scholarly journals Radiological Analysis of Gentamicin Eluting Synthetic Bone Graft Substitute Used in the Management of Patients With Traumatic Bone Voids

Cureus ◽  
2022 ◽  
Author(s):  
Ahmed Aljawadi ◽  
Thomas Naylor ◽  
Amirul Islam ◽  
Imad Madhi ◽  
Noman Niazi ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Radiological Analysis

scholarly journals 405 Radiological Analysis of Gentamicin Eluting Synthetic Bone Graft Substitute Used in The Management of Gustilo IIIB Open Fractures

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
A Aljawadi ◽  
I Madhi ◽  
T Naylor ◽  
M Elmajee ◽  
A Islam ◽  
...  
Keyword(s):  
Bone Graft ◽  
Cortical Thickness ◽  
Bone Graft Substitute ◽  
Fracture Site ◽  
Open Fractures ◽  
X Rays ◽  
Radiographic Images ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

Abstract Background Management of traumatic bone void associated with Gustilo IIIB open fractures is challenging. Gentamicin eluting synthetic bone graft substitute (Cerament-G) had been recently utilised for the management of patients with these injuries. This study aims to assess radiological signs of Cerament-G remodelling. Method Retrospective data analysis of all patients admitted to our unit with IIIB open fractures who had Cerament-G applied as avoid filler. Postoperative radiographic images of the fracture site at 6-weeks, 3-months, 6-months and at the last follow-up were reviewed. The radiological signs of Cerament-G integration, percent of void healing, and bone cortical thickness at the final follow-up were assessed. Results 34 patients met our inclusion criteria, mean age: 42 years. Mean follow-up time was 20 months. 59% of patients had excellent (>90%) void filling, 26.4% of patients had 50-90% void filling, and 14.6% had < 50% void filling. Normal bone cortical thickness was restored on AP and Lateral views in 55.8% of patients. No residual Cerement-G was seen on X-rays at the final follow-up in any of the patients. Conclusions Our results showed successful integration of Cerament-G with excellent void filling and normal cortical thickness achieved in more than half of the patients.

scholarly journals Synthetic Bone Graft Substitute for Treatment of Unicameral Bone Cysts

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Carl Nunziato ◽  
John Williams ◽  
Ronald Williams
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Bone Cysts ◽  
Synthetic Bone ◽  
Synthetic Bone Graft

scholarly journals Establishment and effects of allograft and synthetic bone graft substitute treatment of a critical size metaphyseal bone defect model in the sheep femur

Apmis ◽  
2019 ◽  
Vol 127 (2) ◽  
pp. 53-63 ◽  
Author(s):  
Werner Hettwer ◽  
Peter F. Horstmann ◽  
Sabine Bischoff ◽  
Daniel Güllmar ◽  
Jürgen R. Reichenbach ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Defect ◽  
Critical Size ◽  
Bone Graft Substitute ◽  
Defect Model ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Metaphyseal Bone

TOBRAMYCIN ELUTION FROM BONE SUBSTITUTE

2000 ◽  
Vol 04 (02) ◽  
pp. 129-134 ◽  
Author(s):  
M. W. Lawless ◽  
R. T. Laughlin ◽  
J. M. Kerpsack ◽  
D. Pisut
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Test Tube ◽  
Sterile Water ◽  
Delivery Vehicle ◽  
Synthetic Bone ◽  
Synthetic Bone Graft ◽  
Autologous Grafts ◽  
Phosphate Buffered Saline ◽  
Antibiotic Level

Purpose: To determine the rate of antibiotic elution from tobramycin-impregnated ProOsteon (Interpore) and Collagraft (Zimmer). Methods: Five samples of Collagraft and ProOsteon were impregnated with a solution containing 1.2 g of tobramycin and 10 ml of sterile water. The samples were then allowed to dry overnight. These samples were stored at 37°C in separate test tubes containing phosphate buffered saline (PBS). The solution in each test tube was removed with a pipette at hours 3, 6, 9 and 12 and days 1, 2, 3, 5, 7, 9, 11 and 13. The PBS was then replaced. The pipetted solution was sent for laboratory quantification and also used in a bioassay to determine antibiotic level. To serve as a control, two additional samples of each bone graft that were not impregnated with antibiotic were placed in separate test tubes and subjected to the same protocol. Results: The antibiotic elution rate for both ProOsteon and Collagraft was high at 3 hours [5362 and 4875 μg/ml on day 3 (3.1 μg/ml) for the Collagraft and day 7 (3.7 μg/ml) for the ProOsteon]. Effective intravenous tobramycin level is considered to be 4–6 μg/ml. Conclusion: Bone graft substitute can be used as a delivery vehicle for tobramycin. In addition, antibiotic-impregnated synthetic bone graft may potentially fill a dead space or cavitary defect without the need for large autologous grafts and does not require later removal.

scholarly journals Progressive Osteolysis After Use of Synthetic Bone Graft Substitute

Cureus ◽  
2021 ◽  
Author(s):  
Punnavit Harimtepathip ◽  
Lamar F Callaway ◽  
Margaret A Sinkler ◽  
Suash Sharma ◽  
Kelly C Homlar
Keyword(s):  
Bone Graft ◽  
Bone Graft Substitute ◽  
Synthetic Bone ◽  
Synthetic Bone Graft
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