Inferior Extensions of the Atrioventricular Node

The pathways for excitation of the atrioventricular node enter either superiorly, as the so-called ‘fast’ pathway, or inferiorly as the ‘slow’ pathway. However, knowledge of the specific anatomical details of these pathways is limited. Most of the experimental studies that established the existence of these pathways were conducted in mammalian hearts, which have subtle differences to human hearts. In this review, the authors summarise their recent experiences investigating human cardiac development, correlating these results with the arrangement of the connections between the atrial myocardium and the compact atrioventricular node as revealed by serial sectioning of adult human hearts. They discuss the contributions made from the atrioventricular canal myocardium, as opposed to the primary ring. Both these rings are incorporated into the atrial vestibules, albeit with the primary ring contributing only to the tricuspid vestibule. The atrial septal cardiomyocytes are relatively late contributors to the nodal inputs. Finally, they relate our findings of human cardiac development to the postnatal arrangement.

New Insights into the Development and Morphogenesis of the Cardiac Purkinje Fiber Network: Linking Architecture and Function

The rapid propagation of electrical activity through the ventricular conduction system (VCS) controls spatiotemporal contraction of the ventricles. Cardiac conduction defects or arrhythmias in humans are often associated with mutations in key cardiac transcription factors that have been shown to play important roles in VCS morphogenesis in mice. Understanding of the mechanisms of VCS development is thus crucial to decipher the etiology of conduction disturbances in adults. During embryogenesis, the VCS, consisting of the His bundle, bundle branches, and the distal Purkinje network, originates from two independent progenitor populations in the primary ring and the ventricular trabeculae. Differentiation into fast-conducting cardiomyocytes occurs progressively as ventricles develop to form a unique electrical pathway at late fetal stages. The objectives of this review are to highlight the structure–function relationship between VCS morphogenesis and conduction defects and to discuss recent data on the origin and development of the VCS with a focus on the distal Purkinje fiber network.

STUDY ON THE ROLE OF DRIVING SKILLS IN PHYSICAL EDUCATION LESSON AT PRIMARY RING

Physical education and sport know nowadays an unprecedented development. And effectively contributing directly to the formation and development of fair and multilateral personality, they exert remarkable influence in the direction of preserving and improving health, and spiritual potential of students biomotric tackling sedentary specific harmful influences. Between physical education and other educational branches (the intellectual, emotional, moral-volitional, aesthetics) there is a definite connection.The practicality of physical education, active presence of students during lessons, countless repetitions of exercises, solutions, behaviors, gestures, attitudes, etc. enable physical exercise influences the orientation towards the major goals of education. Physical education is used as a teaching aid in the formation and development of basic skills, skills, habits, skills and traits with broad-value in everyday activity of students. Knowing children's passion for movement, play and sports activities, our duty to capitalize channel influences exercise correctly so, with strengthening the body, the personality of the child to be positively influenced morally, emotionally and intellectually.

Gravitational lensing by regular black holes surrounded by plasma

In the weak field approximation, we study the gravitational lensing near the regular Bardeen, Hayward and Ayon-Beato–Garcia (ABG) black holes surrounded by plasma. The exact expressions for the deflection angle of the photons due to the effect of the gravitational field and the plasma have been obtained. The analysis of the image source brightness magnification in the background spacetimes of (i) Bardeen, (ii) Hayward and (iii) ABG regular black holes have shown that the increase of the corresponding charge of regular black hole causes the increase in the magnification of the source image. In addition to the primary ring, one may observe the secondary ring with smaller magnification. The influence of the plasma with (i) constant and (ii) radial power law electron density to the magnification of the source image has been studied.

On Semi-Primary Self-Injective Rings and Faith's Quasi-Frobenius Conjecture

A long-standing conjecture of Faith in ring theory states that a left self-injective semi-primary ring A is necessarily a quasi-Frobenius ring. We propose a new method for approaching this conjecture, and prove it under some mild conditions; we show that if the simple A-modules are at most countably generated over a subring of the centre of A, then the conjecture holds. Also, the conjecture holds for algebras A over sufficiently large fields, i.e. if the cardinality of is larger than the dimension of the simple A-modules (or of A/Jac(A)). This effectively proves the conjecture in many situations, and we obtain several previously known results on this problem as a consequence.

High-Reliable WDM Optical Access Network Expanding by Double-Fiber-Tangent Ring

A WDM optical access network architecture based on double-fiber-tangent rings is proposed. With the proposed architecture, both data convergence and link protection can be realized. OLT and RNs can automatically switch to protection mode to overcome fiber failure occurring no matter in both primary ring (PR) and sub-ring (SR). The RNs designed as tangent points can realize wavelengths adding and dropping between PR and SR, and they also can realize network expansion through adding more wavelengths. In addition to this, the design of double-fiber ring can better the survivability and self-healing ability of the network.

Numerical study of a vortex ring impacting a flat wall

We numerically study a vortex ring impacting a flat wall with an angle of incidence θ ≥ 0°) in three dimensions by using the lattice Boltzmann equation. The hydrodynamic behaviour of the ring–wall interacting flow is investigated by systematically varying the angle of incidence θ in the range of 0° ≤ θ ≤ 40° and the Reynolds number in the range of 100 ≤ Re ≤ 1000, where the Reynolds number Re is based on the translational speed and initial diameter of the vortex ring. We quantify the effects of θ and Re on the evolution of the vortex structure in three dimensions and other flow fields in two dimensions. We observe three distinctive flow regions in the θ–Re parameter space. First, in the low-Reynolds-number region, the ring–wall interaction dissipates the ring without generating any secondary rings. Second, with a moderate Reynolds number Re and a small angle of incidence θ, the ring–wall interaction generates a complete secondary vortex ring, and even a tertiary ring at higher Reynolds numbers. The secondary vortex ring is convected to the centre region of the primary ring and develops azimuthal instabilities, which eventually lead to the development of hairpin-like small vortices through ring–ring interaction. And finally, with a moderate Reynolds number and a sufficiently large angle of incidence θ, only a secondary vortex ring is generated. The secondary vortex wraps around the primary ring and propagates from the near end of the primary ring, which touches the wall first, to the far end, which touches the wall last. The rings develop a helical structure. Our results from the present study confirm some existing experimental observations made in the previous studies.

Effects of mechanical loading on early conduction system differentiation in the chick

The primary ring, a horseshoe-shaped structure situated between the left and right ventricle and connected superiorly to the atrioventricular canal, is the first specialized fast ventricular conduction pathway in the embryonic heart. It has been first defined immunohistochemically and is characterized as a region of slow myocyte proliferation. Recent studies have shown that it participates in spreading the ventricular electrical activation during stages preceding ventricular septation in the mouse, chick, and rat. Here we demonstrate its presence using optical mapping in chicks between embryonic days (ED) 3–5. We then tested the effects of hemodynamic unloading in the organ culture system upon its functionality. In ED3 hearts cultured without hemodynamic loading for 24 h, we observed a significant decrease in the percentage activated through the primary ring conduction pathway. A morphological examination revealed arrested growth, collapse, and elongation of the outflow tract and disorganized trabeculation. A similar reversal toward more primitive activation patterns was observed with culture between ED4 and ED5. This phenotype was completely rescued with the artificial loading of the ventricles with a droplet of silicone oil. We conclude that an appropriate loading is required during the early phases of the conduction system formation and maturation.

Friction and Wear Studies Using Taguchi Method: Application to the Characterization of Carbon-Silicon Carbide Tribological Couples of Automotive Water Pump Seals

An experimental design based on the Taguchi method has been applied to optimize the use of a dynamic sealing element of water pump of automotives combustion engines. A carbon primary ring and a silicon carbide mating ring set up this dynamic sealing element. The aim of this work was to experimentally determine the crossed influence of the primary ring variant, the normal load, the surrounding, the mating ring finishing, and the rotational frequency on the dynamic friction coefficient and on the wear of carbon primary ring-silicon carbide mating ring tribological couples. The coefficient of dynamic friction and the wear depend on the design factors. They are also functions of the interactions between these experimental factors, from the implementation of an experimental design. The results obtained allow the optimal functioning condition to be determined and the best friction couple to be used for a given dynamic sealing application.