institutions. Moreover, vaccine refusal often acts like an exit mechanism. Whilst free riding is often met with sanctions, exit, according to Albert Hirschman’s theory of exit and voice is most efficiently met by addressing concerns and increasing the quality and number of feedback channels. If the legitimate grievances responsible for vaccine refusal are not heard or addressed by healthcare policy, further polarization of attitudes to vaccines is likely to ensue. Thus, there is a need in the bioethics of vaccine refusal to understand the diverse ethical questions of this inflammable issue in addition to those of individual responsibility to vaccinate.

Research on the Survival Analysis of Chinese ST Enterprises

For a long time, some companies have basically no revenue, but have not delisted from the market with poor performance, reflecting the embarrassment of the system. One of the reasons for the difficulty of enterprise delisting is the existence of ST companies in the market, which results in the scarcity of shell resources of listed companies. How to optimize the market exit mechanism has become an urgent problem to be solved. This paper selects Chinese listed companies that were processed by ST from 1998 to 2020 as the research object, and uses survival analysis to study the survival problems of ST companies, that is, the time rule of ST companies' delisting and delisting. The results show that the probability of capping incidents of listed companies after the implementation of special treatment increases first and then decreases, reaching a peak in the second year after the implementation of ST, and a substantial decline in the third year, and it can be achieved in the sixth year and beyond. Few ST companies have decapitated; the probability of delisting events of listed companies after the implementation of special treatment also increases first and then decreases, reaching a peak in the third year after the implementation of ST. In the fifth year and beyond, few ST companies have retired. city.

Neuropilin-1 Assists SARS-CoV-2 Infection by Stimulating the Separation of Spike Protein Domains S1 and S2

The cell surface receptor Neuropilin-1 (Nrp1) was recently identified as a host factor for SARS-CoV-2 entry. As the Spike protein of SARS-Cov-2 is cleaved into the S1 and the S2 domain by furin protease, Nrp1 binds to the newly created C-terminal RRAR amino acid sequence of the S1 domain. In this study, we model the association of a Nrp1 (a2-b1-b2) protein with the Spike protein computationally and analyze the topological constraints in the SARS-CoV-2 Spike protein for binding with Nrp1 and ACE2. Importantly, we study the exit mechanism of S2 from the S1 domain with the assistance of ACE2 as well as Nrp1 by molecular dynamics pulling simulations. In the presence of Nrp1, by binding the S1 more strongly to the host membrane, there is a high probability of S2 being pulled out, rather than S1 being stretched. Thus, Nrp1 binding could stimulate the exit of S2 from the S1 domain, which will likely increase virus infectivity as the liberated S2 domain mediates the fusion of virus and host membranes. Understanding of such a Nrp1-assisted viral infection opens the gate for the generation of protein-protein inhibitors, such as antibodies, which could attenuate the infection mechanism and protect certain cells in a future combination therapy.

THE ESTABLISHMENT OF THE LOCAL GOVERNMENT INDUSTRIAL INVESTMENT FUND IN CHINA: AN EMPIRICAL STUDY

The Chinese market is an ever booming market whereby access to information is becoming more effortless and more manageable. This study aims to analyse the establishment of a local government industrial investment fund in China. A quantitative analysis constitutes this study. The latest literature and previous research on the regulatory system, the business exit mechanism, practitioners, lack of risk prevention and the portfolio of single funds are independent variables based on a model structure. The policy is an intermediate variable, and a non-independent variable is the sustainable promotion of the production of industrial investment funds. The results indicate that there is a partnership between the Local Government Industrial Investment Fund in Henan, China and the Local Government Industrial Investment Fund Growth Fund in Henan, China. This research has also shown that the higher the perceived structure of the supervisory system and the business exit process of the industrial investment fund for the local government in Henan, China. This will motivate policy to think or have a good impression on the industrial investment funds for the Henan government. The higher the perceived supervision system structure and market exit mechanism, the better the policy. JEL: D25; E22; G18; L50 <p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/0729/a.php" alt="Hit counter" /></p>

DEVELOPMENT OF THE INDUSTRIAL INVESTMENT FUND FOR THE LOCAL GOVERNMENT IN CHINA

The purpose of this study is to examine the development of the industrial investment fund for the local government in China. This study constitutes a quantitative study. Based on a model framework, the existing literature and previous studies on the regulatory mechanism, market exit mechanism, professionals, lack of risk prevention, single fund portfolio are independent variables. The policy is an intermediate variable, and sustainable promotion of industrial investment fund development is a non-independent variable. Findings show that there is a relationship between Industrial investment fund for the local government in Henan, China and Development of the industrial investment fund for the local Government in Henan, China. This study has also revealed that higher the perceived supervision system structure and market exit mechanism of industrial investment fund for the local government in Henan, China, policy Industrial investment fund for the local government in Henan, China becomes higher. Industrial investment fund for the local government in Henan, China providers and industrial investment fund for the local government in Henan, China business developers will have to realize the importance of knowing and understanding policy perception on industrial investment fund for the local government in Henan, China as is vital in inducing policy. <p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/edu_01/07780/a.php" alt="Hit counter" /></p>

How FDI attracted? A Configurational Analysis for Regional Competitiveness in Mechanism of FDI Entry and Exit: Evidence from China

The economic benefits and spillover effects from FDI could lead accelerating the innovation of local economy and technological concept, which make it welcome in underdeveloped countries' authorities. This paper focuses on the entry and exit mechanism of FDI in 31 provinces of China from 2001 to 2016. The optimized diamond model associated with multi-theoretical cooperation is adopted to set up the regional competitiveness configuration for attracting FDI. It revealed that FDI attempts to enter regions with certain economic basis and favorable government conditions; but if the market fluctuates, even if there are favorable policy conditions, FDI will restructure because of their profit-seeking. Based on the conclusions, local governments can use the minimum resources to attract FDI in appropriate circumstances, and can optimize policies in time when it is not suitable for the entry and maintenance of FDI, so as to focus on develop local markets.

The Influence of Human Capital on Re-entry Intention of Indian Micro and Small Enterprise Owners: An Empirical Investigation

Entrepreneurial exit is an important phase of the entrepreneurial process that has a significant impact on enterprises and the economy. Extant research in developed countries has shown that personal and business motives of entrepreneurs trigger exit intentions, which, in turn, affect their choice of exit strategy. Though all-India census indicates that most of the closed enterprises are micro and small enterprises (MSE), the factors influencing the exit decision of the Indian MSE owners still remain largely unexplored due to their unorganised nature. Since the majority of Indian MSEs are owned by individuals, and human capital represents the assets of each individual, this article aims to understand the influence of entrepreneurs’ human capital on exit intention for re-entry using the theory of planned behaviour. This study employs a questionnaire-based survey approach and uses a sample size of 150 MSE owners of working enterprises in industrial estates of Mangalore and Udupi districts for hypotheses testing. Empirical analysis is performed using SPSS software, and the results indicate that entrepreneurs with good health and inherited experience have exit intentions and subsequent entrepreneurial re-entry. This knowledge may be useful for stakeholders to understand serial entrepreneurship with a proper exit mechanism.

A FOXO-dependent replication checkpoint restricts proliferation of damaged cells

DNA replication is challenged by numerous exogenous and endogenous factors that can interfere with the progression of replication forks. Stalling or slowing of the replication fork as a result of replication stress leads to formation of aberrant single-stranded DNA (ssDNA) stretches and potentially DNA double-stranded-breaks (DSBs). Accumulation of ssDNA activates the ATR-dependent DNA replication stress checkpoint response that slows progression from S/G2- to M-phase to protect genomic integrity (1). However, whether mild replication stress restricts proliferation remains controversial (2–6). Here we identify a novel cell cycle exit mechanism, that prevents S/G2 phase arrested cells from undergoing mitosis after exposure to mild replication stress through premature activation of the CDH1 bound Anaphase Promoting Complex / Cyclosome (APC/CCDH1). We find that replication stress causes a gradual decrease of the levels of the APC/CCDH1 inhibitor EMI1/FBXO5 through Forkhead Box O (FOXOs) mediated repression of its transcriptional regulator E2F1. By doing so, FOXOs limit the time during which the replication stress checkpoint is reversible, and thereby play an important role in maintaining genomic stability.