3D Printing of Artificial Skin Patches with Bioactive and Optically Active Polymer Materials for Anti-Infection and Augmenting Wound Repair

Inspired by the skin biofunction of protecting the body from microorganism invasion, artificially manufacturing human skin in vitro with promising antibacterial capability and cell affinity is urgently required in wound...

Synthesis of an optically active polymer containing a planar phthalimide backbone by asymmetric polymerization

Herein we present the precise design and synthesis of a novel polymer backbone that induces a helical structure through asymmetric polymerization reactions of a phthalimide-based monomer catalyzed by a planar-chiral cyclopentadienyl–ruthenium complex.

Chiral helical disubstituted polyacetylenes form optically active particles through precipitation polymerization

Preparation of optically active polymer particles constructed by chiral helical disubstituted polyacetylenes via precipitation polymerization.

Configurational Molecular Glue: One Optically Active Polymer Attracts Two Oppositely Configured Optically Active Polymers

D-configured poly(D-lactic acid) (D-PLA) and poly(D-2-hydroxy-3-methylbutanoic acid) (D-P2H3MB) crystallized separately into their homo-crystallites when crystallized by precipitation or solvent evaporation, whereas incorporation of L-configured poly(L-2-hydroxybutanoic acid) (L-P2HB) in D-configured D-PLA and D-P2H3MB induced co-crystallization or ternary stereocomplex formation between D-configured D-PLA and D-P2H3MB and L-configured L-P2HB. However, incorporation of D-configured poly(D-2-hydroxybutanoic acid) (D-P2HB) in D-configured D-PLA and D-P2H3MB did not cause co-crystallization between D-configured D-PLA and D-P2H3MB and D-configured D-P2HB but separate crystallization of each polymer occurred. These findings strongly suggest that an optically active polymer (L-configured or D-configured polymer) like unsubstituted or substituted optically active poly(lactic acid)s can act as “a configurational or helical molecular glue” for two oppositely configured optically active polymers (two D-configured polymers or two L-configured polymers) to allow their co-crystallization. The increased degree of freedom in polymer combination is expected to assist to pave the way for designing polymeric composites having a wide variety of physical properties, biodegradation rate and behavior in the case of biodegradable polymers.