scholarly journals Factors Leading To Meconium Aspiration Syndrome in Term- and Post-term Neonates

Cureus ◽  
2019 ◽  
Author(s):  
Saroop Chand ◽  
Aamna Salman ◽  
Razia Mustafa Abbassi ◽  
Abdul Rehman Siyal ◽  
Fayaz M Ahmad ◽  
...  
Keyword(s):  
Meconium Aspiration Syndrome ◽  
Term Neonates ◽  
Meconium Aspiration

Meconium aspiration syndrome in term neonates with normal acid-base status at delivery: Is it different?

2001 ◽  
Vol 184 (7) ◽  
pp. 1422-1426 ◽  
Author(s):  
Sean C. Blackwell ◽  
Julie Moldenhauer ◽  
Sonia S. Hassan ◽  
Mark E. Redman ◽  
Jerrie S. Refuerzo ◽  
...  
Keyword(s):  
Meconium Aspiration Syndrome ◽  
Acid Base ◽  
Term Neonates ◽  
Meconium Aspiration ◽  
Acid Base Status ◽  
Normal Acid

scholarly journals Influence of foetal inflammation on the development of meconium aspiration syndrome in term neonates with meconium-stained amniotic fluid

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7049 ◽  
Author(s):  
Kyoko Yokoi ◽  
Osuke Iwata ◽  
Satoru Kobayashi ◽  
Kanji Muramatsu ◽  
Haruo Goto
Keyword(s):  
Amniotic Fluid ◽  
Apgar Score ◽  
Neonatal Intensive Care ◽  
Meconium Aspiration Syndrome ◽  
Univariate Logistic Regression Analysis ◽  
Term Neonates ◽  
Meconium Aspiration ◽  
Independent Variable ◽  
Male Sex ◽  
Meconium Stained Amniotic Fluid

Background Meconium-stained amniotic fluid is observed in approximately 10–15% of all deliveries; however, only 5% of neonates with meconium-stained amniotic fluid develop meconium aspiration syndrome (MAS). Although foetal distress and subsequent sympathetic stimulation have been considered as the primary upstream events of MAS, this clinical complication sometimes occurs due to other pathologies, such as intraamniotic inflammation. The aim of this study was to investigate whether the incidence of MAS is associated with the presence of funisitis and chorioamnionitis in term neonates with meconium-stained amniotic fluid. Methods Between April 2013 and March 2015, a total of 95 term neonates with meconium-stained amniotic fluid, who were hospitalized at a neonatal intensive care unit, were enrolled in the study. The placenta and umbilical cord were histopathologically examined. Clinical variables and histopathological findings associated with the incidence of MAS were studied. Results A total of 36 neonates developed MAS. Univariate logistic regression analysis revealed that a heavier birth weight, male sex, 1-min Apgar score ≤ 7, funisitis (but not chorioamnionitis), and elevated acute-phase inflammatory reaction score were associated with increased incidence of MAS (all p < 0.05). The multivariate model comprised funisitis (OR = 5.03, 95% CI [1.63–15.5], 1-min Apgar score ≤ 7 (OR = 2.74, 95% CI [1.06–7.09], and male sex (OR = 3.4, 95% CI [1.24–9.34]. Conclusion In neonates with meconium-stained amniotic fluid, funisitis, as well as low 1-min Apgar score and male sex, was identified as an independent variable for MAS development. Intraamniotic inflammation might be involved in the pathological mechanisms of MAS.

scholarly journals A Population-Based Study of Meconium Aspiration Syndrome in Neonates Born between 37 and 43 Weeks of Gestation

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
C. Fischer ◽  
C. Rybakowski ◽  
C. Ferdynus ◽  
P. Sagot ◽  
J. B. Gouyon
Keyword(s):  
Amniotic Fluid ◽  
Low Frequency ◽  
Population Based ◽  
Meconium Aspiration Syndrome ◽  
Population Based Study ◽  
Term Neonates ◽  
Meconium Aspiration ◽  
High Prevalence ◽  
Term Newborns ◽  
Meconium Stained Amniotic Fluid

The epidemiology of meconium aspiration syndrome (MAS) in term neonates is described in a population-based retrospective study of data recorded for all births from 2000 to 2007 in a French region (Burgundy). Of the 132 884 eligible term newborns, the rate of meconium-stained amniotic fluid (MSAF) was 7.93%. The prevalence of severe MAS was 0.067% in the overall population. MAS rate was 0.11% at 37-38 weeks of gestation (WG), 0.20% at 39–41 WG, and 0.49% at 42-43 WG. Factors independently associated with severe MAS were identified by a case-control study, that is, thick meconium amniotic fluid, fetal tachycardia, Apgar score ≤3 at 1 minute, and birth in a level III facility. Our results confirm the high prevalence of MSAF after 37 WG but also show the low frequency of severe MAS in a period corresponding to the new international recommendations on the management of birth with MSAF.

scholarly journals Randomized Trial of Oxygen Saturation Targets during and after Resuscitation and Reversal of Ductal Flow in an Ovine Model of Meconium Aspiration and Pulmonary Hypertension

Children ◽  
2021 ◽  
Vol 8 (7) ◽  
pp. 594
Author(s):  
Amy L. Lesneski ◽  
Payam Vali ◽  
Morgan E. Hardie ◽  
Satyan Lakshminrusimha ◽  
Deepika Sankaran
Keyword(s):  
Blood Flow ◽  
Pulmonary Hypertension ◽  
Oxygen Saturation ◽  
Ductus Arteriosus ◽  
Neonatal Resuscitation ◽  
Meconium Aspiration Syndrome ◽  
Ovine Model ◽  
Neurodevelopmental Outcomes ◽  
Meconium Aspiration ◽  
Blood Flows

Neonatal resuscitation (NRP) guidelines suggest targeting 85–95% preductal SpO2 by 10 min after birth. Optimal oxygen saturation (SpO2) targets during resuscitation and in the post-resuscitation management of neonatal meconium aspiration syndrome (MAS) with persistent pulmonary hypertension (PPHN) remains uncertain. Our objective was to compare the time to reversal of ductal flow from fetal pattern (right-to-left), to left-to-right, and to evaluate pulmonary (QPA), carotid (QCA)and ductal (QDA) blood flows between standard (85–94%) and high (95–99%) SpO2 targets during and after resuscitation. Twelve lambs asphyxiated by endotracheal meconium instillation and cord occlusion to induce MAS and PPHN were resuscitated per NRP guidelines and were randomized to either standard (85–94%) or high (95–99%) SpO2 targets. Out of twelve lambs with MAS and PPHN, six each were randomized to standard and high SpO2 targets. Median [interquartile range] time to change in direction of blood flow across the ductus arteriosus from right-to-left, to left-to-right was significantly shorter with high SpO2 target (7.4 (4.4–10.8) min) compared to standard SpO2 target (31.5 (21–66.2) min, p = 0.03). QPA was significantly higher during the first 10 min after birth with higher SpO2 target. At 60 min after birth, the QPA, QCA and QDA were not different between the groups. To conclude, targeting SpO2 of 95–99% during and after resuscitation may hasten reversal of ductal flow in lambs with MAS and PPHN and transiently increase QPA but no differences were observed at 60 min. Clinical studies comparing low and high SpO2 targets assessing hemodynamics and neurodevelopmental outcomes are warranted.

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