Compensation to Altered Auditory Feedback in Children With Developmental Language Disorder and Typical Development

Purpose Developmental language disorder (DLD), an unexplained problem using and understanding spoken language, has been hypothesized to have an underlying auditory processing component. Auditory feedback plays a key role in speech motor control. The current study examined whether auditory feedback is used to regulate speech production in a similar way by children with DLD and their typically developing (TD) peers. Method Participants aged 6–11 years completed tasks measuring hearing, language, first formant (F1) discrimination thresholds, partial vowel space, and responses to altered auditory feedback with F1 perturbation. Results Children with DLD tended to compensate more than TD children for the positive F1 manipulation and compensated less than TD children in the negative shift condition. Conclusion Our findings suggest that children with DLD make atypical use of auditory feedback.

Crossmodal Nonspatial Repetition Inhibition Due to Modality Shift

Previous studies have found that processing of a second stimulus is slower when the modality of the first stimulus differs, which is termed the modality shift effect. Moreover, people tend to respond more slowly to the second stimulus when the two stimuli are similar in the semantic dimension, which is termed the nonspatial repetition inhibition effect. This study aimed to explore the modality shift effect on nonspatial repetition inhibition and whether such modulation was influenced by different temporal intervals. A cue–target paradigm was adopted in which modality priming and identity priming were manipulated at three interstimuli intervals. The results showed that the response times under the modality shift condition were slower than those under the modality repeat condition. In trials with modality shift, responses to congruent cues and targets were slower than to incongruent cue–target combinations, indicating crossmodal nonspatial repetition inhibition. The crossmodal nonspatial repetition inhibition effect decreased with increasing interstimuli interval. These results provide evidence that the additional intervening event proposed in previous studies is not necessary for the occurrence of crossmodal nonspatial repetition inhibition.

Exploiting delayed transitions to sustain semiarid ecosystems after catastrophic shifts

Semiarid ecosystems (including arid, semiarid and dry-subhumid ecosystems) span more than 40% of extant habitats and contain a similar percentage of the human population. Theoretical models and palaeoclimatic data predict a grim future, with rapid shifts towards a desert state, with accelerated diversity losses and ecological collapses. These shifts are a consequence of the special nonlinearities resulting from ecological facilitation. Here, we investigate a simple model of semiarid ecosystems identifying the so-called ghost, which appears after a catastrophic transition from a vegetated to a desert state once a critical rate of soil degradation is overcome. The ghost involves a slowdown of transients towards the desert state, making the ecosystem seem stable even though vegetation extinction is inevitable. We use this model to show how to exploit the ecological ghosts to avoid collapse. Doing so involves the restoration of small fractions of desert areas with vegetation capable of maintaining a stable community once the catastrophic shift condition has been achieved. This intervention method is successfully tested under the presence of demographic stochastic fluctuations.

Simulated night shift work induces circadian misalignment of the human peripheral blood mononuclear cell transcriptome

Misalignment of the endogenous circadian timing system leads to disruption of physiological rhythms and may contribute to the development of the deleterious health effects associated with night shift work. However, the molecular underpinnings remain to be elucidated. Here, we investigated the effect of a 4-day simulated night shift work protocol on the circadian regulation of the human transcriptome. Repeated blood samples were collected over two 24-hour measurement periods from eight healthy subjects under highly controlled laboratory conditions before and 4 days after a 10-hour delay of their habitual sleep period. RNA was extracted from peripheral blood mononuclear cells to obtain transcriptomic data. Cosinor analysis revealed a marked reduction of significantly rhythmic transcripts in the night shift condition compared with baseline at group and individual levels. Subsequent analysis using a mixed-effects model selection approach indicated that this decrease is mainly due to dampened rhythms rather than to a complete loss of rhythmicity: 73% of transcripts rhythmically expressed at baseline remained rhythmic during the night shift condition with a similar phase relative to habitual bedtimes, but with lower amplitudes. Functional analysis revealed that key biological processes are affected by the night shift protocol, most notably the natural killer cell-mediated immune response and Jun/AP1 and STAT pathways. These results show that 4 days of simulated night shifts leads to a loss in temporal coordination between the human circadian transcriptome and the external environment and impacts biological processes related to the adverse health effects associated to night shift work.

The threat of increasing diversity: Why many White Americans support Trump in the 2016 presidential election

What accounts for the widespread support for Donald Trump in the 2016 U.S. presidential race? This experiment demonstrates that the changing racial demographics of America contribute to Trump’s success as a presidential candidate among White Americans whose race/ethnicity is central to their identity. Reminding White Americans high in ethnic identification that non-White racial groups will outnumber Whites in the United States by 2042 caused them to become more concerned about the declining status and influence of White Americans as a group (i.e., experience group status threat), and caused them to report increased support for Trump and anti-immigrant policies, as well as greater opposition to political correctness. Increased group status threat mediated the effects of the racial shift condition on candidate support, anti-immigrant policy support, and opposition to political correctness. Among Whites low in ethnic identification, in contrast, the racial shift condition had no effect on group status threat or support for anti-immigrant policies, but did cause decreased positivity toward Trump and decreased opposition to political correctness. Group status threat did not mediate these effects. Reminders of the changing racial demographics had comparable effects for Democrats and Republicans. Results illustrate the importance of changing racial demographics and White ethnic identification in voter preferences and how social psychological theory can illuminate voter preferences.

Catalytic Activity of PILCS for Water Gas Shift Reaction of CO

Montmorillonite pillared by mixing Fe, Fe-Cr, Al-Fe and Cu-Al complexes was investigated for their catalytic activities for Water Gas Shift Reaction (WGSR). Element chemical analysis showed that the content of Fe, Fe-Cr, Al-Fe catalysts were 26.93%, 31.03%, 28.20%, respectively. Compared with the traditional shift catalyst, in the same shift condition, we can use the PILC catalysts to substitute. Using PILC catalysts can accurately control the constitution of synthesis gas over changing shift rate.