HIV Uninfected Conception in Serodiscordant Couple: Case Reports

With the advances in assisted reproductive techniques, there are various methods to decrease the risk of HIV viral transmission by separating out uninfected sperm cells from viral reservoirs known to exist within the semen. We report two successful pregnancies in HIV-serodiscordant couples by using assisted reproductive technique i.e in vitro fertilization (IVF).

Strategi monitoring kepatuhan penggunaan antiretroviral pre-exposure prophilaxis pada pasangan serodiscordant

Monitoring strategy of antiretroviral pre-exposure prophylaxis adherence among serodiscordant couple Antiretroviral pre-exposure prophylaxis (PrEP) has been recommended as HIV prevention but poor medical adherence can cause suboptimal therapy. This study explored the strategies of monitoring PrEP adherence among the serodiscordant couples. This systematic review based on 4 data bases (Scopus, Pubmed, Ebsco and Sage Journal), included clinical trial studies articles between 2013-2018, in English, and available in full-text. Papers, which not met the inclusion criteria, will be excluded. Keywords used in this study are ‘serodiscordant couple’ AND ‘method’ OR ‘strategy’ OR ‘approach’ AND ‘pre-exposure prophylaxis intention’ OR ‘pre-exposure prophylaxis adherence’. This study discovered various strategies applied based on the type of delivering process, the variance of dose, and variance of preference of the couple. Preference of PrEP dose and type of application related to heterosexual or homosexual orientation and their social commitment. The paper explains the advantage of M-health and biomarker level monitoring.

Outcome of Intra Uterine Insemination for HIV Serodiscordant Couple

<p><strong>Introduction</strong></p><p>HIV serodiscordant couple who wish to have offspring but fear of disease contagious prohibittedthem from concieved naturally. Intrauterine insemination without having direct sexual contact is one of the method to achieve this wish. This study was aimed to evaluate the outcome of intrauterine insemination in HIV serodiscordant couple.</p><p><strong>Material and methods</strong></p><p>Retrospective analytic study was done. HIV serodiscordant couple who have been treated with intrauterine insemination from January 2010 until June 2014 in Halim Fertility Centre Medan was included in this study.</p><p><strong>Results</strong></p><p>There were 27 cycles of intrauterine insemination from HIV serodiscordant couple. The clinical pregnancy rate were 33.3%. None of the babies or mother after deliveries have HIV positive.</p><p><strong>Conclusion</strong></p><p>Intrauterine insemination in HIV serodiscordant couple appears to be effective and safe method to achieve pregnancy. </p>