Effect of melatonin administration on sleep, behavioral disorders and hypnotic drug discontinuation in the elderly: a randomized, double-blind, placebo-controlled study

2009 ◽  
Vol 21 (1) ◽  
pp. 38-42 ◽  
Author(s):  
Cristina Garzón ◽  
Juan M. Guerrero ◽  
Oscar Aramburu ◽  
Tomás Guzmán
Keyword(s):  
Behavioral Disorders ◽  
The Elderly ◽  
Controlled Study ◽  
Drug Discontinuation ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Hypnotic Drug ◽  
Melatonin Administration

scholarly journals Safety and Efficacy of Probiotic Supplementation in Reducing the Incidence of Infections and Modulating Inflammation in the Elderly with Feeding Tubes: A Pilot, Double-Blind, Placebo-Controlled Study, “IntegPRO”

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 391
Author(s):  
Paolo Orlandoni ◽  
Nikolina Jukic Peladic ◽  
Angela Amoruso ◽  
Marco Pane ◽  
Mirko Di Rosa ◽  
...  
Keyword(s):  
Nutritional Status ◽  
Statistical Significance ◽  
Intervention Group ◽  
Clinical Manifestations ◽  
Bowel Function ◽  
The Elderly ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Reactive Protein

A double-blind, placebo-controlled study was performed in a sample of geriatric patients treated with home enteral nutrition (HEN) to analyze the efficacy of a probiotic supplement Proxian®, which contains Lactiplantibacillus plantarum LP01 (LMG P-21021), Lentilactobacillus buchneri Lb26 (DSM 16341), Bifidobacterium animalis subsp. lactis BS01 (LMG P-21384), and is enriched with zinc (Zn) and selenium (Se), in reducing the incidence of infections and modulating inflammation. Thirty-two subjects were enrolled (mean age 79.7 ± 10.3 years), 16 in the intervention group, 16 controls. They received Proxian® or placebo for 60 days. Patients were assessed at baseline (t0) and 60 (t1) and 90 (t2) days after the beginning. Infections were detected by information regarding their clinical manifestations and the incidence of antibiotic therapy. Levels of C-reactive protein (CRP) were measured to study inflammation. Information on bowel function, nutritional status and testimonials regarding the feasibility of administration of the product were collected. Differences between the two groups in number of infections (25% intervention group vs. 44% controls), antibiotic therapies (12% vs. 37%) and modulation of CRP levels (median CRP moved from 0.95 mg/L (t0), to 0.6 (t1) and 0.7 (t2) in intervention group vs. 0.7 mg/L, 0.5 and 0.7 in controls) did not reach statistical significance. No significant changes in bowel function and nutritional status were found. Caregivers’ adherence was 100%. Results of this “IntegPRO” study showed that Proxian® is potentially safe, easy to administer and promising for further studies but it appears not to change the incidence of infections or modulate inflammation in elderly treated with HEN. The utility of Proxian® in reducing the incidence of infections and modulating inflammation in these subjects needs to be investigated by a larger multi-center clinical trial, and by using additional analyses on inflammatory markers and markers of infections.

The effects of non-viableLactobacilluson immune function in the elderly: a randomised, double-blind, placebo-controlled study

2015 ◽  
Vol 67 (1) ◽  
pp. 67-73 ◽  
Author(s):  
Michio Maruyama ◽  
Ryoji Abe ◽  
Tomohiro Shimono ◽  
Noriyuki Iwabuchi ◽  
Fumiaki Abe ◽  
...  
Keyword(s):  
Immune Function ◽  
The Elderly ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo

884: Phase I, Double-Blind, Placebo-Controlled Study in Healthy Male Subjects to Investigate the Safety, Tolerability, and Pharmacokinetics of DA-8159

2004 ◽  
Vol 171 (4S) ◽  
pp. 234-234 ◽  
Author(s):  
Harin Padma-Nathan ◽  
Jae Seung Pacik ◽  
Byoung Ok Ahn ◽  
Kyung Koo Kang ◽  
Mi Young Bahng ◽  
...  
Keyword(s):  
Phase I ◽  
Controlled Study ◽  
Healthy Male ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Male Subjects
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