scholarly journals Evaluation of bacteriophages for prevention and treatment of diarrhea due to experimental enterotoxigenic Escherichia coli K88 infection of weaned piglets

2011 ◽  
Vol 34 (4) ◽  
pp. 341-352 ◽  
Author(s):  
Sung-Jae Kim ◽  
Jin-Dong Kim ◽  
Si-Yong Yang ◽  
Nam-Hee Kim ◽  
Chang-Hee Lee ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Enterotoxigenic Escherichia Coli ◽  
Weaned Piglets ◽  
Prevention And Treatment

Small intestinal segment perfusion test in piglets: future applications in studying probiotics-gut crosstalk in infectious diarrhoea?

2010 ◽  
Vol 1 (4) ◽  
pp. 439-445 ◽  
Author(s):  
J. van der Meulen ◽  
M. Hulst ◽  
M. Smits ◽  
T. Schuurman
Keyword(s):  
Physiological Response ◽  
Enterotoxigenic Escherichia Coli ◽  
Weaned Piglets ◽  
Infectious Diarrhoea ◽  
Secretory Diarrhoea ◽  
Prevention And Treatment ◽  
Small Intestinal ◽  
Traveller’S Diarrhoea ◽  
Intestinal Compartments

Worldwide infectious diarrhoea, mainly caused by rotavirus and enterotoxigenic Escherichia coli (ETEC), accounts for a large part of deaths in children. ETEC is also the main cause of traveller's diarrhoea. Probiotics are promising for prevention and treatment of diarrhoea, but there is insufficient evidence to support the use of any specific probiotic or probiotics in general. Because of the sensitivity of suckling and weaned piglets for ETEC, piglets are a good model for infectious diarrhoea in infants and traveller's diarrhoea. Just as in human the efficacy of probiotics in diminishing diarrhoea and improving growth in suckling and weaned piglets is not uniform. A piglet model of infectious diarrhoea provides access to intestinal compartments that are not easily accessible in infants. In an in situ piglet model of secretory diarrhoea, the functional physiological response to ETEC and the concomitant host genome response to ETEC and probiotics may be tested. This will provide new insights in the complex crosstalk between ETEC, probiotics and the gut in the future.

The effect of enterotoxigenic Escherichia coli F4ab,ac on early-weaned piglets: A gene expression study

2013 ◽  
Vol 152 (1-2) ◽  
pp. 87-92 ◽  
Author(s):  
M. Schroyen ◽  
B.M. Goddeeris ◽  
A. Stinckens ◽  
R. Verhelst ◽  
S. Janssens ◽  
...  
Keyword(s):  
Gene Expression ◽  
Escherichia Coli ◽  
Enterotoxigenic Escherichia Coli ◽  
Gene Expression Study ◽  
Weaned Piglets ◽  
Expression Study

PSX-A-20 Late-Breaking: Potential prebiotic effect of canola meal non-starch polysaccharide hydrolysis products in weaned piglets challenged with enterotoxigenic Escherichia coli F4

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 369-370
Author(s):  
Xiaoxiao Zhang ◽  
Bonjin Koo ◽  
Debora Holanda ◽  
Martin Nyachoti ◽  
Jinyoung Lee
Keyword(s):  
Escherichia Coli ◽  
Negative Control ◽  
Enterotoxigenic Escherichia Coli ◽  
Canola Meal ◽  
Experimental Unit ◽  
Adaptation Period ◽  
Weaned Piglets ◽  
Gene Expressions ◽  
Hydrolysis Products ◽  
Polysaccharide Hydrolysis

Abstract Enzymatically derived non-starch polysaccharide hydrolysis products (HP) may modulate enteric health outcomes in piglets. Thus, responses of weaned piglets to an oral challenge with enterotoxigenic Escherichia coli F4 (ETEC) when fed diets containing canola meal (CM) HP were investigated. The HP were obtained by incubating CM with a multi-carbohydrase (MC) blend. Thirty-five weaned piglets (8.08 ± 0.34 Kg BW) were individually assigned in a completely randomized design to 1 of 5 treatments: UCC (unchallenged control), NC (negative control challenged with ETEC), PC (NC + 0.1% AGP), HP1 (NC + 0.25% HP), HP2 (NC + 0.5% HP). After a seven-day adaptation period, piglets in the UCC group received 5 ml of PBS, whereas those in all other groups were orally challenged with 5 ml (5 × 106 CFU/mL) of ETEC F4. On d 14 all piglets were euthanized for tissue sampling. Data were analyzed using the PROC MIXED procedure of SAS 9.4, with the individual pig as the experimental unit. During the post-challenge period, piglets fed NC diet had lower (P < 0.05) G: F than those fed the PC, whereas the G: F was higher (P < 0.05) for piglets fed the HP-containing diets than that of piglets fed the NC diet. Piglets fed diets containing HP showed lower (P < 0.05) jejunum pH and fecal scores than piglets fed the NC diet. For gene expressions, the HP groups showed a greater level of toll like receptor 2 (TLR2) compared with NC group (P < 0.05). For the HP groups, HP1 had a higher (P < 0.05) level of TLR2 than HP2 treatment. Feeding HP resulted in lower relative abundance of Bifidobacterium in the colon of piglets compared with feeding with NC (P < 0.05). In conclusion, piglets fed diets with CM HP exhibited less severe ETEC-enteritis and had similar effects with AGP.

F4 (K88) fimbrial adhesin FaeG expressed in alfalfa reduces F4+ enterotoxigenic Escherichia coli excretion in weaned piglets

Vaccine ◽  
2006 ◽  
Vol 24 (13) ◽  
pp. 2387-2394 ◽  
Author(s):  
J.J. Joensuu ◽  
F. Verdonck ◽  
A. Ehrström ◽  
M. Peltola ◽  
H. Siljander-Rasi ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Enterotoxigenic Escherichia Coli ◽  
Weaned Piglets ◽  
Fimbrial Adhesin
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