scholarly journals Effectiveness of Organic and Inorganic Fluoridated Dentifrice on Dental Caries Progression Among Institutionalized Geriatrics: A Randomized Intervention

Cureus ◽  
2022 ◽  
Author(s):  
Arthi Balasubramaniam ◽  
Madan Kumar PD ◽  
Kiran Iyer ◽  
Dhanraj Ganapathy
Keyword(s):  
Dental Caries ◽  
Randomized Intervention ◽  
Caries Progression

scholarly journals Apoptosis activation in human carious dentin. An immunohistochemical study

2015 ◽  
Vol 59 (3) ◽  
Author(s):  
C. Loreto ◽  
A. Psaila ◽  
G. Musumeci ◽  
S. Castorina ◽  
R. Leonardi
Keyword(s):  
Dental Caries ◽  
Mononuclear Cells ◽  
Immunohistochemical Study ◽  
Ex Vivo ◽  
Intrinsic Pathway ◽  
Dentinal Tubules ◽  
Damage Repair ◽  
Apoptosis Pathways ◽  
Caries Progression

<p>The exact mechanisms and enzymes involved in caries progression are largely unclear. Apoptosis plays a key role in dentin remodelling related to damage repair; however, it is unclear whether apoptosis in decayed teeth is activated through the extrinsic or the intrinsic pathway. This <em>ex vivo</em> immunohistochemical study explored the localization of TRAIL, DR5, Bcl-2 and Bax, the main proteins involved in apoptosis, in teeth with advanced caries. To evaluate TRAIL, DR5, Bcl-2 and Bax immunoexpressions twelve permanent carious premolars were embedded in paraffin and processed for immunohistochemistry. The results showed that TRAIL and DR5 were overexpressed in dentin and in pulp vessels and mononuclear cells; strong Bax immunostaining was detected in dilated dentinal tubules close to the lesion, and Bcl-2 staining was weak in some dentin areas under the cavity or altogether absent. These findings suggest that both apoptosis pathways are activated in dental caries. Further studies are required to gain insights into its biomolecular mechanisms. </p>

scholarly journals Biofilm formation by Streptococcus mutans and its inhibition by green tea extracts

AMB Express ◽  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sara Moataz Zayed ◽  
Mohammad Mabrouk Aboulwafa ◽  
Abdelgawad Mohamed Hashem ◽  
Sarra Ebrahim Saleh
Keyword(s):  
Dental Caries ◽  
Streptococcus Mutans ◽  
Green Tea ◽  
Biofilm Formation ◽  
Economic Value ◽  
Antibiofilm Activity ◽  
Herbal Plants ◽  
Caries Progression ◽  
Dental Plaques ◽  
Antibiofilm Agents

AbstractDental Caries is considered one of the most existing and worldwide common diseases related to the oral cavity affecting both children and adults. Streptococcus mutans is the main cariogenic microorganism involved in the dental caries progression. Natural products such as herbal plants were found to have less side effects and economic value than those of the chemically synthesized antibiofilm agents. This study aimed to isolate Streptococcus mutans from different oral samples taken from saliva and dental plaques specimens to determine their capability for biofilm formation and to evaluate the antibiofilm activity of aqueous and alcoholic green tea extracts. The results revealed that 35, 4 and 1% of recovered dental plaque isolates exhibited strong, moderate and weak biofilm formation capabilities versus 26, 12 and 2% for those recovered from saliva. Two green tea extracts (aqueous and alcoholic) were tested for their antibiofilm formation activity against some selected S. mutans isolates. The results showed that the minimum biofilm inhibitory concentrations (MBICs) of the alcoholic and aqueous green tea extracts were in the range of 3.1 to 12.5 mg/ml and 6.5 to 50 mg/ml, respectively. Accordingly, green tea extracts can be incorporated in various oral preparations for preventing dental caries.

scholarly journals Epidemiological and etiological aspects of dental caries development

2021 ◽  
Vol 38 (1) ◽  
pp. 27-34
Author(s):  
Loban' Andriivna ◽  
Faustova Oleksiivna ◽  
Chereda Volodymyrivna ◽  
Ananieva Mykolaivna
Keyword(s):  
Dental Caries ◽  
Dynamic Balance ◽  
Local Immunity ◽  
Cariogenic Bacteria ◽  
Carious Lesions ◽  
Depth Study ◽  
Caries Progression ◽  
Dental Plaques ◽  
Ecological Shifts ◽  
Oral Colonization

The infectious factor is etiological in the caries development. Early colonization of S. mutans is considered as a key point; another important caries-associated microorganism is Lactobacillus, which colonizes carious lesions later. Ecological shifts in the dental plaques against the background of weakened local immunity increase their cariogenicity and lead to the caries progression. The data obtained confirm the key importance of the oral colonization resistance in initiating dental caries and its progression. Thus, the biological status of dental plaque and the activity of cariogenic bacteria are regarded as the key mechanisms for the emergence of dental caries. Therefore, the in-depth study of oral microbial homeostasis, the factors supporting its dynamic balance, is extremely important for modern cariology that will greatly contribute to developing programs and recommendations for prevention of dental caries and its early detection in order to improve the general health of population.

scholarly journals Longitudinal Analysis of Heritability for Dental Caries Traits

2005 ◽  
Vol 84 (11) ◽  
pp. 1047-1051 ◽  
Author(s):  
W.A. Bretz ◽  
P.M. Corby ◽  
N.J. Schork ◽  
M.T. Robinson ◽  
M. Coelho ◽  
...  
Keyword(s):  
Dental Caries ◽  
Age Group ◽  
Caries Prevalence ◽  
Occlusal Surfaces ◽  
Caries Progression ◽  
Heritability Estimates ◽  
Genetic And Environmental Factors ◽  
Caries Assessment ◽  
Lesion Severity

The role of genetic and environmental factors on dental caries progression in young children was determined. A detailed caries assessment was performed in 2 examinations on 314 pairs of twins initially 1.5 to 8 years old. Surface-based caries prevalence rates (SBCPR) and lesion severity (LSI) were computed. Heritability estimates were calculated by SOLAR software. Analyses were performed on all ages combined and by age group (1.5-< 4; 4–6; > 6). Overall heritability estimates (H) of net increments SBCPRs were H = 30.0 (p < 0.0001), and were greatest for the youngest (H = 30.0) and oldest groups (H = 46.3). Overall LSI heritability estimates [H = 36.1 (p < 0.0001)] were also greatest for the youngest (H = 51.2) and oldest groups (H = 50.6). Similar findings were found for net increments of occlusal surfaces and deep dentinal lesions SBCPRs (H = 46.4–56.2). These findings are consistent with a significant genetic contribution to dental caries progression and severity in both emerging primary and permanent dentitions.

scholarly journals Predictors of Dental Caries Progression in Primary Teeth

2009 ◽  
Vol 88 (3) ◽  
pp. 270-275 ◽  
Author(s):  
A.I. Ismail ◽  
W. Sohn ◽  
S. Lim ◽  
J.M. Willem
Keyword(s):  
Dental Caries ◽  
Primary Teeth ◽  
Caries Progression

scholarly journals The Buccale Puzzle: The Symbiotic Nature of Endogenous Infections of the Oral Cavity

2002 ◽  
Vol 13 (1) ◽  
pp. 34-41 ◽  
Author(s):  
John Ruby ◽  
Jean Barbeau
Keyword(s):  
Oral Health ◽  
Dental Caries ◽  
Oral Cavity ◽  
Periodontal Diseases ◽  
Oral Disease ◽  
Continuous Change ◽  
Mutualistic Symbiosis ◽  
Normal Microflora ◽  
Caries Progression ◽  
Indigenous Microflora

The indigenous, 'normal' microflora cause the majority of localized infectious diseases of the oral cavity (eg, dental caries, alveolar abscesses, periodontal diseases and candidiasis). The same microflora also protect the host from exogenous pathogens by stimulating a vigorous immune response and providing colonization resistance. How can a microflora that support health also cause endogenous oral disease? This paradoxical host-symbiont relationship will be discussed within the dynamic of symbiosis.Symbiosis means 'life together' - it is capable of continuous change as determined by selective pressures of the oral milieu. Mutualistic symbiosis, where both the host and the indigenous microflora benefit from the association, may shift to a parasitic symbiosis, where the host is damaged and the indigenous microflora benefit. Importantly, these are reversible relationships. This microbial dynamism, called amphibiosis, is the essential adaptive process that determines the causation of endogenous oral disease by a parasitic microflora or the maintenance of oral health by a mutualistic microflora.Complex microbial consortiums, existing as a biofilm, usually provide the interfaces that initiate and perpetuate the infectious assault on host tissue. The ecology of the various oral microhabitats is critical for the development of the appropriate selecting milieux for pathogens. The microbiota associated with dental caries progression are primarily influenced by the prevailing pH, whereas periodontal diseases and pulpal infection appear to be more dependent on redox potential. Candidiasis results from host factors that favour yeast overgrowth or bacterial suppression caused by antibiotics. Oral health or disease is an adventitious event that results from microbial adaptation to prevailing conditions; prevention of endogenous oral disease can occur only when we realize that ecology is the heart of these host-symbiont relationships.

Cell Wall Ultrastructure in Three Strains of a Cariogenic Streptococcus

1971 ◽  
Vol 29 ◽  
pp. 338-339
Author(s):  
M. J. Kramer ◽  
Alan L. Coykendall
Keyword(s):  
Cell Wall ◽  
Dental Caries ◽  
Streptococcus Mutans ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Genetic Heterogeneity ◽  
Morphological Characteristics ◽  
Electron Microscopic ◽  
Dna Reassociation ◽  
Wall Ultrastructure

During the almost 50 years since Streptococcus mutans was first suggested as a factor in the etiology of dental caries, a multitude of studies have confirmed the cariogenic potential of this organism. Streptococci have been isolated from human and animal caries on numerous occasions and, with few exceptions, they are not typable by the Lancefield technique but are relatively homogeneous in their biochemical reactions. An analysis of the guanine-cytosine (G-C) composition of the DNA from strains K-1-R, NCTC 10449, and FA-1 by one of us (ALC) revealed significant differences and DNA-DNA reassociation experiments indicated that genetic heterogeneity existed among the three strains. The present electron microscopic study had as its objective the elucidation of any distinguishing morphological characteristics which might further characterize the respective strains.

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