Attenuation of UV-induced skin photoaging in rats by walnut protein hydrolysates is linked to enhancement of antioxidant capacity, modulation of MAPK/AP-1/TGF-β/Samd signaling pathway, and promotion of type Ⅰ procollagen synthesis

There is growing evidences that prevention of skin photoaging by oral administration of food-derived proteins hydrolysates is intricately linked to its alleviation against oxidative stress through modulation of signaling pathway....

Modulation of Cardiac Metabolism in Heart Failure

Heart failure is associated with altered cardiac metabolism, in part, due to maladaptive mechanisms, in part secondary to comorbidities such as diabetes and ischaemic heart disease. The metabolic derangements taking place in heart failure are not limited to the cardiac myocytes, but extend to skeletal muscles and the vasculature causing changes that contribute to the worsening of exercise capacity. Modulation of cardiac metabolism with partial inhibition of free fatty acid oxidation has been shown to be beneficial in patients with heart failure. At the present, the bulk of evidence for this class of drugs comes from Trimetazidine. Newer compounds partially inhibiting free fatty acid oxidation or facilitating the electron transport on the mitochondrial cristae are in early phase of their clinical development.