scholarly journals Do We Need a New Approach to Cancer Biology Education for Radiation Oncology Residents?

Cureus ◽  
2021 ◽  
Author(s):  
Srinivasan Vijayakumar ◽  
Maurice King ◽  
Mary R Nittala ◽  
Roy J Duhe
Keyword(s):  
Radiation Oncology ◽  
Cancer Biology ◽  
Biology Education ◽  
New Approach

scholarly journals Classroom as Genome: Using the Tools of Genomics and Bioinformatics to Illuminate Classroom Observation Data

2019 ◽  
Vol 18 (1) ◽  
pp. es1 ◽  
Author(s):  
Robert M. Erdmann ◽  
Marilyne Stains
Keyword(s):  
Full Advantage ◽  
Real Time ◽  
Classroom Observation ◽  
Biology Education ◽  
Genomic Data ◽  
Observation Data ◽  
Detailed Data ◽  
New Approach ◽  
Downstream Analysis ◽  
Observation Protocols

Classroom observation protocols can provide an exceedingly rich form of data. However, this is a double-edged sword, as researchers often struggle to take full advantage of the detailed data outputs. In this essay, we introduce a new approach to the analysis of classroom observation data, termed “classroom as genome” (CAG). We illustrate how real-time classroom observation data and genomic data can be viewed as quite analogous, both conceptually and in terms of downstream analysis. We provide both abstract and concrete examples of how the tools of genomics and bioinformatics can be applied to classroom observation outputs. We also show how this philosophy of analysis allows for the layering of information from multiple observation protocols onto the same classroom data. The CAG approach enables biology education researchers to explore detailed patterns within observed classrooms in a highly scalable manner.

Competencies in radiation oncology: A new approach for education and training of professionals for Radiotherapy and Oncology in Europe

2012 ◽  
Vol 103 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Richard Pötter ◽  
Jesper Grau Eriksen ◽  
Andy W. Beavis ◽  
Mary Coffey ◽  
Christine Verfaillie ◽  
...  
Keyword(s):  
Radiation Oncology ◽  
Education And Training ◽  
New Approach ◽  
And Training

scholarly journals METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells

2021 ◽  
Author(s):  
Aránzazu Chamorro-Jorganes ◽  
Walid K. Sweaad ◽  
Rajesh Katare ◽  
Marie Besnier ◽  
Maryam Anwar ◽  
...  
Keyword(s):  
Cancer Biology ◽  
Limb Ischemia ◽  
Fine Tuning ◽  
Loss Of Function ◽  
New Approach ◽  
Rna Methylation ◽  
Angiogenic Potential ◽  
Protein Levels

Objective: Postnatal angiogenesis is critical in vascular homeostasis and repair. m 6 A RNA methylation is emerging as a new layer for fine-tuning gene expression. Although the contribution of the m 6 A-catalyzing enzyme, METTL3 (methyltransferase-like 3), in cancer biology has been described, its role in endothelial cell (EC) function, particularly during angiogenesis, remains unclear. Approach and Results: To characterize the relevance of METTL3 in angiogenesis regulation, we performed gain- and loss-of-function studies in vitro. We demonstrated that depletion of METTL3 in ECs reduced the level of m 6 A and impaired EC function, whereas adenovirus-mediated METTL3 overexpression increased angiogenesis. Mechanistically, we showed that METTL3 depletion in ECs decreased mature angiogenic microRNAs let-7e-5p and the miR-17-92 cluster, and increased the expression of their common target, Tsp1 (thrombospondin 1). Conversely, Ad.METTL3 increased the expression of let-7e-5p and miR-17-92 cluster and reduced protein levels of Tsp1 in ECs. Moreover, overexpression of let-7e-5p and miR-18a-5p restored the angiogenic potential of METTL3-depleted ECs. We corroborated our data in vivo employing 3 mouse models. When tested in an in vivo Matrigel plug assay, METTL3-depleted ECs had diminished ability to vascularize the plug, whereas overexpression of METTL3 promoted angiogenesis. Local Ad.METTL3 gene transfer increased postischemic neovascularization in mice with either unilateral limb ischemia or myocardial infarction. Conclusions: METTL3 regulates m 6 A RNA methylation in ECs. Endogenous METTL3 is essential for EC function and angiogenesis, potentially through influencing let-7e and miR-17-92 cluster processing. Thus, the therapeutic modulation of METTL3 should be considered as a new approach for controlling angiogenic responses in the clinical setting.

Recent Initiatives for Radiation Oncology Resident Education in Radiation and Cancer Biology

2007 ◽  
Vol 168 (2) ◽  
pp. 262-265 ◽  
Author(s):  
Joseph R. Dynlacht ◽  
Elaine M. Zeman
Keyword(s):  
Radiation Oncology ◽  
Cancer Biology ◽  
Resident Education
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