Risk factors for false positive and for false negative test results in screening with fecal occult blood testing

2013 ◽  
Vol 133 (10) ◽  
pp. 2408-2414 ◽  
Author(s):  
Inge Stegeman ◽  
Thomas R. de Wijkerslooth ◽  
Esther M. Stoop ◽  
Monique van Leerdam ◽  
M. van Ballegooijen ◽  
...  
Keyword(s):  
Risk Factors ◽  
False Positive ◽  
False Negative ◽  
Occult Blood ◽  
Fecal Occult Blood Testing ◽  
Fecal Occult Blood ◽  
Test Results ◽  
Negative Test ◽  
Fecal Occult ◽  
False Negative Test

Rightside colorectal cancers are likely to give false negative test of fecal occult blood on the basis of screening total colonoscopy

2001 ◽  
Vol 120 (5) ◽  
pp. A66 ◽  
Author(s):  
Yutaka Yamaji ◽  
Makoto Okamoto ◽  
Haruhiko Yoshida ◽  
Takao Kawabe ◽  
Yasushi Shiratori ◽  
...  
Keyword(s):  
False Negative ◽  
Occult Blood ◽  
Colorectal Cancers ◽  
Fecal Occult Blood ◽  
Total Colonoscopy ◽  
Negative Test ◽  
Fecal Occult ◽  
False Negative Test

Pilot study of the effect of gastrointestinal diets on fecal occult blood testing in cats

2019 ◽  
Vol 22 (7) ◽  
pp. 656-663
Author(s):  
Kate E Spies ◽  
Jennifer E Slovak
Keyword(s):  
False Positive ◽  
Point Of Care ◽  
Occult Blood ◽  
Fecal Occult Blood Testing ◽  
Normal Diet ◽  
Fecal Occult Blood ◽  
Test Set ◽  
Fecal Occult ◽  
Hydrolyzed Protein ◽  
Set Up

Objectives The aim of this study was to assess the methodology of guaiac-based fecal occult blood (FOB) testing in healthy cats, and to examine the effect of feeding selected gastrointestinal diets (canned and dry) on FOB results. Methods Stool obtained from three cats was mixed with incremental quantities of EDTA whole blood. FOB tests were performed in triplicate and interpreted at 5 mins, and at 24, 48 and 72 h post-test set-up. Ten cats were fed their normal diets, a dry hydrolyzed protein diet, a dry gastrointestinal diet and then transitioned back to their normal diet over a 7-week period. A subsequent study was repeated with similar hydrolyzed protein and gastrointestinal canned diets. Two fecal samples were tested per cat each week using human point-of-care guaiac tests. Results Ten microliters of whole feline blood could be reliably detected in feline stool at all time points evaluated. There was no evidence of an association between the dry hydrolyzed and dry gastrointestinal diets and a positive FOB test result ( P = 0.33). Cats fed a canned gastrointestinal diet had a significantly higher probability of producing a positive FOB result than when on their normal diet ( P <0.01). Feeding the canned hydrolyzed diet was not associated with an increased probability of a positive FOB test vs the normal diet ( P = 0.94). Conclusions and relevance Small amounts of blood in feline stool can be reliably and repeatedly detected as early as 5 mins post-FOB test set-up, making this a user-friendly bench-top screening test in a veterinary setting. Cats fed a single dry hydrolyzed, dry gastroenteric or canned hydrolyzed diet in this study had a low chance of false-positive FOB test results, while those fed the canned gastrointestinal diet had a significantly greater likelihood of producing false-positive results.

scholarly journals Informed choice on Pap smear still limited by lack of knowledge on the meaning of false-positive or false-negative test results

2011 ◽  
Vol 85 (2) ◽  
pp. 214-218 ◽  
Author(s):  
Ida J. Korfage ◽  
Marjolein van Ballegooijen ◽  
Brendy Wauben ◽  
J. Dik F. Habbema ◽  
Marie-Louise Essink-Bot
Keyword(s):  
False Positive ◽  
Pap Smear ◽  
False Negative ◽  
Informed Choice ◽  
Test Results ◽  
Negative Test ◽  
False Negative Test ◽  
Lack Of Knowledge

Impact of systematic false-negative test results on the performance of faecal occult blood screening

2001 ◽  
Vol 37 (7) ◽  
pp. 912-917 ◽  
Author(s):  
F. Loeve ◽  
R. Boer ◽  
G.J. van Oortmarssen ◽  
M. van Ballegooijen ◽  
J.D.F. Habbema
Keyword(s):  
False Negative ◽  
Occult Blood ◽  
Test Results ◽  
Negative Test ◽  
Faecal Occult Blood ◽  
Faecal Occult ◽  
Blood Screening ◽  
False Negative Test

scholarly journals Colorectal cancer screening and prevention: A brief review of the current guidelines and modalities

2021 ◽  
Vol 7 (2) ◽  
pp. 097-103
Author(s):  
Ashan T Hatharasinghe ◽  
Ike R Ogbu ◽  
Abdul G Gheriani ◽  
George A Trad ◽  
Andre E Manov
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Occult Blood ◽  
Fecal Occult Blood Testing ◽  
The United States ◽  
Alternative Methods ◽  
Fecal Occult Blood ◽  
Fecal Occult ◽  
Preventative Measures ◽  
Screening And Prevention

Colorectal cancer (CRC) remains a frequently addressed topic in primary care. Recent studies have been published detailing modifiable risk factors for CRC, as well as preventative measures. Providers must be up to date on screening recommendations and modalities. Colonoscopy is the preferred method of screening for CRC, and the screening recommendations in the United States were recently updated in 2020. It is also common for the practitioner to encounter patients who refuse colonoscopy but are willing to undergo alternative methods of testing. The COVID pandemic has also placed a burden on hospital resources, and colonoscopy may not be logistically feasible in some healthcare settings. Therefore, awareness of the guidelines for the various alternative modalities, along with their respective guidelines for frequency of screening is critical. This article provides a brief review of the risk factors associated with colon cancer, the screening modalities (including colonoscopy, sigmoidoscopy, CT colonography, fecal immunohistochemical testing (FIT), guaiac-based fecal occult blood testing (gFOBT), multi target stool DNA testing (MTs-DNA), and others) and the most recent screening recommendations for the general population.

‘False-positive’ and ‘false-negative’ test results in clinical urine drug testing

Bioanalysis ◽  
2009 ◽  
Vol 1 (5) ◽  
pp. 937-952 ◽  
Author(s):  
Gary M Reisfield ◽  
Bruce A Goldberger ◽  
Roger L Bertholf
Keyword(s):  
False Positive ◽  
Drug Testing ◽  
False Negative ◽  
Test Results ◽  
Negative Test ◽  
Urine Drug Testing ◽  
Urine Drug ◽  
False Negative Test
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