Resting-State Networks Associated with Behavioral and Self-Reported Measures of Persecutory Ideation in Psychosis

Persecutory ideations are self-referential delusions of being the target of malevolence despite a lack of evidence. Wisner et al. (2021) found that reduced connectivity between the left frontoparietal (lFP) network and parts of the orbitofrontal cortex (OFC) correlated with increased persecutory behaviors among psychotic patients performing in an economic social decision-making task that can measure the anticipation of a partner’s spiteful behavior. If this pattern could be observed in the resting state, it would suggest a functional-structural prior predisposing individuals to persecutory ideation. Forty-four patients in the early course of a psychotic disorder provided data for resting-state functional connectivity magnetic resonance imaging across nine brain networks that included the FP network and a similar OFC region. As predicted, we found a significant and negative correlation between the lFP–OFC at rest and the level of suspicious mistrust on the decision-making task using a within-group correlational design. Additionally, self-reported persecutory ideation correlated significantly with the connectivity between the right frontoparietal (rFP) network and the OFC. We extended the previous finding of reduced connectivity between the lFP network and the OFC in psychosis patients to the resting state, and observed a possible hemispheric difference, such that greater rFP–OFC connectivity predicted elevated self-reported persecutory ideation, suggesting potential differences between the lFP and rFP roles in persecutory social interactions.

Morphometry Difference of the Hippocampal Formation Between Blind and Sighted Individuals

The detailed morphometry alterations of the human hippocampal formation (HF) for blind individuals are still understudied. 50 subjects were recruited from Yantai Affiliated Hospital of Binzhou Medical University, including 16 congenital blindness, 14 late blindness, and 20 sighted controls. Volume and shape analysis were conducted between the blind (congenital or late) and sighted groups to observe the (sub)regional alterations of the HF. No significant difference of the hippocampal volume was observed between the blind and sighted subjects. Rightward asymmetry of the hippocampal volume was found for both congenital and late blind individuals, while no significant hemispheric difference was observed for the sighted controls. Shape analysis showed that the superior and inferior parts of both the hippocampal head and tail expanded, while the medial and lateral parts constrained for the blind individuals as compared to the sighted controls. The morphometry alterations for the congenital blind and late blind individuals are nearly the same. Significant expansion of the superior part of the hippocampal tail for both congenital and late blind groups were observed for the left hippocampi after FDR correction. Current results suggest that the cross-model plastic may occur in both hemispheres of the HF to improve the navigation ability without the stimuli of visual cues, and the alteration is more prominent for the left hemisphere.

The impact of spatially varying wetland source signatures on the atmospheric variability of δ D-CH 4

We present the first spatially resolved distribution of the δ D-CH 4 signature of wetland methane emissions and assess its impact on atmospheric δ D-CH 4 . The δ D-CH 4 signature map is derived by relating δ D-H 2 O of precipitation to measured δ D-CH 4 of methane wetland emissions at a variety of wetland types and locations. This results in strong latitudinal variation in the wetland δ D-CH 4 source signature. When δ D-CH 4 is simulated in a global atmospheric model, little difference is found in global mean, inter-hemispheric difference and seasonal cycle if the spatially varying δ D-CH 4 source signature distribution is used instead of a globally uniform value. This is because atmospheric δ D-CH 4 is largely controlled by OH fractionation. However, we show that despite these small differences, using atmospheric records of δ D-CH 4 to infer changes in the wetland emissions distribution requires the use of the more accurate spatially varying δ D-CH 4 source signature. We find that models will only be sensitive to changes in emissions distribution if spatial information can be exploited through the spatially resolved source signatures. In addition, we also find that on a regional scale, at sites measuring excursions of δ D-CH 4 from background levels, substantial differences are simulated in atmospheric δ D-CH 4 if using spatially varying or uniform source signatures. This article is part of a discussion meeting issue ‘Rising methane: is warming feeding warming? (part 1)’.

Large hemispheric difference in ultrafine aerosol concentrations in the lowermost stratosphere

<p>On the NASA Atmospheric Tomography Mission (ATom), we observed a sharp hemispheric contrast in the concentration of ultrafine aerosols (3-12 nm diameter) in the lowermost stratosphere that persisted through all four seasons. Exploring possible causes, we show that this is likely caused by aircraft, which emit both ultrafine aerosol and precursor gases for new particle formation (NPF) in quantities that agree well with our observations. While aircraft may emit a range of NPF precursors, we focus here on sulphur dioxide (a major source of atmospheric sulphuric acid), of which we have observations from the same mission.  We observe the same hemispheric contrast in sulphur dioxide as ultrafine aerosol, and find that the observed concentrations are in alignment with inventoried aircraft emissions. We present box modeling and thermodynamic calculations that support the plausibility of NPF under the conditions and sulphur dioxide concentrations observed on ATom.</p><p>While the direct climate impact of ultrafine aerosol in the lowermost stratosphere (LMS) may currently be small, our observations show a definitive size distribution shift of the background aerosol distribution in the northern hemisphere. This is important for assessing aviation impacts, and the expected impacts of increased air-traffic. Furthermore, climate intervention via injection of sulphate or aerosols into the stratosphere is a current subject of research. Our study shows that NPF is possible and likely already happening in the LMS, which must be accounted for in models for stratospheric modification, and points out that we must consider that any intentional stratospheric modification will be applied to two very different hemispheres: a largely pristine southern hemisphere; and an already anthropogenically modified northern hemisphere.</p>

Persistence and variability of Earth's inter-hemispheric albedo symmetry

<p>Earth's albedo is observed to be symmetric about the equator on long time scales despite having an asymmetric distribution of land and aerosol sources between the northern and southern hemispheres. This is made possible by the distribution of clouds, which compensates the clear-sky albedo asymmetry almost exactly. We investigate the variability of the inter-hemispheric difference in reflected solar radiation (asymmetry) on the monthly time scale using decomposed reflected radiative fluxes in the CERES EBAF satellite data record. We find that the variations in the degree of symmetry on shorter timescales is strongly controlled by tropical and subtropical processes affecting cloud distributions. States of high asymmetry coincide with opposing phases of the El Niño-Southern Oscillation (ENSO); during El Niño (La Niña) conditions, the southern (northern) hemisphere is reflecting anomalously more than the other, perturbing the inter-hemispheric albedo symmetry. This perturbation also impacts the inter-hemispheric difference in net radiative fluxes, i.e. during states of asymmetry, the hemisphere that is reflecting less solar radiation also absorbs more energy in the net radiation balance.</p><p>We also compare the variability of the asymmetry in simulations from coupled models in Phase 6 of the Coupled Model Intercomparison Project with observations, and find that model mean asymmetry bias is primarily determined by biases in reflected radiation in the midlatitudes. Models that overestimate the variability of the asymmetry also have larger biases in reflected radiation over the tropics. Both bias and variability are generally improved in atmospheric model simulations driven with historical sea surface temperatures.</p>

Human Sound Localization Depends on Sound Intensity: Implications for Sensory Coding

A fundamental question of human perception is how we perceive target locations in space. Through our eyes and skin, the activation patterns of sensory organs provide rich spatial cues. However, for other sensory dimensions, including sound localization and visual depth perception, spatial locations must be computed by the brain. For instance, interaural time differences (ITDs) of the sounds reaching the ears allow listeners to localize sound in the horizontal plane. Our experiments tested two prevalent theories on how ITDs affect human sound localization: 1) the labelled-line model, encoding space through tuned representations of spatial location; versus 2) the hemispheric-difference model, representing space through spike-rate distances relative to a perceptual anchor. Unlike the labelled-line model, the hemispheric-difference model predicts that with decreasing intensity, sound localization should collapse toward midline reference, and this is what we observed behaviorally. These findings cast doubt on models of human sound localization that rely on a spatially tuned map. Moreover, analogous experimental results in vision indicate that perceived depth depends upon the contrast of the target. Based on our findings, we propose that the brain uses a canonical computation of location across sensory modalities: perceived location is encoded through population spike rate relative to baseline.

The 2009–2010 step in atmospheric CO₂ inter-hemispheric difference

The annual average CO2 difference between baseline data from Mauna Loa and the Southern Hemisphere increased by ∼ 0.8 μmol mol−1 (0.8 ppm) between 2009 and 2010, a step unprecedented in over 50 years of reliable data. We find no evidence for coinciding, sufficiently large and rapid, source/sink changes. A statistical anomaly is unlikely due to the highly systematic nature of the variation in observations. An explanation for the step, and the subsequent 5 year stability in this north–south difference, involves inter-hemispheric atmospheric exchange variation. The selected data describing this episode provide a critical test for studies that employ atmospheric transport models that interpret global carbon budgets and inform management of anthropogenic emissions.