Shear Wave Elastography for Liver Stiffness Measurement in Clinical Sonographic Examinations

2014 ◽  
Vol 33 (3) ◽  
pp. 437-447 ◽  
Author(s):  
Jeong Hee Yoon ◽  
Jeong Min Lee ◽  
Joon Koo Han ◽  
Byung Ihn Cho
Keyword(s):  
Shear Wave ◽  
Liver Stiffness ◽  
Shear Wave Elastography ◽  
Liver Stiffness Measurement ◽  
Stiffness Measurement

scholarly journals Two-dimensional shear wave elastography and ultrasound-guided attenuation parameter for progressive non-alcoholic steatohepatitis

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249493
Author(s):  
Hidekatsu Kuroda ◽  
Yudai Fujiwara ◽  
Tamami Abe ◽  
Tomoaki Nagasawa ◽  
Takuma Oguri ◽  
...  
Keyword(s):  
Shear Wave ◽  
Attenuation Coefficient ◽  
Liver Stiffness ◽  
Shear Wave Elastography ◽  
Two Dimensional ◽  
Ultrasound Guided ◽  
Liver Stiffness Measurement ◽  
Stiffness Measurement ◽  
Attenuation Parameter ◽  
Alcoholic Steatohepatitis

Background and aims We investigated the usefulness of combining two-dimensional shear wave elastography and the ultrasound-guided attenuation parameter for assessing the risk of progressive non-alcoholic steatohepatitis, defined as non-alcoholic steatohepatitis with a non-alcoholic fatty liver disease activity score of ≥4 and a fibrosis stage of ≥2. Methods This prospective study included 202 patients with non-alcoholic fatty liver disease who underwent two-dimensional shear wave elastography, ultrasound-guided attenuation parameter, vibration-controlled transient elastography, the controlled attenuation parameter, and liver biopsy on the same day. Patients were grouped according to liver stiffness measurement using two-dimensional shear wave elastography and the attenuation coefficient, assessed using the ultrasound-guided attenuation parameter: A, low liver stiffness measurement/low attenuation coefficient; B, low liver stiffness measurement/high attenuation coefficient; C, high liver stiffness measurement/low attenuation coefficient; and D, high liver stiffness measurement/high attenuation coefficient. Results Two-dimensional shear wave elastography and vibration-controlled transient elastography had equivalent diagnostic performance for fibrosis. The areas under the curve of the ultrasound-guided attenuation parameter for identifying steatosis grades ≥S1, ≥S2, and S3 were 0.89, 0.91, and 0.92, respectively, which were significantly better than those of the controlled attenuation parameter (P<0.05). The percentages of progressive non-alcoholic steatohepatitis in Groups A, B, C, and D were 0.0%, 7.7%, 35.7%, and 50.0%, respectively (P<0.001). The prediction model was established as logit (p) = 0.5414 × liver stiffness measurement (kPa) + 7.791 × attenuation coefficient (dB/cm/MHz)—8.401, with area under the receiver operating characteristic curve, sensitivity, and specificity values of 0.832, 80.9%, and 74.6%, respectively; there was no significant difference from the FibroScan-aspartate aminotransferase score. Conclusion Combined assessment by two-dimensional shear wave elastography and the ultrasound-guided attenuation parameter is useful for risk stratification of progressive non-alcoholic steatohepatitis and may be convenient for evaluating the necessity of specialist referral and liver biopsy.

scholarly journals AB0418 SHEAR WAVE ELASTOGRAPHY FOR THE ASSESSMENT OF LIVER FIBROSIS IN PATIENTS WITH SYSTEMIC SCLEROSIS AND SYSTEMIC SCLEROSIS/PRIMARY BILIARY CHOLANGITIS OVERLAP COMPARED TO PRIMARY BILIARY CHOLANGITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1237.1-1237
Author(s):  
V. Korendovych ◽  
J. G. Rademacher ◽  
G. Petzold ◽  
P. Korsten
Keyword(s):  
Systemic Sclerosis ◽  
Liver Fibrosis ◽  
Hepatic Steatosis ◽  
Shear Wave ◽  
Liver Stiffness ◽  
Shear Wave Elastography ◽  
Primary Biliary Cholangitis ◽  
Clinical Use ◽  
Liver Stiffness Measurement ◽  
Stiffness Measurement

Background:Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and skin as well as organ fibrosis. The lungs, skin, and gastrointestinal care frequently affected. Primary biliary cholangitis (PBC) is an autoimmune disease of the liver associated with potential progression to liver fibrosis. More recently, these two disorders have been described as an overlapping entity, especially in patients with limited, anti-centromere (CENP-B) positive SSc (1). Here, we report the first results of a pilot study of shear wave elastography (SWE) in patients with SSc and SSc/PBC compared to PBC patients.Objectives:To assess liver stiffness in patients with SSc, SSC/PBC overlap, and PBC with shear wave elastography.Methods:We analyzed a sample of 10 SSc to 11 PBC patients. In all patients, a baseline US examination of the liver and liver stiffness measurement by 2D SWE were performed using a GE logiq E10 ultrasound machine. Normal values for SWE in healthy people have recently been published (2). Liver stiffness measurement was performed according to the recommendations of the manufacturer and the recommendations of the current “EFSUMB Guideline and Recommendation on the Clinical Use of Liver Elastography” (3). In addition, age, body mass index (BMI), and antibody profiles were assessed.Results:Of 8 SSc patients without PBC, 6 were anti-CENPB pos., 1 had Scl70, and 1 Pm/Scl antibody. Median age was 59.5 (47-71). Median BMI was 23.1 (19.6-25). 1 patient had SSc/PBC overlap, 1 had hepatic steatosis. 1 was positive for CENP-B/AMA-M2 antibodies, the other patient was Scl70 positive. Median age of these 2 patients was 55.5 (55-56), BMI was 23.86 (20.9-26.8). 11 patients with PBC were positive for AMA-M2 antibodies, median age was 58 (41-78) years, BMI was 27.8 (15.8-50.3). The differences were not statistically different. Liver stiffness is expressed in kPa. Measurements had an interquartile range/median ratio <30%, indicating sufficient quality of the measurement. Liver stiffness was higher in patients with SSc/PBC overlap/hepatic steatosis (9.4±0.18, **p=0.0133) and PBC alone (7.359±2.51, **p=0.0163) compared to SSc alone (4.526±0.89 kPa). The results indicate that PBC is the main driver of liver stiffness in patients with SSc, and SSc alone may not necessarily lead to an increased liver stiffness (figure 1).Figure 1.Conclusion:Our results indicate that SWE is a useful tool in for the non-invasive assessment of liver stiffness in SSc and SSc/PBC overlap. We will further increase the sample size, especially of patients with SSc/PBC overlap. Of note, other liver diseases, such as hepatic steatosis, have to be kept in mind when SWE is performed as they may contribute to liver stiffness.References:[1]Lepri G, Randone SB, Cerinic MM, Allanore Y. Systemic sclerosis and primary biliary cholangitis: An overlapping entity?: Journal of Scleroderma and Related Disorders [Internet]. 2018 Oct 25 [cited 2020 Jun 17]; Available from: https://journals.sagepub.com/doi/10.1177/2397198318802763[2]Petzold G, Hofer J, Ellenrieder V, Neesse A, Kunsch S. Liver Stiffness Measured by 2-Dimensional Shear Wave Elastography: Prospective Evaluation of Healthy Volunteers and Patients With Liver Cirrhosis. J Ultrasound Med. 2019 Jul;38(7):1769–77.[3]Dietrich CF, Bamber J, Berzigotti A, Bota S, Cantisani V, Castera L, et al. EFSUMB Guidelines and Recommendations on the Clinical Use of Liver Ultrasound Elastography, Update 2017 (Long Version). Ultraschall Med. 2017 Aug;38(4):e48.Disclosure of Interests:Viktor Korendovych: None declared, Jan-Gerd Rademacher: None declared, Golo Petzold: None declared, PETER KORSTEN Speakers bureau: Abbvie, Pfizer, Boehringer-Ingelheim, Novartis, Chuigai, Sanofi, GSK, all unrelated., Consultant of: Abbvie, Pfizer, Boehringer-Ingelheim, Novartis, Chuigai, Sanofi, GSK, Gilead, Lilly, all unrelated., Grant/research support from: GSK, unrelated to this study.

scholarly journals Measurement of Liver Stiffness Using Shear Wave Elastography in a Rat Model: Factors Impacting Stiffness Measurement with Multiple- and Single-Tracking-Location Techniques

2017 ◽  
Vol 43 (11) ◽  
pp. 2629-2639 ◽  
Author(s):  
Jonathan H. Langdon ◽  
Etana Elegbe ◽  
Raul S. Gonzalez ◽  
Laurentius Osapoetra ◽  
Tristan Ford ◽  
...  
Keyword(s):  
Shear Wave ◽  
Rat Model ◽  
Liver Stiffness ◽  
Shear Wave Elastography ◽  
Stiffness Measurement

Assessment of impact factors on shear wave based liver stiffness measurement

2013 ◽  
Vol 82 (2) ◽  
pp. 335-341 ◽  
Author(s):  
Wenwu Ling ◽  
Qiang Lu ◽  
Jierong Quan ◽  
Lin Ma ◽  
Yan Luo
Keyword(s):  
Shear Wave ◽  
Liver Stiffness ◽  
Impact Factors ◽  
Liver Stiffness Measurement ◽  
Stiffness Measurement
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