“Lesões de células gigantes” dos maxilares: possibilidades e limitações do diagnóstico histológico

The authors studied the «giant cell lesions» calling attention for the necessity of submit X rays and a good clinic history to the patologist. They believe not in the diferencial diagnosis, in histologic level, between giant cell reparative granuloma and Done manifestations of hyperparatireoidism. In such cases blood chemistry has the last word. They believe in the histologic identification of the true giant cell tumor. Also in the histologic identification of cherubism, but consider easy in this case, the simultaneous study of the x rays and clinical history.

Giant Cell Reparative Granuloma Presented as Nasal Mass: A Rare Entity

Giant Cell Reparative Granuloma (GCRG) is an unusual non-neoplastic lesion which most commonly involves maxilla and mandible. We present a case of GCRG of the nasal cavity in a young female presented with the complaint of progressively nasal obstruction. Radiological findings are usually nonspecific in this entity, therefore a good clinical, radiological and pathological correlation is needed for final diagnosis and to differentiate it from other giant cell lesions. Surgical excision is the preferred treatment modality over simple curettage.

Resection and Reconstruction is the Procedure of Choice for Giant Cell Lesions of Small Bones: A Case Report and Literature Review

Background: Giant cell lesion of small bones (GCLSB), also known as giant cell reparative granuloma, is a rare tumor-like condition occurring in the small bones of the hands and feet. GCLSB lacks specific clinical, radiological, and histological manifestations. There are no standardized protocols for treatment. Case presentation: Here, we report a 16-year-old male with recurrent GCLSB in the proximal phalanx of the left thumb. The lesion was successfully resected with bone grafting. Conclusions: We summarized the characteristics of 33 reported cases of GCLSB from 1983 to date, including gender, age, lesion sites, recurrence, and treatment. We conclude that resection and reconstruction with curettage is the treatment of choice.

Giant Cell Reparative Granuloma of the Orbit: Clinicopathological Characteristics and Treatment

Giant cell reparative granuloma (GCRG) is a rare fibroosseous lesion uncommonly seen in the orbital area. Although benign, it is known to be recurrent and locally destructive. We report two cases of GCRG of the orbit. In both cases, computed tomography revealed a heterogeneously growing well-defined mass, arising from the roof of the orbit, affecting the cortex, and invading the orbit. In the first case, the mass extended into the anterior cranial fossa. Magnetic resonance imaging with gadolinium showed, in both cases, a cystic character of the lesion with fluid levels. The surgical treatment was performed via an upper crease incision. An ultrasonic aspirator system was used to remove the tumor tissue and its extension into cranial fossa. Careful histopathologic analysis established the diagnosis of GCRG. Symptoms resolved completely with no evidence of recurrence after a follow-up of 18 and 14 months, respectively. We present the clinicopathological and radiological findings, and we describe the surgical approach. As a rare entity, GCRG of the orbit should be considered in differential diagnosis of fibroosseous orbital masses. Complete surgical excision carries a low risk of recurrence.

PRIMARY GIANT CELL-RICH LESIONS OF BONE WITH ROLE OF DENOSUMABHISTOPATHOLOGICAL STUDY WITH CLINICO-RADIOLOGICAL CORRELATION

Introduction: The diagnosis of primary giant cell-rich lesion of bone is often difficult even for experienced pathologist. The diagnostic histological features are: multinucleated osteoclast-like giant cell and a mononuclear stroma. But sometimes, from the histological picture alone, it is difficult to differentiate between different lesions such as a Giant -cell tumour of bone, Aneurysmal Bone Cyst and Giant-cell Reparative Granuloma. Many of these lesions show some characteristic features such as typical anatomic location and age of the patient, which are also important supporting factor for diagnosis. Hence histopathological study with clinico-radiological correlation is mandatory for precise and accurate diagnosis. These parameters are important for the treatment and prognosis of these lesions. Aims & objective: Aims of the study were, to study Histopathology of Primary Giant cell-rich lesion of bone, to study the clinico-radiological correlation in these lesions & to study the diagnostic utility of findings these lesions. Material & method: In the present study, we have retrospectively examined 50 cases of primary giant-cell rich lesions of bone using biopsy tissue and large resected tissue material. All patients were diagnosed and treated at our institute from October 2019 to September 2020. Patients’ details, Clinical Examination, Histopathological Examination, Radiological details were studied and correlated. Result & conclusion: Common lesions under this category were Giant Cell Tumour of Bone (41), Aneurysmal Bone Cyst (04), Giant Cell-Rich Osteosarcoma, Giant Cell Reparative Granuloma (02), and Fibrous Dysplasia (01). Detailed Histopathological study and clinic-radiological correlation is very helpful to arrive at precise and accurate diagnosis. This in turn, is very helpful for precise treatment of these patients and to know the prognosis of these patients.