scholarly journals Two False Negative Test Results in a Symptomatic Patient with a Confirmed Case of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Suspected Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis (SJS/TEN)

Cureus ◽  
2020 ◽  
Author(s):  
Tomer Lagziel ◽  
Luis Quiroga ◽  
Margarita Ramos ◽  
Charles S Hultman ◽  
Mohammed Asif
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Toxic Epidermal Necrolysis ◽  
False Negative ◽  
Symptomatic Patient ◽  
Stevens Johnson Syndrome ◽  
Test Results ◽  
Negative Test ◽  
Johnson Syndrome ◽  
False Negative Test

Incidence and Recovery of Salmonellae and Other Bacteria from Commercially Processed Poultry Carcasses at Selected Pre- and Post-Evisceration Steps

1989 ◽  
Vol 52 (2) ◽  
pp. 88-91 ◽  
Author(s):  
H. S. LILLARD
Keyword(s):  
False Negative ◽  
Aerobic Bacteria ◽  
Processing Plant ◽  
Test Results ◽  
Negative Test ◽  
Commercial Plant ◽  
Sampling Points ◽  
Processing Line ◽  
False Negative Test ◽  
Progressive Sampling

This study was undertaken to determine whether bacteria are already attached to poultry skin when birds arrive at the processing plant. Multiple rinses were performed on breast skin and whole carcasses taken from five processing points in a commercial plant: Before scalding, after scalding, after picking, after the final washer, and from the exit end of the chiller. Aerobic bacteria and Enterobacteriaceae were recovered from carcasses in up to 40 consecutive whole carcass rinses with a difference of only about one log for Enterobacteriaceae, and 1 to 2 logs for aerobes from the first to the last rinse of carcasses taken from the beginning and the end of the processing line. Data from rinses prior to scalding indicated that bacteria were firmly attached to poultry carcasses when they first arrived in the plant. Not all bacteria were removed during processing; however, there were fewer aerobes and Enterobacteriaceae at progressive sampling points. Attached salmonellae were not always recovered in the first whole carcass rinse, but were sometimes recovered in 3rd, 5th, and 10th rinses. These data show that a single whole carcass rinse can result in false negative test results for salmonellae. Because of the small number of positive samples in this study, the probability of recovering salmonellae with a single whole carcass rinse could not be estimated accurately.

scholarly journals False-negative test results to non-agglutinating (incomplete) antibodies.

1982 ◽  
Vol 58 (4) ◽  
pp. 275-276
Author(s):  
E de Klerk ◽  
C A Sharp ◽  
C Geffen ◽  
R Anderson
Keyword(s):  
False Negative ◽  
Test Results ◽  
Negative Test ◽  
False Negative Test

scholarly journals COVID-19 Testing: Challenges, Limitations and Suggestions for Improvement

2020 ◽  
Author(s):  
Emily Hu
Keyword(s):  
False Negative ◽  
Diagnostic Methods ◽  
Test Results ◽  
Successful Management ◽  
Negative Test ◽  
Reliable Methods ◽  
False Negative Test

Reliable methods to confirm the diagnosis of COVID-19 are essential to the successful management and containment of the virus. Current diagnostic options are limited in type, supply, and reliability. This article explores the controversial unreliability of existing diagnostic methods and maintains that more reliable diagnostic methods, combinations, and sequencing are necessary to effectively assist in reducing the occurrence of discharge of the patient on false negative test results. This reduction would in effect reduce transmission of the disease.

Risk factors for false positive and for false negative test results in screening with fecal occult blood testing

2013 ◽  
Vol 133 (10) ◽  
pp. 2408-2414 ◽  
Author(s):  
Inge Stegeman ◽  
Thomas R. de Wijkerslooth ◽  
Esther M. Stoop ◽  
Monique van Leerdam ◽  
M. van Ballegooijen ◽  
...  
Keyword(s):  
Risk Factors ◽  
False Positive ◽  
False Negative ◽  
Occult Blood ◽  
Fecal Occult Blood Testing ◽  
Fecal Occult Blood ◽  
Test Results ◽  
Negative Test ◽  
Fecal Occult ◽  
False Negative Test

scholarly journals Informed choice on Pap smear still limited by lack of knowledge on the meaning of false-positive or false-negative test results

2011 ◽  
Vol 85 (2) ◽  
pp. 214-218 ◽  
Author(s):  
Ida J. Korfage ◽  
Marjolein van Ballegooijen ◽  
Brendy Wauben ◽  
J. Dik F. Habbema ◽  
Marie-Louise Essink-Bot
Keyword(s):  
False Positive ◽  
Pap Smear ◽  
False Negative ◽  
Informed Choice ◽  
Test Results ◽  
Negative Test ◽  
False Negative Test ◽  
Lack Of Knowledge

RE: “PROBABILITY OF INTRODUCING DISEASES BECAUSE OF FALSE NEGATIVE TEST RESULTS”

1991 ◽  
Vol 133 (3) ◽  
pp. 321-321 ◽  
Author(s):  
Margaret A. Thorburn ◽  
John J. McDermott ◽  
S. Wayne Martin
Keyword(s):  
False Negative ◽  
Test Results ◽  
Negative Test ◽  
False Negative Test

scholarly journals Characteristics of Inpatients with False-Negative SARS-CoV-2 PCR Test Results

2021 ◽  
Vol 1 (S1) ◽  
pp. s56-s56
Author(s):  
Antigone Kraft ◽  
Jessica Ridgway ◽  
Erica Mackenzie ◽  
Aniruddha Hazra ◽  
Maggie Collison ◽  
...  
Keyword(s):  
False Negative ◽  
Inpatient Setting ◽  
Test Results ◽  
Repeated Testing ◽  
Radiographic Findings ◽  
Negative Test ◽  
Tomography Scan ◽  
Unnecessary Testing ◽  
Pcr Test ◽  
False Negative Test

Background: At our institution, the concern for false-negative nasopharyngeal testing for SARS-CoV-2 at the onset of illness led to a general policy of retesting inpatients at 48 hours. For such patients, 2 negative SARS-CoV-2 PCR test results were required prior to discontinuation of COVID-19 control precautions. To assess the utility of routine repeat testing We analyzed patients presenting to our hospital who initially tested negative for SARS-CoV-2 but were found to be positive on repeated testing. Methods: All inpatients with symptoms concerning for COVID-19 were tested via nasopharyngeal sample for SARS-CoV-2 by PCR on admission. Patients with continued symptoms and no alternative diagnosis were retested 48 hours later. Testing was performed using either the Roche cobas SARS-CoV-2 RT-PCR assay or the Cepheid Xpert Xpress SARS-CoV-2 test. Between March 17, 2020, and May 10, 2020, we retrospectively analyzed data from patients with false-negative SARS-CoV-2 PCR test results who were subsequently confirmed positive 48 hours later. We evaluated demographic information, days since symptom onset, symptomatology, chest imaging, vital sign trends, and the overall clinical course of each patient. Results: During the study period, 14,683 tests were performed, almost half (n = 7,124) were performed through the ED and in the inpatient setting. Of 2,283 patients who tested positive for SARS-CoV-2, only 19 (0.01%) initially tested negative. Patients with initial false-negative test results presented with symptoms that ranged from fever and dyspnea to fatigue and vomiting. Notably, few patients presented “early” in their disease (median, 6 days; range, 0–10 days). However, patients with initial false-negative PCR test results did seem to have consistent imaging findings, specifically bilateral bibasilar ground glass opacities on chest radiograph or computed tomography scan. Conclusions: Among inpatients with COVID-19, we found a very low rate of initial false-negative SARS-CoV-2 PCR test results, which were not consistently related to premature testing. We also identified common radiographic findings among patients with initially false-negative test results, which could be useful in triaging patients who may merit retesting. Based on these data, we revised our existing clearance criteria to allow for single-test removal of COVID-19 precautions. Evaluating subsequent reduction in unnecessary testing is difficult given changing community prevalence, increased census, and increased opening to elective procedures. However, given the significant percentage of ED and inpatient testing, removal of repeated testing has likely resulted in a reduction of several thousand unnecessary COVID-19 tests monthly.Funding: NoDisclosures: None

scholarly journals Qualitative Variation among Commercial Immunoassays for Detection of Measles-Specific IgG

2020 ◽  
Vol 58 (6) ◽  
Author(s):  
Donald R. Latner ◽  
Sun B. Sowers ◽  
Kiana Anthony ◽  
Heather Colley ◽  
Christine Badeau ◽  
...  
Keyword(s):  
Neutralizing Antibodies ◽  
Measles Virus ◽  
False Negative ◽  
Test Results ◽  
Serum Samples ◽  
Gold Standard Method ◽  
Negative Test ◽  
Specific Igg ◽  
False Negative Test

ABSTRACT Measurement of measles virus-specific IgG is used to assess presumptive evidence of immunity among immunocompetent individuals with uncertain immune or vaccination status. False-negative test results may lead to unnecessary quarantine and exclusion from activities such as employment, education, and travel or result in unnecessary revaccination. In contrast, false-positive results may fail to identify susceptible individuals and promote spread of disease by those who are exposed and unprotected. To better understand the performance characteristics of tests to detect measles IgG, we compared five widely used, commercially available measles IgG test platforms using a set of 223 well-characterized serum samples. Measles virus neutralizing antibodies were also measured by in vitro plaque reduction neutralization, the gold standard method, and compared to IgG test results. Discrepant results were observed for samples in the low-positive ranges of the most sensitive tests, but there was good agreement across platforms for IgG-negative sera and for samples with intermediate to high levels of IgG. False-negative test results occurred in approximately 11% of sera, which had low levels of neutralizing antibody.

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