Neuroadaptation in the system of emotional reinforcement under alcohol dependence

The article is addressed to the problem of neuroadaptation in the brain system of emotional reinforcement under alcohol dependence. The level of anxiety, the functional state of the positive emotional reinforcement system, the electrogenesis of the structures of the brain limbic-neocortical system, levels of dopamine in n.accumbens and hypothalamus were studied in an experiment on animals. Particular attention is paid to the transcutaneous allotransplantation of the embryonic hippocampal tissue as a biological approach to suppressing of craving for alcohol intake. It has been shown that allotransplantation reduces alcohol motivation by restructuring of neurophysiological and neurochemical mechanisms in the system of positive reinforcement. Key words: alcohol dependence model, electrical activity of the brain, emotional system of the brain, transcutaneousallotransplantation of embryonic tissue,dopamine

Correlation between learning and alcoholization in rats

The aim of this work was to investigate the relationship between the processes of learning and innate behaviour and alcohol abuse in young male rats. Rats differed in the degree of alcohol motivation and had different combinations of training in maze with alcoholization. In general it was found that compared to nondependent animals, alcohol-dependent rats were characterized by much higer emotionality, anxiety, lower locomotor activity, and research activity. The most negative influence of alcohol abuse on the behaviour was shown in animals with low innate activity (locomotor, emotional, and exploratory activity), which were poorly trained in the maze. It was shown that training rats in the maze before alcohol abuse had a positive effect on the behaviour (slightly reduced the amount of alcohol-preferring animals). Alcoholization before training increased the level of anxiety and neurotic reactions in animals, especially in rats, which had poorly trained in maze before alcoholization. Alcoholization of animals before the start of training increased the level of anxiety and neurotic reactions in alcoholized rats, especially in those that were poorly trained in the maze before alcoholization.