scholarly journals Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study

Cureus ◽  
2020 ◽  
Author(s):  
Sunil B Kelgane ◽  
Jaising Salve ◽  
Prasanthi Sampara ◽  
Khokan Debnath
Keyword(s):  
Well Being ◽  
The Elderly ◽  
Controlled Study ◽  
Root Extract ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Effect of GutGard in the Management ofHelicobacter pylori: A Randomized Double Blind Placebo Controlled Study

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Sreenivasulu Puram ◽  
Hyung Chae Suh ◽  
Seung Un Kim ◽  
Bharathi Bethapudi ◽  
Joshua Allan Joseph ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Treated Group ◽  
Controlled Study ◽  
Root Extract ◽  
Double Blind ◽  
Exact Probability ◽  
Double Blind Placebo ◽  
Significant Difference ◽  
The Difference ◽  
H Pylori

A randomized, double blind placebo controlled study was conducted to evaluate the efficacy of GutGard (root extract ofGlycyrrhiza glabra) in the management ofHelicobacter pylori(H. pylori) gastric load. Participants diagnosed withH. pyloriinfection were randomly assigned to two groups to orally receive 150 mg of GutGard (n=55) or placebo (n=52) once daily for 60 days.H. pyloriinfection was assessed using13C-urea breath test (13C-UBT) at days 0, 30, and 60. Stool Antigen test (HpSA) was also performed on days 0, 30, and 60. Repeated measures of analysis of variance (RMANOVA), chi-square, and Fisher's exact probability tests were used to compare the treatment outcomes. A significant interaction effect between group and time (P=0.00) and significant difference in mean Delta Over Baseline (DOB) values between GutGard (n=50) and placebo (n=50) treated groups after intervention period were observed. On day 60, the results of HpSA test were negative in 28 subjects (56%) in GutGard treated group whereas in placebo treated group only 2 subjects (4%) showed negative response; the difference between the groups was statistically significant. On day 60, the results of13C-UBT were negative in 24 (48%) in GutGard treated group and the difference between the groups was statistically significant. The findings suggest GutGard is effective in the management ofH. pylori.

scholarly journals Safety and Efficacy of Probiotic Supplementation in Reducing the Incidence of Infections and Modulating Inflammation in the Elderly with Feeding Tubes: A Pilot, Double-Blind, Placebo-Controlled Study, “IntegPRO”

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 391
Author(s):  
Paolo Orlandoni ◽  
Nikolina Jukic Peladic ◽  
Angela Amoruso ◽  
Marco Pane ◽  
Mirko Di Rosa ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Statistical Significance ◽  
Intervention Group ◽  
Clinical Manifestations ◽  
Bowel Function ◽  
The Elderly ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Reactive Protein

A double-blind, placebo-controlled study was performed in a sample of geriatric patients treated with home enteral nutrition (HEN) to analyze the efficacy of a probiotic supplement Proxian®, which contains Lactiplantibacillus plantarum LP01 (LMG P-21021), Lentilactobacillus buchneri Lb26 (DSM 16341), Bifidobacterium animalis subsp. lactis BS01 (LMG P-21384), and is enriched with zinc (Zn) and selenium (Se), in reducing the incidence of infections and modulating inflammation. Thirty-two subjects were enrolled (mean age 79.7 ± 10.3 years), 16 in the intervention group, 16 controls. They received Proxian® or placebo for 60 days. Patients were assessed at baseline (t0) and 60 (t1) and 90 (t2) days after the beginning. Infections were detected by information regarding their clinical manifestations and the incidence of antibiotic therapy. Levels of C-reactive protein (CRP) were measured to study inflammation. Information on bowel function, nutritional status and testimonials regarding the feasibility of administration of the product were collected. Differences between the two groups in number of infections (25% intervention group vs. 44% controls), antibiotic therapies (12% vs. 37%) and modulation of CRP levels (median CRP moved from 0.95 mg/L (t0), to 0.6 (t1) and 0.7 (t2) in intervention group vs. 0.7 mg/L, 0.5 and 0.7 in controls) did not reach statistical significance. No significant changes in bowel function and nutritional status were found. Caregivers’ adherence was 100%. Results of this “IntegPRO” study showed that Proxian® is potentially safe, easy to administer and promising for further studies but it appears not to change the incidence of infections or modulate inflammation in elderly treated with HEN. The utility of Proxian® in reducing the incidence of infections and modulating inflammation in these subjects needs to be investigated by a larger multi-center clinical trial, and by using additional analyses on inflammatory markers and markers of infections.

The effects of non-viableLactobacilluson immune function in the elderly: a randomised, double-blind, placebo-controlled study

2015 ◽  
Vol 67 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Michio Maruyama ◽  
Ryoji Abe ◽  
Tomohiro Shimono ◽  
Noriyuki Iwabuchi ◽  
Fumiaki Abe ◽  
...  
Keyword(s):  
Immune Function ◽  
The Elderly ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo

Effects of Hypericum Extract on the Sleep EEG in Older Volunteers

1994 ◽  
Vol 7 (1_suppl) ◽  
pp. 39-43 ◽  
Author(s):  
H. Schulz ◽  
M. Jobert
Keyword(s):  
Tricyclic Antidepressants ◽  
Visual Analysis ◽  
Well Being ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Older Volunteers ◽  
Washout Phase ◽  
High Doses ◽  
Hypericum Extract

The effects of treatment with high doses (300 mg three times daily) of hypericum extract LI 160 on sleep quality and well-being were investigated over a 4-week period. The double-blind, placebo-controlled study was conducted with 12 older, healthy volunteers in a cross-over design, which included a 2-week washout phase between both treatment phases. A hypostatic influence of the REM sleep phases, which is typical for tricyclic antidepressants and MAO inhibitors, could not be shown for this phytopharmacon. Instead, LI 160 induced an increase of deep sleeP during the total sleeping period. This could be shown consistently in the visual analysis of the sleeping phases 3 and 4, as well as in the automatic analysis of slow-wave EEG activities. The continuity of sleep was not improved by LI 160; this was also the case for the onset of the sleep, the intermittent wake-up phases, and total sleep duration.

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