scholarly journals Coronavirus Disease 2019: A Comprehensive Review of Etiology, Pathogenesis, Diagnosis, and Ongoing Clinical Trials

Cureus ◽  
2020 ◽  
Author(s):  
Deepika Sarvepalli
Keyword(s):  
Clinical Trials ◽  
Comprehensive Review

scholarly journals Citicoline in Ophthalmological Neurodegenerative Disease: A Comprehensive Review

2021 ◽  
Vol 14 (3) ◽  
pp. 281
Author(s):  
Francesco Oddone ◽  
Luca Rossetti ◽  
Mariacristina Parravano ◽  
Diego Sbardella ◽  
Massimo Coletta ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Diabetic Retinopathy ◽  
Neurodegenerative Diseases ◽  
Brain Ischemia ◽  
Metabolic Pathways ◽  
Randomized Clinical Trials ◽  
Mitochondrial Dynamics ◽  
Ischemic Optic Neuropathy ◽  
Comprehensive Review ◽  
Dopaminergic Transmission

Cytidine 5’-diphosphocholine has been widely studied in systemic neurodegenerative diseases, like Alzheimer’s disease, Parkinson’s disease, and brain ischemia. The rationale for the use of citicoline in ophthalmological neurodegenerative diseases, including glaucoma, anterior ischemic optic neuropathy, and diabetic retinopathy, is founded on its multifactorial mechanism of action and the involvement in several metabolic pathways, including phospholipid homeostasis, mitochondrial dynamics, as well as cholinergic and dopaminergic transmission, all being involved in the complexity of the visual transmission. This narrative review is aimed at reporting both pre-clinical data regarding the involvement of citicoline in such metabolic pathways (including new insights about its role in the intracellular proteostasis through an interaction with the proteasome) and its effects on clinical psychophysical, electrophysiological, and morphological outcomes following its use in ophthalmological neurodegenerative diseases (including the results of the most recent prospective randomized clinical trials).

scholarly journals Antiviral, Antibacterial, Antifungal, and Antiparasitic Properties of Propolis: A Review

Foods ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 1360
Author(s):  
Felix Zulhendri ◽  
Kavita Chandrasekaran ◽  
Magdalena Kowacz ◽  
Munir Ravalia ◽  
Krishna Kripal ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Antioxidant Status ◽  
Energy Production ◽  
Mechanisms Of Action ◽  
Host Cells ◽  
Physical Barrier ◽  
Inflammatory Signaling ◽  
Replication Process ◽  
Comprehensive Review ◽  
Cellular Organelles

Propolis is a complex phytocompound made from resinous and balsamic material harvested by bees from flowers, branches, pollen, and tree exudates.Humans have used propolis therapeutically for centuries. The aim of this article is to provide comprehensive review of the antiviral, antibacterial, antifungal, and antiparasitic properties of propolis. The mechanisms of action of propolis are discussed. There are two distinct impacts with regards to antimicrobial and anti-parasitic properties of propolis, on the pathogens and on the host. With regards to the pathogens, propolis acts by disrupting the ability of the pathogens to invade the host cells by forming a physical barrier and inhibiting enzymes and proteins needed for invasion into the host cells. Propolis also inhibits the replication process of the pathogens. Moreover, propolis inhibits the metabolic processes of the pathogens by disrupting cellular organelles and components responsible for energy production. With regard to the host, propolis functions as an immunomodulator. It upregulates the innate immunity and modulates the inflammatory signaling pathways. Propolis also helps maintain the host’s cellular antioxidant status. More importantly, a small number of human clinical trials have demonstrated the efficacy and the safety of propolis as an adjuvant therapy for pathogenic infections.

scholarly journals Convalescent Plasma Therapy in COVID 19 an Indian Scenario: Comprehensive Review

2021 ◽  
pp. 453-465
Author(s):  
Shruti Vimal ◽  
Pratiksha Naval ◽  
Manoj Sawadker ◽  
Pallavi Bhomia ◽  
Neha Jadhav ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Neutralizing Antibodies ◽  
Clinical Symptoms ◽  
Scientific Data ◽  
Plasma Transfusion ◽  
Eligibility Criteria ◽  
Plasma Therapy ◽  
Comprehensive Review ◽  
Proof Of Efficacy ◽  
Indian Scenario

The recent pandemic due to Corona virus more popularly known as COVID 19 has reassessed the usefulness of historic convalescent plasma transfusion. (CPT) The CPT is one of the promising therapies in the current pandemic situation. This review was conducted to evaluate the effectiveness of CPT therapy in COVID 19 patients based on the publications reported till date. PubMed, EMBASE and Medline databases were screened up to 30 April 2021. All the records were screened as per the protocol eligibility criteria.  The main features of the studies reviewed were, convalescent plasma can reduce mortality in severely ill patients, an increase in neutralizing antibodies titre and disappearance of SARS CoV 2 RNA was observed in all the patients on CPT therapy and over all a beneficial effect on clinical symptoms after administration of CP.  Based on the review findings and the limited scientific data, CPT therapy in COVID 19 patients appear safe, clinically effective and reduces mortality. However, the need of a multicentre clinical trials, unequivocal proof of efficacy, effectiveness and the need for the standardisation of the CPT needs to be addressed immediately for the full utilisation of potential of CPT.

Dietary factors in experimental autoimmune encephalomyelitis and multiple sclerosis: A comprehensive review

2020 ◽  
pp. 135245852092395
Author(s):  
Claire Valburg ◽  
Anup Sonti ◽  
Joel NH Stern ◽  
Souhel Najjar ◽  
Asaff Harel
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trials ◽  
Animal Model ◽  
Randomized Clinical Trials ◽  
Dietary Intervention ◽  
Autoimmune Encephalitis ◽  
Dietary Factors ◽  
Comprehensive Review ◽  
Therapeutic Implications ◽  
Experimental Autoimmune

Background: Dietary intervention in multiple sclerosis carries potential therapeutic implications. While studies utilizing animal models of multiple sclerosis (MS) have demonstrated intriguing findings, well-designed clinical trials are few in number. Objective: The objective of this study is to review the animal model and clinical literature regarding dietary factors in experimental autoimmune encephalitis (EAE) and MS. Methods: This manuscript provides a comprehensive review of current animal model and clinical knowledge related to dietary factors in MS. Results: While there is currently little data for any specific diet in MS, there is growing evidence that certain dietary factors may influence the disease. Conclusions: Definitive information regarding dietary factors as a modifiable risk factor in MS will require larger randomized clinical trials.

scholarly journals Author response: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals

2019 ◽  
Author(s):  
Diana Herrera-Perez ◽  
Alyson Haslam ◽  
Tyler Crain ◽  
Jennifer Gill ◽  
Catherine Livingston ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Randomized Clinical Trials ◽  
Author Response ◽  
Medical Journals ◽  
Comprehensive Review

scholarly journals Treatment-naive CLL: lessons from phase 2 and phase 3 clinical trials

Blood ◽  
2019 ◽  
Vol 134 (21) ◽  
pp. 1796-1801 ◽  
Author(s):  
Jennifer A. Woyach
Keyword(s):  
Clinical Trials ◽  
Chronic Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Phase 2 ◽  
First Line ◽  
Phase 3 ◽  
Comprehensive Review ◽  
First Line Therapy ◽  
Line Therapy ◽  
Treatment Naïve

This article provides a comprehensive review of the first-line therapy in the rapidly evolving field of chronic lymphocytic leukemia (CLL).

scholarly journals Resveratrol and health - A comprehensive review of human clinical trials

2011 ◽  
Vol 55 (8) ◽  
pp. 1129-1141 ◽  
Author(s):  
James M. Smoliga ◽  
Joseph A. Baur ◽  
Heather A. Hausenblas
Keyword(s):  
Clinical Trials ◽  
Comprehensive Review

scholarly journals Rotula aquatica. Lour-A Review on Medicinal uses Phytochemistry and Pharmacological actions

2017 ◽  
Vol 5 (04) ◽  
pp. 04-09
Author(s):  
Baby T. Bency ◽  
K. Remya ◽  
Smitha Rani ◽  
Shebina P. Rasheed ◽  
A. K. Azeem
Keyword(s):  
Clinical Trials ◽  
Medicinal Herb ◽  
Therapeutic Effects ◽  
Preclinical Studies ◽  
Pharmacological Activities ◽  
Medicinal Uses ◽  
Comprehensive Review ◽  
The Family ◽  
Stream Beds ◽  
Anti Inflammatory

Rotula aquatic Lour is an important medicinal herb in Ayurvedic system of medicine. The plant occurs as a small branched shrub that grows characteristically among rocks and trailing over pebbles in stream beds, belonging to the family Boraginaceae and widely distributed throughout India. It is commonly called as Pasanabheda in Ayurveda. As only few studies are done on this plant, the comprehensive review presenting here will summarize regarding its Phytochemical and Pharmacological activities with the help of available and update information. Various studies indicated the antiurolithiatic, hypoglycemic, anti-inflammatory, antibacterial and anthelmintic properties of Rotula aquatica. Although the information are very encouraging and revealed some of the constituents of the plant like polyphenols and tannins as important therapeutically agents. The herb should be studied more extensively to confirm these results and reveal other potential therapeutic effects. Various traditional claims of the plant are still remain to be validated scientifically. Clinical trials for the reported preclinical studies should be performed urgently to further validate the claims on humans

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