314. Six-Month Post-Acute Sequelae of COVID-19: High Self-Reported Morbidity among Women and Younger Adults

Background Long term sequelae across multiple medical domains, including the respiratory, psychiatric, and neurocognitive have been reported after COVID-19. Studies evaluating the impact of this symptom burden, however, are lacking. We aimed to describe the self-reported occurrence of symptoms and their effect on patient functioning six months after their acute hospitalization for COVID-19. Methods From a historical cohort study of patients hospitalized for COVID-19 between March 8, and June 14, 2020, we identified patients discharged home. The purpose of the study was explained, and they were asked to consent to a telephone questionnaire. We used a modified version of a previously validated general symptom questionnaire (GSQ-30) to assess multi-system symptom burden. The Patient Health Questionnaire-2 (PHQ-2) was used to screen for major depression. Results Of the original 565 patients, 258 patients were discharged home (45%). Of these, 57 (22%) patients were able to be contacted and agreed to participate in the survey. The mean (SD) age of the respondents was 55.1 (14.8) years, and 37 (64.9%) were female. The most common symptoms at follow-up were fatigue (60.0%), dyspnea (57.1%), feeling irritable, sad or decreased pleasure (56.4%), and memory difficulty (56.4%). Females had a significantly higher GSQ score (0.02) than males. Patients ages < 60 years tended to experience similar, if not greater, impaired functioning (p=0.07) compared with those ages ≥ 60 years (Table 1). Females were more likely to be irritable or sad (p=0.007), not feel rested on awakening (p=0.04), have shooting, stabbing and burning pain (p=0.02), have discomfort with normal light and sound (p=0.04), and have memory difficulty (p=0.04) than males (Table 2). Table 1. Self-Reported Post-Acute Sequelae of COVID syndrome in adults younger than 60 versus adults at or older than 60 Years. SD: Standard deviation, ICU: Intensive care unit, ED: Emergency department, GSQ - General symptom questionnaire, PHQ-2: Patient Health Questionnaire-2 Table 2. Self-Reported Post-acute Sequelae of COVID syndrome in female versus male adults. SD: Standard deviation, ED: Emergency department, GSQ - General symptom questionnaire, PHQ-2: Patient Health Questionnaire-2 Conclusion Our study describes the clinical burden of post-acute sequelae of COVID-19 (PASC) in four core domains: fatigue, neurologic, neuro-psychiatric and viral-like symptoms. Over 45% of patients ages < 60 years suffered impaired functioning, compared with 21.1% of patient’s ages 60 years and above. Females had significantly higher GSQ scores than men which strongly corelates with the functional impairment among the females. Larger studies are needed to further validate our findings. Disclosures All Authors: No reported disclosures

Lacking Communication Would Increase General Symptom Index Scores of Medical Team Members During COVID-19 Pandemic in China: A Retrospective Cohort Study

There are few studies on the psychological status of medical staff during the COVID-19 outbreak. Our study addresses whether lack of communication affects the psychological status of medical team members supporting Wuhan during the COVID-19 pandemic in China. We used general symptom index (GSI) scores of the Symptom Checklist-90 (SCL-90) to evaluate participants’ psychological status. We adopted a stratified sampling method and selected the fourth team, with a total of 137 members, as participants. In total 76.6% and 69.7% of female and male participants, respectively, had bachelor’s degrees; 41.6% and 21.2% of female and male participants, respectively, were unmarried. Regarding communication, 14.29% and 6.06% of female and male participants, respectively, reported a lack of communication with the team (LCWT). Additionally, 13.0% and 6.1% of female and male participants, respectively, experienced fear of being infected (FoBI). LCWT and FoBI were positively correlated with GSI score (estimated change = 0.2, 95% CI [0.1-0.3]). When adjusted for gender, age, and FoBI, LCWT was positively correlated with GSI score ( P < .05). Increasing communication among medical team members can reduce GSI scores.

Correlation analysis of risk factors and GSI score of a medical team assisting Wuhan city during the epidemic of COVID-19 in China -A cohort study

ImportanceThere are few studies on the psychological status of medical staff during the COVID-19 outbreak. This study is the first in the world about the psychological status of the medical team during the COVID-19 outbreak.ObjectiveTo study the correlation between risk factors and general symptom index (GSI) score of medical team members who support Wuhan against COVID-19.DesignCohort study.SettingPopulation-based.ParticipantsAnhui Province sent a total of eight medical teams, including 1382 members, to support Hubei Province. We adopted a stratified sampling method and selected the fourth team sent by Anhui Provincial Hospital, with a total of 137 members as our subjects.ExposuresFour main exposures were collected, including basic information, preparations before going to Wuhan, life issues and working issues after going to Wuhan.Main Outcomes and MeasuresThe GSI score of SCL-90 scale was used to reflect the frequency and intensity of psychological symptoms. We made the hypothesis of this study before data collection.Results110(80.29%) members completed the questionnaire, of which, 77(70.00%) female and 33(30.00%) male. When adjusted age, gender and covariates, DC, LCWT had a positive correlations with GSI score(β was10.17, 95%CI was 3.30 to 17.04 for DC, P=0.00<0.05; β was 11.55, 95%CI was 0.40 to 22.71 for LCWT, P =0.04<0.05;respectively), RBT had a negative positive correlation with GSI score (β was -28.09, 95%CI was -45.79 to -10.40, P=0.00<0.05), AoBI did not had a correlation with GSI score (β was 11.55, 95%CI was 0.40 to 22.71, P=0.16>0.05). When adjusted covariates, DC had a positive and RBT had a negative correlation with GSI score of female (β was 13.20, 95%CI was 4.55 to 21.85, P=0.00<0.05; β was -57.85, 95%CI was -94.52 to -21.18, P=0.00<0.05; respectively), but for male was not (P=0.59>0.05, P=0.08>0.05, respectively), LCWT and AoBI didn’t had correlation with GSI score between genders (P>0.05).Conclusions and RelevanceImproving DC, RBT and decreasing LCWT can reduce the GSI score. AoBI didn’t affect the psychological status; male members have a more stable mood than female. Whether other countries medical team has the same result still needs further research.Key PointsQuestionWhat is the correlation between risk factors and general symptom index (GSI) score of medical team members who support Wuhan against COVID-19?FindingsDietary conditions (DC) had a positive and relationship between team (RBT) had a negative correlation with GSI score of female, but for male was not (P=0.59>0.05, P=0.08>0.05, respectively), lacking communication with teams (LCWT) and afraid of being infected (AoBI) didn’t had correlation with GSI score between genders, a significant difference.MeaningImproving DC, RBT and decreasing LCWT between team members can reduce the GSI score. Whether they are AoBI, didn’t affect the psychological status, male members have a more stable mood than female.

REPRESENTASIANAK KALIMAT DALAM TEKS BERITA POLITIK PILPRES PADA SURAT KABAR KOMPAS EDISI OKTOBER 2018 s.d MARET 2019

The journalist task has shifted from the news transmitter to the news formator and instructor. It shows that in writing news, journalist adds various comment, opinion and review that are difficult to distinguish from the news itself. A journalist should have a variety of rights and obligations, namely to deliver news in accordance with fact without mixing opinion.This study aims to reveal and expose the hidden aspects behind an apparent reality.This research methodology uses a qualitative descriptive approach. A qualitative approach is a research procedure that produces descriptive data in the form of the phenomenon description contained in the data. The data collected is in the form of newspaper document.The result of study shows that there is finding regarding representation, namely association and metaphor. The association was appeared in the news of compass newspaper by journalist to bring assumption in the mind of public in interpreting a certain reality regarding the debate between Jokowi and Prabowo. Journalist brings up how Prabowo take an action against Jokowi which is marked by transitive sentence namely subject + verb + object. Bring up a general symptom or phenomenon that occurs in the society regarding the legislative candidate photo displayed along the road. The form of participant as victim or object can be known from the construction of passive sentence, or victim caused by other.

Symptoms and anxiety predict declining health-related quality of life in multiple myeloma: A prospective, multi-centre longitudinal study

Background: Patients with multiple myeloma, an incurable haematological cancer, often receive palliative care only late in their trajectory. Criteria for early referral are lacking. Aim: To identify which patients might benefit from early integration, by identifying trajectories of health-related quality of life and the determinants for declining or poor Health related quality of life . Design: Prospective, longitudinal cohort study. Participants: Multiple myeloma patients at all stages (newly diagnosed, first-line or second-line treatment, early or later treatment-free interval, refractory disease) from in- and outpatient units at 14 hospitals in England were recruited. In addition to clinical information and standardised Health related quality of life and psychological aspects, the Myeloma Patient Outcome Scale (MyPOS) measured palliative care concerns. Results: A total of 238 patients were recruited, on average 3.5 years ( SD: 3.4) post-diagnosis. Latent mixture growth models identified four Health related quality of life trajectories. Classes 3 and 4 represent trajectories of stable poor Health related quality of life or declining Health related quality of life over an 8-month period. The strongest predictors of poor outcome at the end of follow-up were general symptom level (odds ratio (OR): 1.3, 95% CI: 1.0–1.6, p = 0.028), presence of clinically relevant anxiety (OR: 1.2, 95% confidence interval (CI): 1.0–1.4, p = 0.019), and presence of pain (OR: 1.02, 95% CI: 1.0–1.1, p = 0.018), all being more predictive than demographic or clinical characteristics. Conclusion: General symptom level, pain and presence of anxiety predict declining Health related quality of life in multiple myeloma. Identification of patients with palliative care needs should focus on assessing patient-reported symptoms and psychosocial well-being for identifying those at risk of deterioration.

The Importance of Physical Activity in the Protection of the Mental Health of Students of Faculty of Sport Sciences

The purpose of the present research is determining the psychological symptoms observed among the students of the Faculty of Sports Sciences and to define the effects of physical activity on the mental health of the students. The sample of the research consists of 222 volunteer students (n=75 female and n=147 male) who study at Adnan Menderes University Faculty of Sports Sciences in 2017-2018 Academic Year. International Physical Activity Questionnaire (IPAQ) was used to define the physical activity levels of students and Symptom Distress Check List (SCL-90-R) was used to define the psychological symptoms of the students. SPSS 22.0 package program was used for the statistical analysis of the data collected for the present research. According to the findings of the statistical analyses, the most frequent psychological symptoms observed among students respectively were obsessive-compulsive symptoms (70.3%, n=156), paranoid thoughts (63.1%, n=140), interpersonal sensitivity (51.8%, n=115) and anger hostility (51.4%, n=114). It was also found that there was a significant negative correlation between the physical activity levels of the students and general symptom averages and the psychological symptoms such as obsessive-compulsive symptoms, depression, anxiety, anger hostility at 0.01 level (p>0.05). According to the findings of the present research, symptoms, such as obsessive-compulsive symptoms, paranoid thoughts, interpersonal sensitivity and anger hostility are observed, and general symptom average was high among students of Faculty of Sports Sciences and psychological symptoms such as obsessive-compulsive symptoms, depression, anxiety, anger hostility, phobic reaction decreased as the physical activity level of the students increased. Psychological symptoms other than psychotics were mostly among female students. Participation in meditation, yoga, music therapy, exercise and physical activity programs as well as applied lessons in the curriculum can contribute to the prevention of mental problems among students with these symptoms.

The Effect of Watson’s Human Caring Model on Meaning of Life and Symptom Management in Cancer Patients Undergoing Chemotherapy

Purpose:The purpose of this study was to determine the effect of Watson’s Human Caring Model on the meaning of life and symptom management in cancer patients undergoing chemotherapy.Design:The study was conducted using a real test model featuring a pretest and posttest and a control group.Methods:The sample consisted of 158 adult cancer patients (79 in both the experimental and control groups). The sample size was determined and the participants were allocated to groups using power analysis and a random sampling method. For the pretest, both groups completed an introductory questionnaire, the Life Attitude Profile, and the General Symptom Inventory. Then, the experimenter visited the experimental group patients’ homes three times, at 2-week intervals, to provide nursing care based on Watson’s model. Finally, after 8 weeks, a posttest was conducted by having both groups complete the Life Attitude Profile and General Symptom Inventory once again.Results:In the experimental group, the mean total posttest score for the Life Attitude Profile was determined to be 164.21 ± 36.5, and the mean total General Symptom Inventory score was 55.06 ± 13.19; however, in the control group, the mean total Life Attitude Profile score was 127.31 ± 10.61 and the mean total General Symptom Inventory score was 136.91 ± 16.20. The mean differences between the groups were statistically significant (p < .001).Implications for Practice:Care based on Watson’s model increases the sense of meaning in life and decreases symptom levels for patients undergoing chemotherapy.