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Solution-phase synthesis and biological evaluation of triostin A and its analogues

2016 ◽  
Vol 14 (6) ◽  
pp. 2090-2111 ◽  
Author(s):  
Kozo Hattori ◽  
Kota Koike ◽  
Kensuke Okuda ◽  
Tasuku Hirayama ◽  
Masahiro Ebihara ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Biological Evaluation ◽  
Solution Phase ◽  
Phase Synthesis ◽  
Total Syntheses ◽  
Solution Phase Synthesis ◽  
Triostin A ◽  
Inhibitory Activities ◽  
High Yields ◽  
Synthesis And Biological Evaluation

We have accomplished preparative solution-phase total syntheses of triostin A (17.5% in 13 steps) and its analogues with high yields to demonstrate their significant inhibitory activities on HIF-1 activation and cell proliferation.

scholarly journals Triostin A Derived Cyclopeptide as Architectural Template for the Alignment of Four Recognition Units

ChemistryOpen ◽  
2014 ◽  
Vol 3 (4) ◽  
pp. 152-160 ◽  
Author(s):  
Ursula M. Kotyrba ◽  
Kevin Pröpper ◽  
Eike-F. Sachs ◽  
Anastasiya Myanovska ◽  
Tobias Joppe ◽  
...  
Keyword(s):  
Triostin A

scholarly journals Triostin A derived hybrid for simultaneous DNA binding and metal coordination

Amino Acids ◽  
2010 ◽  
Vol 41 (2) ◽  
pp. 449-456 ◽  
Author(s):  
Eike-F. Sachs ◽  
André Nadler ◽  
Ulf Diederichsen
Keyword(s):  
Dna Binding ◽  
Metal Coordination ◽  
Triostin A

scholarly journals Binding Kinetics of Bisintercalator Triostin A with Optical Tweezers Force Mechanics

2009 ◽  
Vol 97 (10) ◽  
pp. 2780-2784 ◽  
Author(s):  
Christoph Kleimann ◽  
Andy Sischka ◽  
Andre Spiering ◽  
Katja Tönsing ◽  
Norbert Sewald ◽  
...  
Keyword(s):  
Optical Tweezers ◽  
Binding Kinetics ◽  
Triostin A ◽  
Kinetics Of

Syntheses of Triostin A Antibiotic and Nucleobase-Functionalized Analogs as New DNA Binders

2009 ◽  
Vol 2009 (28) ◽  
pp. 4801-4809 ◽  
Author(s):  
Anmol Kumar Ray ◽  
Ulf Diederichsen
Keyword(s):  
Triostin A ◽  
Dna Binders

Origin of slow conformer conversion of triostin A and interaction ability with nucleic acid bases

2009 ◽  
Vol 21 (5) ◽  
pp. 541-545 ◽  
Author(s):  
NAOKI HIGUCHI ◽  
YOSHIMASA KYOGOKU ◽  
MASARU SHIN ◽  
KEN INOUYE
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acid Bases ◽  
Triostin A

scholarly journals Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics fromStreptomyces triostinicus

2008 ◽  
Vol 24 (6) ◽  
pp. 1226-1231 ◽  
Author(s):  
Alex P. Praseuth ◽  
Clay C. C. Wang ◽  
Kenji Watanabe ◽  
Kinya Hotta ◽  
Hiroki Oguri ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Biosynthetic Gene Cluster ◽  
Complete Sequence ◽  
Biosynthetic Gene ◽  
Triostin A

scholarly journals Enzymatic Macrolactonization in the Presence of DNA Leading to Triostin A Analogs

2008 ◽  
Vol 15 (8) ◽  
pp. 818-828 ◽  
Author(s):  
Kento Koketsu ◽  
Hiroki Oguri ◽  
Kenji Watanabe ◽  
Hideaki Oikawa
Keyword(s):  
Triostin A

Protection by Conformationally Restricted Mobility: First Solid-Phase Synthesis of Triostin A

2008 ◽  
Vol 14 (15) ◽  
pp. 4475-4478 ◽  
Author(s):  
Judit Tulla-Puche ◽  
Eleonora Marcucci ◽  
Manuel Fermin ◽  
Núria Bayó-Puxan ◽  
Fernando Albericio
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Conformationally Restricted ◽  
Triostin A ◽  
Restricted Mobility
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