scholarly journals Gabapentin for Post-Hospitalization Alcohol Relapse Prevention; Should Gabapentin Be Considered for FDA Approval in the Treatment of Alcohol Use Disorder?: A Case Presentation and Literature Review

Cureus ◽  
2020 ◽  
Author(s):  
Ian H Rutkofsky ◽  
Kristy A Fisher ◽  
Clara L Alvarez Villalba ◽  
Samuel Neuhut
Keyword(s):  
Alcohol Use ◽  
Literature Review ◽  
Relapse Prevention ◽  
Alcohol Use Disorder ◽  
Case Presentation ◽  
Alcohol Relapse ◽  
Fda Approval

scholarly journals Does a Supplement Cocktail a Day Keep the Doctor Away? An Unusual Case of Alcohol Induced Diabetes Mellitus: A Case Report and Review of Literature

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A379-A380
Author(s):  
Kaley N Breault ◽  
Brittney H Arakaki ◽  
Peminda K Cabandugama ◽  
Jordan M Rowe
Keyword(s):  
Diabetes Mellitus ◽  
Alcohol Use ◽  
Literature Review ◽  
Glucose Control ◽  
Alcohol Use Disorder ◽  
Chromium Picolinate ◽  
Insulin Regimen ◽  
C Peptide ◽  
Insulin Dependent ◽  
Pancreatic Dysfunction

Abstract Background: Currently there are no evidence-based medical recommendations to support the use of supplements in type 1 diabetes mellitus (DM), although there is some data that supports glucose lowering in type 2 DM with supplements such as cinnamon. Additionally, there is no evidence regarding the use of supplements in insulin-dependent DM secondary to pancreatic dysfunction from alcohol use disorder. Despite lack of clear evidence, it is estimated that more than 65% of Americans with DM use at least one dietary supplement for perceived health benefits. (1)Clinical Case: A 58-year old male presented with insulin-dependent DM secondary to pancreatic dysfunction from alcohol use disorder. Initial labs were significant for a low C-peptide of 0.13 ng/mL (0.80–3.85 ng/mL), A1c -9.4%, and blood glucoses ranging from 160–300 mg/dL. Patient’s DM regimen consisted of glargine 40 units nightly and aspart 12 units three times a day with meals. On a subsequent visit two months later, the patient stated that he had begun taking numerous supplements in hopes that these would improve his overall medical status. Supplements included Blood Boost Formula, Ultra K2 with MK-7, Chromium Picolinate, Male Enhancement, Super C Immune Complex, Nugenix Total-T, Niacinamide, Omega Q Plus Max, Cortisol Hormone Balancer, and Vitamin D3. Simultaneously, the patient self-discontinued all his maintenance medications except for his aforementioned insulin regimen due to the fear of negatively impacting his pancreas. Unexpectedly, his blood glucoses improved to a range of 90–150 mg/dL after being on these supplements without increasing his insulin dose. Upon literature review, three ingredients showed the most evidence for the possible explanation for his improvement in glucose control: L-arginine, nettle extract, and biotin with chromium. Conclusion: Literature review of in vivo and randomized, placebo-controlled studies demonstrated mechanisms of action for L-arginine, nettle extract, and biotin with chromium that indicate their potential role in lowering blood glucoses and increasing C-peptide levels in insulin-dependent DM secondary to pancreatic dysfunction from alcohol use disorder. Further investigations include exploring long-term impact on pancreatic function, glucose control, and insulin resistance. Reference: (1) Garrow, D., Egede, L. Association Between Complementary and Alternative Medicine Use, Preventive Care Practices, and Use of Conventional Medical Services Among Adults with Diabetes. Diabetes Care 2006 Jan; 29(1): 15–19.

scholarly journals Do Alcohol Relapse Episodes During Treatment Predict Long-Term Outcomes? Investigating the Validity of Existing Definitions of Alcohol Use Disorder Relapse

2016 ◽  
Vol 40 (10) ◽  
pp. 2180-2189 ◽  
Author(s):  
Stephen A. Maisto ◽  
Corey R. Roos ◽  
Kevin A. Hallgren ◽  
Dezarie Moskal ◽  
Adam D. Wilson ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Long Term Outcomes ◽  
Alcohol Relapse

scholarly journals Predicting the Risk of Alcohol Use Disorder Using Machine Learning: A Systematic Literature Review

IEEE Access ◽  
2021 ◽  
pp. 1-1
Author(s):  
Ali Ebrahimi ◽  
Uffe Kock Wiil ◽  
Thomas Schmidt ◽  
Amin Naemi ◽  
Anette Sxgaard Nielsen ◽  
...  
Keyword(s):  
Machine Learning ◽  
Alcohol Use ◽  
Literature Review ◽  
Systematic Literature Review ◽  
Alcohol Use Disorder

The recognition and management of protracted alcohol withdrawal may improve and modulate the pharmacological treatment of alcohol use disorder

2020 ◽  
Vol 34 (11) ◽  
pp. 1171-1175
Author(s):  
Fabio Caputo ◽  
Mauro Cibin ◽  
Antonella Loche ◽  
Roberto De Giorgio ◽  
Giorgio Zoli
Keyword(s):  
Alcohol Use ◽  
Alcohol Withdrawal ◽  
Alcohol Use Disorder ◽  
Alcohol Withdrawal Syndrome ◽  
Signs And Symptoms ◽  
Pharmacological Therapy ◽  
Acute Stage ◽  
Gamma Aminobutyric Acid ◽  
Alcohol Relapse ◽  
Time Frames

About 50% of persons with an alcohol use disorder may have symptoms of alcohol withdrawal syndrome (AWS) when they reduce or discontinue their alcohol consumption. Protracted alcohol withdrawal (PAW), an underestimated and not yet clearly defined clinical condition that follows the acute stage of AWS, is characterized by the presence of substance-specific signs and symptoms (i.e. anxiety, irritability, mood instability, insomnia, craving) common to acute AWS, but persisting beyond the generally expected acute AWS time frames. Considering that PAW symptoms are mainly related to the neuro-adaptive changes of gamma-aminobutyric acid (GABA) and N-methyl-d-aspartate (NMDA) systems, naltrexone, nalmefene, and disulfiram may not be able to suppress the symptoms of PAW. After treatment of the acute phase of AWS, a more specifically pharmacological therapy able to suppress PAW symptoms could perhaps be used earlier and may be more helpful in preventing the risk of alcohol relapse, which remains higher during the first months of treatment. In light of this, medications acting on GABA and NMDA neurotransmitter systems to counterbalance the up-regulation of NMDA and the down-regulation of GABA could be employed in combination and started as soon as possible.

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