Unsymmetrical Growth Synthesis of Nontraditional Dendrimers

Developing highly complex molecules is of great significance in science and technology. Here we present an unprecedented type of dendrimer assembled from linear ABB-type monomer. The construction of this nontraditional ramified architecture was facilely achieved through one simple convergent strategy established on the iridium-catalyzed cycloaddition of organic azides with internal 1-thioalkynes (IrAAC). By virtue of the unsymmetrically growing fashion in this process, diverse functional groups could be conveniently distributed on both of its exterior and interior layers. Syntheses of two dendrons from the cooperation of one linear alkyne motif with different azides were presented to demonstrate the efficiency and fidelity of this protocol. Post-modifications on their core or periphery were further conducted, resulting in diverse newly functionalized dendrimers with up to ~16.0 kDa molecular weight. The identity and purity of these unsymmetrical dendritic macromolecules were well confirmed by 1H NMR, MS and SEC analysis.

Exotic Nuclear Spin Behavior in Dendritic Macromolecules

Dendrimers are a class of branched, highly symmetric macromolecules that have been shown to be useful for a vast number of different applications. Potential uses as fluorescence sensors, in catalysis...

Micelle carriers based on dendritic macromolecules containing bis-MPA and glycine for antimalarial drug delivery

Biocompatible dendrimer-based carriers suitable for antimalarial drug transport: cell targeting and in vitro and in vivo analysis of Plasmodium growth inhibition.

Anisotropic convergence of dendritic macromolecules facilitated by a heteroleptic metal–organic polyhedron scaffold

Anisotropic dendrimers with bipolar shapes were systematically obtained using a heteroleptic metal–organic polyhedron (MOP) as a robust core scaffold.