Obstetric outcomes really worse with the induction of labor

Objective: to describe the obstetric outcomes in patients with an active induction of labor (IOL). Methods: 1037 deliveries were included. In case of IOL, women with unfavorable cervix (Bishop≤6) start with 2 tablets of 25mcg vaginal misoprostol followed by a new tablet every 4 hours up to a maximum of 4 doses. In case of any contraindication for misoprostol a 10mg tablet of dinoprostone was inserted into the vagina. In any case, a cardiotocographic record during 30 minutes was performed previous to each dose. When Bishop was >6, artificial rupture of membranes and oxytocin stimulation was performed. Results: Of 351 spontaneous deliveries, 57 (16.24%) were urgent cesarean section, 211 (60.11%) were eutocic, 58 (7.12%) ended by forceps and 58 (16.52%) by vacuum. Among the IOL (556), 127 (22.84%) completed the delivery by urgent cesarean section, 291(52.33%) were eutocic, 55 (9.89%) ended by forceps and 81 (14.56%) by vacuum Conclusion: the active attitude during the IOL favors results similar to those when the delivery is spontaneous.

New Poly Vinyl Chloride Ion Selective Electrode for Potentiometric Analysis of Propranolol in its Pharmaceutical Formulations and Human Fluids

New, simple, sensitive and rapid method for the determination of propranolol in the pharmaceutical preparations and human fluids. The Buildup and electrochemical response characteristics of a poly vinyl chloride (PVC) selective membrane electrode for the determination of propranolol (POP) are described in this research. The proposed electrodes was composed of propranolol-bromophenol blue as ion-exchanger and Di-butyl phthalate (DBPH) (electrode A), tris (2-ethylhexyl) phosphate (TEHP) (electrode B), and ortho-nitrophenyloctylether (ONPOE) (electrode C), as plasticizers. The slope was 50.94, 57.77, and 49.75 mV/decade for electrode A, B and C. the linear range was 5 ×10-5 – 1×10-2, 1×10-4 – 1×10-2, and 5×10-5 – 1×10-2 M, a detection limit of 4.2×10-5, 8.9×10-5, and 4.8×10-5 M, lifetime of 21, 42, and 1-day, respectively. Electrode B gives the best results, so the application of pharmaceutical and human fluids was based upon this electrode, the recovery percentage was 103, 101, 102.5, and 104 for POP tablet 10mg, tablet 40mg, urine and plasma by standard addition method, respectively.

A STUDY ON IV LABETALOL VERSUS ORAL NIFEDIPINE IN ACUTE CONTROL OF SEVERE HYPERTENSION IN PREGNANCY

Objective: To compare the efficacy of IV Labetalol with oral Nifedipine in the treatment of severe hypertension in pregnancy with blood pressure >160/110mm Hg. Methods:A parallel double blinded randomized control trial between Jan 2019 and May 2019 in 100 antenatal women of gestational age>28 weeks, admitted with blood pressure >160/110 mm Hg conducted in labour ward tertiary hospital. Antenatal women were randomized to receive oral Nifedipine 10mg tablet orally up to 5 doses and IV Labetalol was initiated at 20mg and in escalating doses of 20mg, 40mg.80mg, and 80mg up to 220mg. The number of doses and meantime taken to achieve target blood pressure <140/90 mm Hg was noted. Results:hundred antenatal women were randomized to 50 in each group.In the Labetalol group 5 patients required oral Nifedipine to achieve target blood pressure but none in the Nifedipine group. The numbers of doses required and meantime taken to achieve target bloodpressure in nefidipine group were less compared to that of Labetalol group. Conclusion: IV Labetalol and oral Nifedipine were equally effectively to achieve target blood pressure.Incomparsion, oral Nifedipine achieved target blood pressure more quickly than Labetalo

Cost variation analysis of various brands of anti-epileptic drugs currently available in Indian pharmaceutical market

Background: Epilepsy is a common neurological disorder affecting about 10 million persons in India. The compliance to a particular antiepileptic drug is highly dependent on the cost of the drug which directly translates into success or failure of therapy. Hence there is a need for all clinicians to keep themselves updated with the latest prices and price variation of the commonly prescribed drugs. This study aims to analyze cost variation of various brands of anti-epileptic drugs currently available in Indian pharmaceutical market.Methods: Current Index of Medical Specialities July-October 2016 edition was referred to know the maximum and minimum price in INR of various brands of anti- epileptic drugs in India. Further analysis was done by using Percentage Cost Variation.Results: There is wide variation in the prices of different brands of same antiepileptic agents in Indian market. The highest % cost variation was found for diazepam 5mg tablet (374.42), followed by lorazepam 2mg tablet (213.63), carbamazepine 100mg syrup/5ml-100ml (172.58), levetiracetam 1000mg FC-tablet (168.57), lamotrigine 25mg DIS- tablet (150), clobazam 10mg tablet (147.37), clonazepam 0.5mg tablet (145.90), oxcarbazepine 150mg tablet (89.46), gabapentin 300mg capsule (71.67), valproic acid 200mg FC-tablet (58.62), divalproex sodium 500mg ER-tablet (47.82), topiramate 50mg tablet (41.66) and lowest % cost variation was of phenytoin sodium 300mg tablet (0.23).Conclusions: The average percentage price variation of different brands of same oral anti-epileptic drug in Indian market is very wide. To counter act such cost variation, physicians should be encouraged to prescribe a medication brand with low cost. This in turn reduces the unnecessary economic burden to the patients.