scholarly journals A Comparison of the Efficacy of Dimethyl Sulfoxide (DMSO) and Synovial Fluid in the Prevention of Peritoneal Adhesions: Experimental Rabbit Model

2013 ◽  
Author(s):  
Kemal KILIÇ ◽  
Nergiz KILIÇ ◽  
Sadık YAYLA ◽  
Celal Şahin ERMUTLU ◽  
İsa ÖZAYDIN ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Dimethyl Sulfoxide ◽  
Rabbit Model ◽  
Peritoneal Adhesions

scholarly journals Correlation between synovial fluid calcium containing crystal estimation and varying grades of osteoarthritis created using a rabbit model: Potential diagnostic tool

2020 ◽  
Vol 11 ◽  
pp. S506-S511
Author(s):  
Elizabeth Vinod ◽  
Tephilla Epsibha Jefferson ◽  
Soosai Manickam Amirtham ◽  
Neetu Prince ◽  
Tulasi Geevar ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Diagnostic Tool ◽  
Rabbit Model ◽  
Model Potential

Preservation of Synovial Fluid cellular morphology with dimethyl sulfoxide (DMSO)

Pathology ◽  
2019 ◽  
Vol 51 ◽  
pp. S138
Author(s):  
Katrina Pavic ◽  
Vicki G. McGill ◽  
Neil W. McGill
Keyword(s):  
Synovial Fluid ◽  
Dimethyl Sulfoxide ◽  
Cellular Morphology

scholarly journals Titania-Containing Bone Cement Shows Excellent Osteoconductivity in A Synovial Fluid Environment and Bone-Bonding Strength in Osteoporosis

Materials ◽  
2021 ◽  
Vol 14 (5) ◽  
pp. 1110
Author(s):  
Tomotoshi Kawata ◽  
Koji Goto ◽  
Masashi Imamura ◽  
Yaichiro Okuzu ◽  
Toshiyuki Kawai ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Bone Cement ◽  
Sodium Succinate ◽  
Fluid Pressure ◽  
Rabbit Model ◽  
Femoral Diaphysis ◽  
Methylprednisolone Sodium Succinate ◽  
Fluid Environment ◽  
Total Knee

Titania bone cement (TBC) reportedly has excellent in vivo bioactivity, yet its osteoconductivity in synovial fluid environments and bone-bonding ability in osteoporosis have not previously been investigated. We aimed to compare the osteoconductivity of two types of cement in a synovial fluid environment and determine their bone-bonding ability in osteoporosis. We implanted TBC and commercial polymethylmethacrylate bone cement (PBC) into rabbit femoral condyles and exposed them to synovial fluid pressure. Rabbits were then euthanized at 6, 12, and 26 weeks, and affinity indices were measured to evaluate osteoconductivity. We generated a rabbit model of osteoporosis through bilateral ovariectomy (OVX) and an 8-week treatment with methylprednisolone sodium succinate (PSL). Pre-hardened TBC and PBC were implanted into the femoral diaphysis of the rabbits in the sham control and OVX + PSL groups. Affinity indices were significantly higher for TBC than for PBC at 12 weeks (40.9 ± 16.8% versus 24.5 ± 9.02%) and 26 weeks (40.2 ± 12.7% versus 21.2 ± 14.2%). The interfacial shear strength was significantly higher for TBC than for PBC at 6 weeks (3.69 ± 1.89 N/mm2 versus 1.71 ± 1.23 N/mm2) in the OVX + PSL group. These results indicate that TBC is a promising bioactive bone cement for prosthesis fixation in total knee arthroplasty, especially for osteoporosis patients.

Suppression of Intimal Hyperplasia in a Rabbit Model of Arterial Balloon Injury by Enalaprilat But Not Dimethyl Sulfoxide

1994 ◽  
Vol 8 (2) ◽  
pp. 158-165 ◽  
Author(s):  
Michael M. Law ◽  
Michael D. Colburn ◽  
George E. Hajjar ◽  
Hugh A. Gelabert ◽  
William J. Quiñones-Baldrich ◽  
...  
Keyword(s):  
Dimethyl Sulfoxide ◽  
Intimal Hyperplasia ◽  
Rabbit Model ◽  
Balloon Injury

scholarly journals Effects of adenovirus-mediated knockdown of IRAK4 on synovitis in the osteoarthritis rabbit model

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Muzhe Li ◽  
Huiyun Li ◽  
Xun Ran ◽  
Han Yin ◽  
Xuling Luo ◽  
...  
Keyword(s):  
Synovial Fluid ◽  
Cruciate Ligament ◽  
Interleukin 1 ◽  
Cartilage Damage ◽  
Rabbit Model ◽  
Joint Disease ◽  
Control Group ◽  
Model Group ◽  
Tnf Α ◽  
And Cartilage

Abstract Background The use of interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor as a treatment for the inflammatory joint disease is a promising method. However, its underlying mechanism in osteoarthritis (OA) remains unclear. The purpose of this study is to look into the effects of adenovirus-mediated knockdown of IRAK4 on synovitis in the OA rabbit model. Methods Ad-shIRAK4 was injected two weeks after anterior cruciate ligament resection. Six weeks later, the rabbits were killed. The expression of IRAK4, TNFR-associated factor 6(TRAF6), TGF-activated kinase 1(TAK1), p-IKB kinase (p-IKK), p-nuclear factor kappa-B (p-NFκB), p38, and p-p38 in the synovial membrane was detected by western blot, qRT-PCR, and immunohistochemistry analysis. Immunohistochemistry was to detect the expression of IRAK4 proteins in articular cartilage. H&E staining was to assess the pathological changes of synovium and cartilage. The levels of interleukin (IL)-1β, tumor necrosis factor-α(TNF-α), and MMP-13 in the synovial fluid were measured by ELISA. X-ray and micro-computerized tomography (μCT) scans were used to assess knee joint conditions and microstructure of subchondral bone. Results IRAK4 expression levels in synovial tissues of the OA model group exhibited a significant upward trend. Ad-shIRAK4 significantly reduced IRAK4 mRNA expression in synovium tissues. Notably, Ad-shIRAK4 suppressed the Toll-like receptor/interleukin-1 receptor (TLR/IL-1R) signaling. In addition, in the Ad-shIRAK4 treatment group, we can see less inflammatory cell infiltration and reduced hyperplasia and angiogenesis. The levels of IL-1β, TNF-α, and MMP-13 in the synovial fluid in the OA model group were significantly higher than that in the control group, which were reduced by Ad-shIRAK4 treatment. Finally, Results of HE stains, immunohistochemistry, and μCT showed that Ad-shIRAK4 treatment has a protective effect on cartilage damage. Conclusions IRAK4 is significantly upregulated in the synovium from the osteoarthritis rabbit model. In addition, Ad-shIRAK4 reduced the expression of IRAK4 and suppressed TLR/IL-1R signaling in the synovium from the osteoarthritis rabbit model. Ad-shIRAK4 could alleviate synovitis and cartilage degradation in the osteoarthritis rabbit model, and thus alleviate the symptoms of OA and prevent the progression of OA. Graphical abstract

Changes in the Synovial Fluid Caused by Osmic Acid

1987 ◽  
Vol 16 (1) ◽  
pp. 217-222
Author(s):  
G. Lörincz ◽  
H. A. Isomäki ◽  
J. Martio
Keyword(s):  
Synovial Fluid ◽  
Osmic Acid
Sign in / Sign up

Export Citation Format

Share Document