scholarly journals Awareness Among Parents About Pneumococcal Conjugate Vaccine in Routine Immunization Program to Prevent Pneumococcal Pneumonia in Bangladesh

Cureus ◽  
2019 ◽  
Author(s):  
Sharmin K Luies ◽  
Md. Tarek Hossain ◽  
Haribondu Sarma
Keyword(s):  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Pneumococcal Pneumonia ◽  
Routine Immunization ◽  
Immunization Program ◽  
Routine Immunization Program

scholarly journals Pneumococcal Pneumonia Requiring Hospitalization in US Children in the 13-Valent Pneumococcal Conjugate Vaccine Era

2017 ◽  
Vol 64 (12) ◽  
pp. 1699-1704 ◽  
Author(s):  
Liset Olarte ◽  
William J. Barson ◽  
Ryan M. Barson ◽  
José R. Romero ◽  
John S. Bradley ◽  
...  
Keyword(s):  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Pneumococcal Pneumonia ◽  
Us Children

scholarly journals 2717. The Impact of Pneumococcal Conjugate Vaccine in Nonbacteremic Pneumococcal Pneumonia Among Cancer Patients

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S956-S956
Author(s):  
Yeon Joo Lee ◽  
Rocco Richards ◽  
Yiqi Su ◽  
Anna Kaltsas ◽  
Genovefa Papanicolaou
Keyword(s):  
Cancer Patients ◽  
Conjugate Vaccine ◽  
Indirect Effect ◽  
Pneumococcal Conjugate Vaccine ◽  
Pneumococcal Pneumonia ◽  
Hematologic Malignancies ◽  
Childhood Immunization ◽  
Radiographic Findings ◽  
Sputum Production ◽  
The Impact

Abstract Background Invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NB-PNA) are associated with substantial morbidity and mortality in cancer patients. IPD incidence among cancer patients at MSKCC sharply declined after the introduction of routine childhood immunization with the 7-valent pneumococcal conjugate vaccine (PCV7) (1). An indirect effect of PCV on pneumococcal pneumonia incidence has also been reported (2, 3). The impact of PCV on the incidence of NB-PNA in patients with cancer has not been well studied. Methods Retrospective review of patients treated at MSKCC, 1993–2012. Unique patient visits (UPV) per year were defined as ≥1 inpatient or outpatient encounter within one calendar year. NB-PNA was defined as Isolation of Streptococcus pneumoniae from sputum or bronchoalveolar lavage (BAL); with associated symptoms (cough, sputum production, and/or fever) and radiographic findings compatible with pneumonia on chest radiograph or computerized chest tomography. NB-PNA incidence was calculated as number of NB-PNA cases per 1000 UPV. Three-time periods were examined: “before PCV7” (1993–2000), “after PCV7” (2001–2010), “after PCV13” (2011–2012). Results Of 323 NB-PNA cases, S. pneumoniae was isolated from BAL in 64 (20%) and sputum in 259 (80%). 182 (56%), 121 (37%), and 20 (7%) NB-PNA cases occurred “before PCV7,” “after PCV7,” and “after PCV13,” respectively. The incidence of NB-PNA was highest in patients with hematologic malignancies and in patients ≥65 years during all three periods (Table 1). NB-PNA incidence was lower “after PCV7” compared with “before PCV7” (0.47 vs. 0.13, P < 0.001). A non-statistically significant lower incidence of NB-PNA was noted “after PCV13” vs. “after PCV7” (0.13 vs. 0.09, P = 0.19). The highest decline of NB-PNA after PCV7 introduction was observed in patients ≥65 years (0.67 vs. 0.16, P < 0.001). Conclusion (1) The incidence of NB-PNA in adult cancer patient declined after PCV7 compared with before PCV7. (2) The reduction in NB-PNA was highest in patients ≥65 years suggesting an indirect effect from PCV7 childhood immunization. (3) A trend toward decreased incidence in NB-PNA was noted after PCV13; further surveillance is required to ascertain this trend. Disclosures All authors: No reported disclosures.

scholarly journals Indirect Effects of 10-Valent Pneumococcal Conjugate Vaccine Against Adult Pneumococcal Pneumonia in Rural Western Kenya

2019 ◽  
Vol 69 (12) ◽  
pp. 2177-2184 ◽  
Author(s):  
Godfrey M Bigogo ◽  
Allan Audi ◽  
Joshua Auko ◽  
George O Aol ◽  
Benjamin J Ochieng ◽  
...  
Keyword(s):  
Blood Culture ◽  
Conjugate Vaccine ◽  
Low Income ◽  
Indirect Effects ◽  
Pneumococcal Conjugate Vaccine ◽  
Pneumococcal Pneumonia ◽  
Low Income Countries ◽  
Western Kenya ◽  
Before And After ◽  
Rate Ratios

Abstract Background Data on pneumococcal conjugate vaccine (PCV) indirect effects in low-income countries with high human immunodeficiency virus (HIV) burden are limited. We examined adult pneumococcal pneumonia incidence before and after PCV introduction in Kenya in 2011. Methods From 1 January 2008 to 31 December 2016, we conducted surveillance for acute respiratory infection (ARI) among ~12 000 adults (≥18 years) in western Kenya, where HIV prevalence is ~17%. ARI cases (cough or difficulty breathing or chest pain, plus temperature ≥38.0°C or oxygen saturation <90%) presenting to a clinic underwent blood culture and pneumococcal urine antigen testing (UAT). We calculated ARI incidence and adjusted for healthcare seeking. The proportion of ARI cases with pneumococcus detected among those with complete testing (blood culture and UAT) was multiplied by adjusted ARI incidence to estimate pneumococcal pneumonia incidence. Results Pre-PCV (2008–2010) crude and adjusted ARI incidences were 3.14 and 5.30/100 person-years-observation (pyo), respectively. Among ARI cases, 39.0% (340/872) had both blood culture and UAT; 21.2% (72/340) had pneumococcus detected, yielding a baseline pneumococcal pneumonia incidence of 1.12/100 pyo (95% confidence interval [CI]: 1.0–1.3). In each post-PCV year (2012–2016), the incidence was significantly lower than baseline; with incidence rate ratios (IRRs) of 0.53 (95% CI: 0.31–0.61) in 2012 and 0.13 (95% CI: 0.09–0.17) in 2016. Similar declines were observed in HIV-infected (IRR: 0.13; 95% CI: 0.08–0.22) and HIV-uninfected (IRR: 0.10; 95% CI: 0.05–0.20) adults. Conclusions Adult pneumococcal pneumonia declined in western Kenya following PCV introduction, likely reflecting vaccine indirect effects. Evidence of herd protection is critical for guiding PCV policy decisions in resource-constrained areas.

scholarly journals Estimating the cost-effectiveness of an infant 13-valent pneumococcal conjugate vaccine national immunization program in China

PLoS ONE ◽  
2018 ◽  
Vol 13 (7) ◽  
pp. e0201245 ◽  
Author(s):  
Kunling Shen ◽  
Matthew Wasserman ◽  
Dongdong Liu ◽  
Yong-Hong Yang ◽  
Junfeng Yang ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
National Immunization Program ◽  
Immunization Program ◽  
National Immunization ◽  
The Cost

Complicated pneumococcal pneumonia with pleural effusion or empyema in the 13‐valent pneumococcal conjugate vaccine era

2019 ◽  
Vol 54 (5) ◽  
pp. 517-524 ◽  
Author(s):  
Alvaro Díaz‐Conradi ◽  
Sergi Hernández ◽  
Juan José García‐García ◽  
Carmen Muñoz‐Almagro ◽  
Fernando Moraga‐Llop ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Conjugate Vaccine ◽  
Pneumococcal Conjugate Vaccine ◽  
Pneumococcal Pneumonia
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