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2018 ◽  
Vol 15 (4) ◽  
pp. 1393-1406
Author(s):  
Adrian Lara ◽  
Shreyasee Mukherjee ◽  
Byrav Ramamurthy ◽  
Dipankar Raychaudhuri ◽  
K. K. Ramakrishnan

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Dagmar Berankova ◽  
Eva Janousova ◽  
Martina Mrackova ◽  
Ilona Eliasova ◽  
Milena Kostalova ◽  
...  

Objective. The main aim of this study was to verify the sensitivity and specificity of Addenbrooke’s Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson’s disease (PD) with normal cognition (PD-NC) and PD with mild cognitive impairment (PD-MCI) and between PD-MCI and PD with dementia (PD-D). We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD.Methods. We examined three age-matched groups of PD patients diagnosed according to the Movement Disorder Society Task Force criteria: PD-NC, PD-MCI, and PD-D. ROC analysis was used to establish specific cut-off scores of ACE-R and its domains. Correlation analyses were performed between ACE-R and its subtests with relevant neuropsychological tests.Results. Statistically significant differences between groups were demonstrated in global ACE-R scores and subscores, except in the language domain. ACE-R cut-off score of 88.5 points discriminated best between PD-MCI and PD-NC (sensitivity 0.68, specificity 0.91); ACE-R of 82.5 points distinguished best between PD-MCI and PD-D (sensitivity 0.70, specificity 0.73). The verbal fluency domain of ACE-R demonstrated the best discrimination between PD-NC and PD-MCI (cut-off score 11.5; sensitivity 0.70, specificity 0.73) while the orientation/attention subscore was best between PD-MCI and PD-D (cut-off score 15.5; sensitivity 0.90, specificity 0.97). ACE-R scores except for ACE-R language correlated with specific cognitive tests of interest.


2007 ◽  
Vol 42 (1) ◽  
pp. 67-104 ◽  
Author(s):  
D. Li ◽  
X. L. Sun ◽  
J. Wang ◽  
K. I. M. McKinnon

The diffraction of a pressure discontinuity by a wedge is attacked by posing the pressure as a homogeneous function of r/ct , where r , c and t are the distance from the edge, acoustic velocity and time. The scattered wave is then determined by reducing the original wave equation to Laplace’s equation with the aid of a Tschplygin transformation and applying Poisson’s formula to the sectoral domain cut out of the circle r≤ct by the wedge. The result appears in simpler form than that previously obtained by Sommerfeld.


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