scholarly journals Intestinal Stem Cell Marker ASCL2 is a Novel Prognostic Predictor in Esophageal Adenocarcinoma

Cureus ◽  
2022 ◽  
Author(s):  
Yukiko Shibahara ◽  
Osvaldo Espin-Garcia ◽  
James Conner ◽  
Jessica Weiss ◽  
Mathieu Derouet ◽  
...  
Keyword(s):  
Stem Cell ◽  
Esophageal Adenocarcinoma ◽  
Stem Cell Marker ◽  
Intestinal Stem Cell ◽  
Cell Marker ◽  
Prognostic Predictor

scholarly journals Intestinal Stem Cell Marker, ASCL2 Is a Novel Prognostic Predictor in Esophageal Adenocarcinoma

2021 ◽  
Author(s):  
Yukiko Shibahara ◽  
Osvaldo Espin-Garcia ◽  
James Conner ◽  
Jessica Weiss ◽  
Mathieu Derouet ◽  
...  
Keyword(s):  
Overall Survival ◽  
Stem Cell ◽  
Prognostic Factor ◽  
Esophageal Adenocarcinoma ◽  
Independent Prognostic Factor ◽  
Nodal Status ◽  
Stem Cell Marker ◽  
Intestinal Stem Cell ◽  
Cell Marker ◽  
Lgr5 Expression

Abstract Purpose: Stem cell markers play a significant role in esophageal adenocarcinoma carcinogenesis via Barrett’s esophagus; however, its utility as a prognostic biomarker has not been established. Methods: We analyzed the immunohistochemical expression of Ascl2 and Lgr5 utilizing whole slides (WS; 35 cases) and tissue microarray (TMA; 64 cases of esophageal adenocarcinoma with adjacent normal squamous epithelium, Barrett's esophagus, and dysplasia). Two pathologists semi-quantitatively scored stained slides independently/blindly, and the results were correlated with clinicopathologic factors and outcomes. Results: In WS, 51% and 57% expressed high Ascl2 and high Lgr5; in TMA, 69% and 88% expressed high Ascl2 and high Lgr5, respectively. In TMA, high Ascl2 and low Lgr5 expression significantly correlated to a higher number of involved lymph nodes (p=0.027 and p=0.0039), and Lgr5 expression significantly correlated to the pathological stage (p=0.0032). Kaplan-Meier analysis showed a negative impact of high Ascl2 expression on overall survival (OS; WS p=0.0168, TMA p=0.0276) as well as progression-free survival (PFS; WS p=0.000638, TMA p=0.0466), but not Lgr5. Multivariate Cox regression analysis revealed that Ascl2 expression is an independent prognostic factor for esophageal adenocarcinoma (OS; WS p=0.25, TMA p=0.011. PFS; WS p=0.012, TMA p=0.038). Analysis of the TCGA dataset showed that ASCL2 mRNA levels were correlated to nodal status but not overall survival.Conclusion: Intestinal stem cell marker, Ascl2 is an independent prognostic factor in esophageal adenocarcinoma. High Ascl2 levels were associated with nodal status in both immunohistochemical and mRNA expression. These findings may contribute to the development of prognosis-based subclassification of esophageal adenocarcinoma.

scholarly journals Evaluation of the Adenocarcinoma-Associated Gene AGR2 and the Intestinal Stem Cell Marker LGR5 as Biomarkers in Colorectal Cancer

2012 ◽  
Vol 13 (4) ◽  
pp. 4367-4387 ◽  
Author(s):  
Manuel Valladares-Ayerbes ◽  
Moisés Blanco-Calvo ◽  
Margarita Reboredo ◽  
María J. Lorenzo-Patiño ◽  
Pilar Iglesias-Díaz ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Stem Cell ◽  
Stem Cell Marker ◽  
Intestinal Stem Cell ◽  
Cell Marker

Expression of the putative stem cell marker Musashi-1 in Barrett's esophagus and esophageal adenocarcinoma

2010 ◽  
Vol 23 (7) ◽  
pp. 580-589 ◽  
Author(s):  
Y. V. Bobryshev ◽  
A. K. Freeman ◽  
N. K. Botelho ◽  
D. Tran ◽  
A. J. M. Levert-Mignon ◽  
...  
Keyword(s):  
Stem Cell ◽  
Barrett’S Esophagus ◽  
Esophageal Adenocarcinoma ◽  
Barrett's Esophagus ◽  
Stem Cell Marker ◽  
Cell Marker ◽  
Putative Stem Cell

Prominin1 (CD133) as an Intestinal Stem Cell Marker: Promise and Nuance

2009 ◽  
Vol 136 (7) ◽  
pp. 2051-2054 ◽  
Author(s):  
Robert K. Montgomery ◽  
Ramesh A. Shivdasani
Keyword(s):  
Stem Cell ◽  
Stem Cell Marker ◽  
Intestinal Stem Cell ◽  
Cell Marker

The Intestinal Stem Cell Marker SMOC2 Is an Independent Prognostic Marker Associated With Better Survival in Gastric Cancer

2021 ◽  
Vol 41 (7) ◽  
pp. 3689-3698
Author(s):  
CHANG LIM HYUN ◽  
SUNG JOON PARK ◽  
HYE SUNG KIM ◽  
HYUN JOO SONG ◽  
HEUNG UP KIM ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Stem Cell ◽  
Prognostic Marker ◽  
Stem Cell Marker ◽  
Intestinal Stem Cell ◽  
Cell Marker ◽  
Independent Prognostic Marker
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