498 Oxidative stress and left ventricular performance in patients according to different glycometabolic phenotypes

Recent studies demonstrated that in normoglucose-tolerant subjects (NGT), 1-h post load plasma glucose value ≥155 mg/dL, during OGTT, identifies a worse cardio-metabolic risk profile with increased risk for Type 2 Diabetes Mellitus (T2DM). T2DM patients present increased oxidative stress, due to high blood glucose levels, which plays a central role in the development of CV events. The aim of our study was to evaluate the correlation between oxidative stress and subclinical myocardial damage, assessed with speckle tracking echocardiography, in NGT patients with 1-h post load ≥155 mg/dL vs. NGT < 155 subjects, impaired glucose tolerance (IGT) and T2DM patients. We enrolled 100 Caucasian patients (61 M, 39 W, mean age 61.4 ± 10.7) afferent to CATAMERI study. Main exclusion criteria were CV complications, history of malignant or chronic respiratory disease, alcohol, drug influencing glucose metabolism or smoking abuse. All subjects underwent clinical and laboratory evaluation, OGTT and HOMA-IR. The serum values of the markers of oxidative stress (8-isoprostane and NOX-2) were assessed with ELISA sandwich. Statistical analysis was performed with ANOVA test, linear correlation analysis and stepwise multivariate linear regression model. According to OGTT results, subjects were divided into 4 groups: NGT < 155 (n = 30), NGT ≥ 155 (n = 24), IGT (n = 28), T2DM (n = 18). Serum levels of 8-isoprostane and NOX-2 were significantly increased (P < 0.0001) in NGT ≥ 155 compared to NGT < 155 group, but similar with IGT, indicating an increase in oxidative stress with the worsening of the metabolic status. The left global systolic function, evaluated as myocardial deformation and global longitudinal strain (GLS), appeared progressively lower proceeding from the NGT < 155 group to the T2DM group (P < 0.0001). Moreover, for similar values of ejection fraction (EF), NGT ≥ 155 subjects presented reduced GLS compared to NGT < 155 (P = 0.001), but similar to IGT patients. The linear correlation analysis showed that endo/epi ratio was significantly and inversely correlated with 1 h post load glycaemia (r = −0.632, P < 0.0001), NOX-2 (r = −0.638, P < 0.0001), 8-isoprostane (r = −0.508, P < 0.0001); GLS was inversely correlated with 1 h post load glycaemia (r = −0.734, P < 0.0001) and directly and significantly correlated with 8-isoprostane (r = 0.564, P < 0.0001), NOX-2 (r = 0.625, P < 0.0001). From stepwise multivariate linear regression model, NOX-2 resulted the major predictor of endo/epi ratio, justifying 40.7% of its variation. 1-h post load glycaemia was the second predictor of endo/epi ratio justifying another 9.2% of its variation. Similarly 1-h post load glycaemia was the strongest predictor of the GLS, explaining 53.9% of its variation. Our study demonstrated that NGT ≥ 155 subjects present functional alterations of myocardial contractile fibres, compared to NGT < 155 subjects, but similar to IGT, and these alterations are correlated with oxidative stress. Moreover, GLS is able to identify early alterations in the contractility of subendocardial longitudinal fibres long before the alteration of EF. This data have a central role in ongoing research on the association between hyperglycaemia at 1-h post load and CV risk.

Transverse dentofacial dimensions according to skeletal maturation

Aim: This study aimed to determine the dentofacial transverse dimensions according to the hand-wrist and cervical vertebrae skeletal maturation stages in order to evaluate the differences between the sexes, to identify the correlations between transverse measurements, and to compare the transverse measurements of individuals of different origins with those of Turkish individuals. Methodology: Transverse measurements were performed using the posteroanterior radiographs of 265 Turkish individuals (150 females, 115 males) at 7–17 years of age. Skeletal maturation was evaluated using hand-wrist radiographs and lateral cephalometric radiographs, and the results were used to categorize the patients into 3 stages of hand-wrist skeletal maturity (prepubertal/pubertal/postpubertal) and 2 stages of cervical vertebrae maturity (prespurt/postspurt). Seven measurements were evaluated. A multivariate linear regression model was used to evaluate the correlations between transverse measurements and the variables of skeletal age and sex. Results: Sex was a significant explanatory factor for all transverse variables. In the postpubertal and postspurt stages, all transverse measurement values were found to be higher in males. Postpubertal term was a significant explanatory factor for maxillary, mandibular, mandibular intermolar, and maxillary intermolar widths, whereas pubertal term was only a significant explanatory factor for maxillary intermolar width. Conclusion: Skeletal age and sex should be taken into account when determining transverse dentofacial measurements. How to cite this article: Sezen Erhamza T, Akan B, Nazik Ünver F, Evli Dalgalı P. Transverse dentofacial dimensions according. Int Dent Res 2021;11(2):99-108. https://doi.org/10.5577/intdentres.2021.vol11.no2.7 Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

Antibody responses to BNT162b2 mRNA COVID-19 vaccine in 2,015 healthcare workers in a single tertiary referral hospital in Japan

We measured antibody responses in 2,015 healthcare workers who were receiving 2 doses of BNT162b2 mRNA vaccine against SARS-CoV-2. The vast majority (99.9%) had either seroconversion or a substantial increase in antibody titer. A multivariate linear regression model identified predictive factors for antibody responses which may have clinical implications.

FACTORS AFFECTING THE CONSULTATION SKILLS OF SOCIAL WORKERS WHEN SUPPORTING AUTISTIC CHILDREN’S FAMILIES: EVIDENCE IN VIETNAM.

The research has identified the factors affecting the level of response to the job requirement of social workers when conducting counseling for families of children with autism in autism care and education centers. To achieve this goal, in this study we surveyed 89 social workers in Hanoi city. The results of the analysis of the multivariate linear regression model have shown that 6 factors have a significant impact on the level of response to the requirement of counseling skills when assisting autistic children's families, including (i) passion for work, (ii) professional knowledge and practical experience, (iii) proactive activeness, (iv) training opportunities to improve qualifications, (v) employment incentives, (vi) job requirements. The results showed that the passion for the job was most appreciated. On this basis, the study offers several meaningful solutions to improve the job response level of social workers when conducting counseling for autistic children's families.

Nickel-Catalyzed Asymmetric Reductive Cross-Coupling of a-Chloroesters with (Hetero)Aryl Iodides

<a></a><a>An asymmetric reductive cross-coupling of alpha-chloroesters and (hetero)aryl iodides is reported. This nickel-catalyzed reaction proceeds with a chiral BiOX ligand under mild conditions, affording alpha-arylesters in good yields and enantioselectivities. The reaction is tolerant of a variety of functional groups, and the resulting products can be converted to pharmaceutically-relevant chiral building blocks</a>. A multivariate linear regression model was developed to quantitatively relate the influence of the alpha-chloroester substrate and ligand on enantioselectivity

Nickel-Catalyzed Asymmetric Reductive Cross-Coupling of a-Chloroesters with (Hetero)Aryl Iodides

<a></a><a>An asymmetric reductive cross-coupling of alpha-chloroesters and (hetero)aryl iodides is reported. This nickel-catalyzed reaction proceeds with a chiral BiOX ligand under mild conditions, affording alpha-arylesters in good yields and enantioselectivities. The reaction is tolerant of a variety of functional groups, and the resulting products can be converted to pharmaceutically-relevant chiral building blocks</a>. A multivariate linear regression model was developed to quantitatively relate the influence of the alpha-chloroester substrate and ligand on enantioselectivity

Bifunctional squaramides with benzyl-like fragments: analysis of CH···π interactions by Multivariate Linear Regression model and Quantum Chemical Topology

We analyzed 15 bifunctional squaramides with benzyl-like fragments in a Michael addition. These substituents are susceptible to form CH⋯π interactions and have distinct properties: electronic features, stereogenic center, as well...