Congenital Granular Cell Tumour: Report of a case with review of literature and differential diagnosis.

Congenital Granular Cell Tumour (CGCT) is a rare benign lesion and presents in newborn as fibrous mass arising from the alveolus.The prenatal screening of lesion can help in parent counselling, determining the complications, as larger size lesion may interfere with normal delivery and require caesarean section.

A case of TFE-3-positive non-neoplastic pseudodecidualized endometrium presenting as a cervical mass

Introduction/Objective TFE-3 gene encodes a transcription factor that promotes the expression of genes involved in cell growth and proliferation. Its overactivation can result in oncogenic activity. Although TFE-3 seems to be almost universally expressed in normal tissues, this expression should be at very low levels and strong nuclear expression of TFE-3 is seen almost exclusively in tumors containing or lacking the TFE-3 gene fusion. These include renal cell carcinoma, alveolar soft part sarcomas, epithelioid hemangioendotheliomas, PEComas, granular cell tumour, solid pseudopapillary neoplasm of the pancreas, and ovarian sclerosing stromal tumors. It must be emphasized that only nuclear expression of TFE-3 is of diagnostic value, as non-specific cytoplasmic staining is common. Methods/Case Report A 30-year-old woman with pelvic pain, heavy vaginal bleeding and ureteral stricture on oral contraceptive pill was found to have a cervical mass on exam. Cervical biopsy showed fragments of benign squamous epithelium and polypoid endometrial tissue with atrophic glandular component, stromal pseudodecidualization and abundant mixed inflammation. The stroma was positive for CD10, and negative for P16, desmin, cytokeratin ae1/ae3, CD34, calretinin. There was patchy moderate to strong nuclear staining for TFE-3 (Anti-TFE-3 rabbit monoclonal primary antibody, Cell MarqueTM). No evidence of a neoplastic process was seen, and the overall findings fit with either prolapsed endometrial tissue or endometriosis. TFE-3 by FISH showed no rearrangement of the TFE-3 gene region, ruling out alveolar soft part sarcoma. Results (if a Case Study enter NA) NA Conclusion The Human Protein Atlas, a program mapping all the human proteins in cells and tissues, shows that endometrial stromal and glandular cells can have moderate TFE-3 nuclear expression, using Anti-TFE-3 rabbit polyclonal antibody (Prestige Antibodies ®). In our case, focal strong expression was seen using a monoclonal antibody. In the pathology literature this finding has not been previously reported. Pathologists should be aware of the possibility of strong nuclear expression of TFE-3 in non-neoplastic endometrium to avoid potential misdiagnosis.

Unusual presentation of granular cell tumour of buccal mucosa

Granular cell tumour (GCT) is a rare soft tissue lesion which many consider to have malignant potential of yet unknown aetiopathogenesis. Oral GCT lesions may occur in an area of leucoplakia and are predominantly present on the tongue. This case study highlights an uncommon presentation of this condition located on the buccal mucosa and illustrates the need for meticulous evaluation of suspicious lesions. Due to the malignant risk associated with GCT lesions, it is important to make the correct diagnosis and ensure complete surgical excision for these cases. Ongoing long-term follow-up is also indicated to monitor for recurrence or malignancy.

Granular cell tumour of cecum mimicking a neuroendocrine tumor

Granular cell tumor (GCT) is a benign soft tissue neoplasm generally believed to be of nerve sheath origin. It is most frequently seen in skin, subcutaneous tissue and oral cavity. GCTs are uncommon in gastrointestinal tract (GIT), in which the majority are located in the esophagus. In this article, we report a case of GCT involving cecum in a 22 years lady. She had a sessile polyp in the cecum which was thought to be NET. Typical histomorphology and expression of S-100 on immunohistochemistry confirmed the diagnosis.We have reviewed, the GCTs of cecum reported previously with emphasis on the differential diagnosis. To best of our knowledge, this is only the 3 case of GCT of cecum reported in the Indian literature. Colonic GCTs are extremely uncommon. This is just the third case of GCT of colon in Indian literature. GCTs pose a diagnostic challenge due to lack of symptoms or nonspecific symptoms. Awareness of this entity helps in preventing misdiagnosis as happened in this case and avoiding further unnecessary treatment.

A rare case of cutaneous granular cell tumour

Granular cell tumors are uncommon tumors of uncertain etiology. It accounts for approximately 0.5% of all soft tissue tumors. However, the involvement of skin is rare. Only few cases of cutaneous granular cell tumor is reported till date. Here, we present a case of cutaneous granular cell tumor in a 48 years female patient.

Intracranial meningioma in a pet rat: MRI findings

We herein report the magnetic resonance imaging (MRI) findings in a brain meningioma in a pet rat (Rattus norvegicus domestica). A 1.5-year-old pet rat was referred for depression, ataxia, tremors and bilateral nystagmus; a brain MRI was elected suspecting an intracranial neoplasia. The study was performed with a 0.25 T scanner. The MRI revealed a well-defined oval mass with a heterogeneous appearance, hyperintense in T1 and T2, and with extra-axial localisation and severe brain compression, the mass appeared strongly and diffusely contrast-enhancing. Euthanasia was elected, with the necropsy confirming the presence of a voluminous extra-axial mass. Histologically, a well-differentiated, benign meningotheliomatous meningioma was diagnosed, with the histochemical stains allowing one to exclude a granular cell tumour. To the best of our knowledge, this is the first report of MRI investigations on a pet rat intracranial meningioma.

Congenital granular cell tumour - a case report

Congenital granular cell tumour (epulis) is a rare benign tumour occurring in gingiva of neonates, of unknown histogenesis, predominantly occurring in girls. It can cause feeding and respiratory difficulty. We describe a case of a newborn male baby born with swelling in the gingiva of anterior segment of upper jaw. The lesion was excised, with baby doing well at follow up.