Ketamina, un nuevo agente terapéutico para la depresión

Major depressive disorder affects about one in every 10 people in Mexico and is one of the first 5 causes of disability worldwide. Current treatment options are limited and only act upon some factors associated in its physiopathology. Moreover, the effects on depression are not immediate, which is a great limitation in obtaining a benefit over disability caused by this disorder and impedes a rapid action in the scenario of suicidality. Recently, ketamine (an anesthetic) has shown to have antidepressant properties by acting in the glutamate neurotransmission system (while no other current treatment acts on this level). It offers benefits in depressive symptoms in a matter of hours and has proven to be useful in patients that do not benefit from current therapeutic options. Recently, it has been approved for the treatment of depression. However, there are still many questions about its antidepressant mechanisms of action, safety, side effects, among others. Key words: Depression; antidepressants; ketamine.

Algorithm for screening for depressive and anxiety depressive disorders in women during pregnancy and postpartum period

This article describes the authors developed and tested an algorithm screening diagnosis of depression and anxiety-depressive disorders in women during pregnancy and the postpartum period. Data are presented on the example of screening studies of patients obstetric clinics of the «Institute of pediatrics, obstetrics and gynecology of the National Academy of Medical sciences of Ukraine». Paper presents evidence of the effectiveness and feasibility of use in obstetric and general medical practice developed algorithm for early diagnostics and adequate treatment and rehabilitation depressive and anxiety - depressive disorders in women associated with pregnancy, childbirth and the postpartum period. Key words: depression, anxiety disorders, pregnancy, postpartum, postpartum depression, screening, informed consent, pathopsychological diagnostics.