scholarly journals Carbohydrate-restricted Diet and Exercise Increase Brain-derived Neurotrophic Factor and Cognitive Function: A Randomized Crossover Trial

Cureus ◽  
2019 ◽  
Author(s):  
Amy Gyorkos ◽  
Mark H Baker ◽  
Lauren N Miutz ◽  
Deborah A Lown ◽  
Michael A Jones ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Neurotrophic Factor ◽  
Crossover Trial ◽  
Brain Derived Neurotrophic Factor ◽  
Restricted Diet ◽  
Randomized Crossover Trial ◽  
Diet And Exercise

The Brain-Derived Neurotrophic Factor Functional Polymorphism and Hand Grip Strength Impact the Association between Brain-Derived Neurotrophic Factor Levels and Cognition in Older Adults in the United States

2022 ◽  
pp. 109980042110651
Author(s):  
Tingting Liu ◽  
Hongjin Li ◽  
Yvette P. Conley ◽  
Brian A. Primack ◽  
Jing Wang ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Grip Strength ◽  
Mental Status ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Hand Grip Strength ◽  
Hand Grip ◽  
Serum Bdnf

Introduction Aging is associated with subtle cognitive decline in attention, memory, executive function, processing speed, and reasoning. Although lower brain-derived neurotrophic factor (BDNF) has been linked to cognitive decline among older adults, it is not known if the association differs among individuals with various BDNF Val66Met (rs6265) genotypes. In addition, it is not clear whether these associations vary by hand grip strength or physical activity (PA). Methods A total of 2904 older adults were included in this study using data from the Health and Retirement Study. Associations between serum BDNF and measures of cognitive function were evaluated using multivariable linear regression models stratified by Met allele status. PA and hand grip strength were added to the model to evaluate whether including these variables altered associations between serum BDNF and cognition. Results Mean age was 71.4 years old, and mean body mass index was 28.3 kg/m2. Serum BDNF levels were positively associated with higher total cognitive score (beta = 0.34, p = .07), mental status (beta = 0.16, p = .07), and word recall (beta = 0.22, p =.04) among Met carriers, while serum BDNF levels were negatively associated with mental status (beta = −0.09, p = .07) among non-Met carriers. Furthermore, associations changed when hand grip strength was added to the model but not when PA was added to the model. Conclusions The BDNF Val66Met variant may moderate the association between serum BDNF levels and cognitive function in older adults. Furthermore, such associations differ according to hand grip strength but not PA.

scholarly journals Brain-derived neurotrophic factor (BDNF) gene: a gender-specific role in cognitive function during normal cognitive aging of the MEMO-Study?

AGE ◽  
2011 ◽  
Vol 34 (4) ◽  
pp. 1011-1022 ◽  
Author(s):  
Katharine R. Laing ◽  
David Mitchell ◽  
Heike Wersching ◽  
Maria E. Czira ◽  
Klaus Berger ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Neurotrophic Factor ◽  
Cognitive Aging ◽  
Brain Derived Neurotrophic Factor ◽  
Specific Role ◽  
Bdnf Gene ◽  
Gender Specific

scholarly journals Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Yoshito Mizoguchi ◽  
Hiroshi Yao ◽  
Yoshiomi Imamura ◽  
Manabu Hashimoto ◽  
Akira Monji
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Neurotrophic Factor ◽  
Memory Impairment ◽  
Brain Derived Neurotrophic Factor ◽  
Community Dwelling ◽  
Hippocampal Atrophy ◽  
Age Related ◽  
Behavioral Memory ◽  
Community Dwelling Older Adults

Abstract The beneficial effects of brain-derived neurotrophic factor (BDNF)—a member of the neurotrophin family—on cognitive function or dementia are well established in both rodents and human beings. In contrast, little is known about the association of proBDNF—a precursor protein with opposing neuronal effects of BDNF—with cognitive function in non-demented older adults. We analyzed brain magnetic resonance imaging findings of 256 community-dwelling older adults (mean age of 68.4 years). Serum BDNF and proBDNF levels were measured by quantitative enzyme-linked immunosorbent assay. Logistic regression analysis revealed that older age, less physical activity, hippocampal atrophy, and lower BDNF levels were independently associated with memory impairment determined by the Rivermead Behavioral Memory Test. Path analysis based on structural equation modeling indicated that age, sport activity, hippocampal atrophy and BDNF but not proBDNF were individually associated with Rivermead Behavioral Memory Test scores. These findings suggest that impaired BDNF function, in addition to physical inactivity and hippocampal atrophy, is associated with age-related memory impairment. Therefore, BDNF may be a potential target for dementia prevention.

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