horse heart cytochrome c
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2021 ◽  
Vol 22 (19) ◽  
pp. 10551
Author(s):  
Francesca Sacco ◽  
Matteo Tarchi ◽  
Giarita Ferraro ◽  
Antonello Merlino ◽  
Giorgio Facchetti ◽  
...  

Three novel platinum(II) complexes bearing N-heterocyclic ligands, i.e., Pt2c, Pt-IV and Pt-VIII, were previously prepared and characterized. They manifested promising in vitro anticancer properties associated with non-conventional modes of action. To gain further mechanistic insight, we have explored here the reactions of these Pt compounds with a few model proteins, i.e., hen egg white lysozyme (HEWL), bovine pancreatic ribonuclease (RNase A), horse heart cytochrome c (Cyt-c) and human serum albumin (HSA), primarily through ESI MS analysis. Characteristic and variegate patterns of reactivity were highlighted in the various cases that appear to depend both on the nature of the Pt complex and of the interacting protein. The protein-bound Pt fragments were identified. In the case of the complex Pt2c, the adducts formed upon reaction with HEWL and RNase A were further characterized by solving the respective crystal structures: this allowed us to determine the exact location of the various Pt binding sites. The implications of the obtained results are discussed in relation to the possible mechanisms of action of these innovative anticancer Pt complexes.


2021 ◽  
Vol 548 ◽  
pp. 74-77
Author(s):  
Rita V. Chertkova ◽  
Alexander M. Firsov ◽  
Elena A. Kotova ◽  
Ivan D. Gusev ◽  
Dmitry A. Dolgikh ◽  
...  

Metallomics ◽  
2018 ◽  
Vol 10 (5) ◽  
pp. 768-768
Author(s):  
Carolin Mügge ◽  
Elena Michelucci ◽  
Francesca Boscaro ◽  
Chiara Gabbiani ◽  
Luigi Messori ◽  
...  

Correction for ‘Reactions of metallodrugs with proteins: selective binding of phosphane-based platinum(ii) dichlorides to horse heart cytochrome c probed by ESI MS coupled to enzymatic cleavage’ by Carolin Mügge et al., Metallomics, 2011, 3, 987–990.


2014 ◽  
Vol 19 (7) ◽  
pp. 1195-1201 ◽  
Author(s):  
Paolo Ascenzi ◽  
Maria Marino ◽  
Fabio Polticelli ◽  
Roberto Santucci ◽  
Massimo Coletta

2013 ◽  
Vol 104 (1) ◽  
pp. 163-172 ◽  
Author(s):  
Yusuke Miyashita ◽  
Tetsuichi Wazawa ◽  
George Mogami ◽  
Satoshi Takahashi ◽  
Yoshihiro Sambongi ◽  
...  

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