scholarly journals Molecular biology of vascular malformations of the brain

2001 ◽  
Vol 10 (4) ◽  
pp. 271
Author(s):  
Issam A. Awad ◽  
M Sc ◽  
FACS ◽  
MA(Hon)
2021 ◽  
Vol 22 (11) ◽  
pp. 6141
Author(s):  
Teodora Larisa Timis ◽  
Ioan Alexandru Florian ◽  
Sergiu Susman ◽  
Ioan Stefan Florian

Aneurysms and vascular malformations of the brain represent an important source of intracranial hemorrhage and subsequent mortality and morbidity. We are only beginning to discern the involvement of microglia, the resident immune cell of the central nervous system, in these pathologies and their outcomes. Recent evidence suggests that activated proinflammatory microglia are implicated in the expansion of brain injury following subarachnoid hemorrhage (SAH) in both the acute and chronic phases, being also a main actor in vasospasm, considerably the most severe complication of SAH. On the other hand, anti-inflammatory microglia may be involved in the resolution of cerebral injury and hemorrhage. These immune cells have also been observed in high numbers in brain arteriovenous malformations (bAVM) and cerebral cavernomas (CCM), although their roles in these lesions are currently incompletely ascertained. The following review aims to shed a light on the most significant findings related to microglia and their roles in intracranial aneurysms and vascular malformations, as well as possibly establish the course for future research.


2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Gazanfar Rahmathulla ◽  
Steven A. Toms ◽  
Robert J. Weil

Metastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancers. Various crucial interactions between the brain environment and tumor cells take place during the development of the cancer at its new location. The rapid expansion in molecular biology and genetics has advanced our knowledge of the underlying mechanisms involved, from invasion to final colonization of new organ tissues. Understanding the various events occurring at each stage should enable targeted drug delivery and individualized treatments for patients, with better outcomes and fewer side effects. This paper summarizes the principal molecular and genetic mechanisms that underlie the development of brain metastasis (BrM).


2019 ◽  
Vol 1 (1) ◽  
pp. 1-16
Author(s):  
Paul Elliott

“I don’t believe that linguistics and psychoanalysis offer a great deal to the cinema. On the contrary, the biology of the brain – molecular biology – does.” Gilles DeleuzeModels of the brain are inextricably linked to the surrounding cultural episteme: whether it is viewed as a complex clockwork device, a computer, a self-regulating network or even a cinema screen, our understanding of neurophysiology has always relied on discourses and images taken from other fields. In turn, however, our knowledge of cerebral processes (such as sight for instance) has always, inevitably, affected the way that we approach artworks, literary texts and cultural artefacts.Based on this, this paper looks at how recent neuroscientific research on vision and cognition can help us better understand the processes inherent in film theory. Focussing mainly on the recently discovered concept of the mirror neuron but also citing synaesthesia and limbic perceptual processing, I suggest that neuroscience can provide us with a fertile new ground for thinking about areas such as spectatorship and the facilitation of emotional affect, it can also offer us alternatives to monolithic ideas like the Gaze and the patriarchal nature of visual pleasure.Prompted perhaps by a shift in scopic thinking, some recent neuroscientific research has even mirrored film and cultural theory by foregrounding notions such embodiment, cross-model perception and mimesis, adding to the dialogic relationship that exists between these two disciplines. This paper then is not only concerned with how different fields communicate but with how each can provide models, metaphors and frameworks for the other.


2021 ◽  
Author(s):  
◽  
C. J. González Leal

NeuroPort is a low cost customized biodevice for minimal invasion surgeries designed within Servicio Neurocirugía UANL and Departamento de Ingeniería Biomédica; and manufactured by stereolithography, a high- resolution 3D printing method. This biodevice provides a channel of approach for subcortical and intraventricular cerebral surgical procedures with an intended use in the treatment of diseases such as brain tumors, anomalies or vascular malformations, parenchymal hematomas, among others. It has a design that minimizes tissue damage by displacing the tissues of the brain during the advance toward the desired abnormality; in addition to its integration with neuronavigational equipment and its own lighting system. All these features designed to make the surgical procedure faster and safer for the patient, facilitating the work of the neurosurgeon.


2000 ◽  
Vol 75 (1) ◽  
pp. 81-81
Author(s):  
Eric E. Turner
Keyword(s):  

1996 ◽  
Vol 7 (2) ◽  
pp. 201-214 ◽  
Author(s):  
Lucia Zamorano ◽  
Miguel Lis-Planells ◽  
Zhaowei Jiang ◽  
Lutz Nolte ◽  
A. Majeed Kadi ◽  
...  

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