Temporal Patterns of COVID-19-Associated Pulmonary Pathology: An Autopsy Study

Pulmonary pathology in patients with AIDS: an autopsy study from Mumbai

HIV Medicine ◽

10.1046/j.1468-1293.2001.00079.x ◽

2001 ◽

Vol 2 (4) ◽

pp. 266-271 ◽

Cited By ~ 25

Author(s):

DN Lanjewar ◽

R Duggal

Keyword(s):

Autopsy Study ◽

Pulmonary Pathology

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Morbid anatomy of patients with mycobacterial infections, a cross sectional autopsy study at a tertiary Hospital in a high disease burden setting

10.21203/rs.2.13142/v1 ◽

2019 ◽

Author(s):

Dan Wamala ◽

Gunilla Kallenius ◽

Moses Joloba

Keyword(s):

Tertiary Hospital ◽

Pathological Features ◽

Pleural Effusions ◽

Autopsy Study ◽

Cross Sectional ◽

Therapeutic Implications ◽

Pulmonary Pathology ◽

Autopsy Specimens ◽

High Disease Burden ◽

Culture Positive

Abstract Background Tuberculosis is a major cause of morbidity and mortality globally. Infections caused by different mycobacteria can be clinically indistinguishable but the differences in their pathological features and mortality are unclear. Methods To evaluate the contribution of different mycobacterial pathogens to lethal mycobacterial disease and assess subsequent pathological features, we performed autopsies of 49 patients with suspected TB. Autopsy specimens were examined histologically and cultured for mycobacteria. We identified Mycobacterium tuberculosis (Mtb) isolates and non-tuberculous mycobacteria (NTM), and further genotyped the Mtb isolates. Results Mtb isolates were found in 37 patients and NTM in 12 patients. All patients had signs of caseous pneumonia and 42 patients (86%) had disease involving more than half of the lungs. Two-thirds of the patients with TB or NTM had extrapulmonary engagement in addition to pulmonary pathology. Gross pathology and histopathology were similar in TB patients and patients with NTM, except that patients with NTM had a significantly reduced tendency to cause pleural effusions. Of the Mtb isolates 55% were of the Uganda genotype, which is the predominant Mtb genotype in Uganda. This genotype was significantly more frequent in the younger patients. Conclusion In this autopsy study of patients with presumptive TB a majority of culture positive cases were caused by Mtb. In 25% of patients NTM were identified, and histopathology was similar in TB and NTM patients, although NTM patients had significantly less pleural effusions. These results suggest that NTM contribute to mortality, and that their identification is important because of the special clinical and therapeutic implications associated with NTM infections.

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The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation

Virchows Archiv ◽

10.1007/s00428-020-02881-x ◽

2020 ◽

Vol 477 (3) ◽

pp. 349-357 ◽

Cited By ~ 24

Author(s):

Hans Bösmüller ◽

Selina Traxler ◽

Michael Bitzer ◽

Helene Häberle ◽

Wolfgang Raiser ◽

...

Keyword(s):

Clinical Correlation ◽

Autopsy Study ◽

Pulmonary Pathology

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Pulmonary Pathology in Surfactant-Treated Preterm Infants with Respiratory Distress Syndrome: An Autopsy Study

Neonatology ◽

10.1159/000244343 ◽

1996 ◽

Vol 70 (1) ◽

pp. 21-28 ◽

Cited By ~ 4

Author(s):

Paolo Toti ◽

Giuseppe Buonocore ◽

Giuseppe Rinaldi ◽

Anna M. Catella ◽

Rodolfo Bracci

Keyword(s):

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Preterm Infants ◽

Distress Syndrome ◽

Autopsy Study ◽

Pulmonary Pathology

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Heart disease in patients with seropositive rheumatoid arthritis; a controlled autopsy study and review

Archives of Internal Medicine ◽

10.1001/archinte.124.6.714 ◽

1969 ◽

Vol 124 (6) ◽

pp. 714-719 ◽

Cited By ~ 15

Author(s):

T. Bonfiglio

Keyword(s):

Rheumatoid Arthritis ◽

Heart Disease ◽

Autopsy Study ◽

Seropositive Rheumatoid Arthritis

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Research Participation Experiences of Informants of Suicide and Control Cases

Crisis ◽

10.1027/0227-5910/a000025 ◽

2010 ◽

Vol 31 (5) ◽

pp. 238-246 ◽

Cited By ~ 9

Author(s):

Paul W. C. Wong ◽

Wincy S. C. Chan ◽

Philip S. L. Beh ◽

Fiona W. S. Yau ◽

Paul S. F. Yip ◽

...

Keyword(s):

Ethical Issues ◽

Research Participation ◽

Self Report ◽

Initial Contact ◽

Psychological Autopsy ◽

Autopsy Study ◽

The People ◽

And Control ◽

The Impact

Background: Ethical issues have been raised about using the psychological autopsy approach in the study of suicide. The impact on informants of control cases who participated in case-control psychological autopsy studies has not been investigated. Aims: (1) To investigate whether informants of suicide cases recruited by two approaches (coroners’ court and public mortuaries) respond differently to the initial contact by the research team. (2) To explore the reactions, reasons for participation, and comments of both the informants of suicide and control cases to psychological autopsy interviews. (3) To investigate the impact of the interviews on informants of suicide cases about a month after the interviews. Methods: A self-report questionnaire was used for the informants of both suicide and control cases. Telephone follow-up interviews were conducted with the informants of suicide cases. Results: The majority of the informants of suicide cases, regardless of the initial route of contact, as well as the control cases were positive about being approached to take part in the study. A minority of informants of suicide and control cases found the experience of talking about their family member to be more upsetting than expected. The telephone follow-up interviews showed that none of the informants of suicide cases reported being distressed by the psychological autopsy interviews. Limitations: The acceptance rate for our original psychological autopsy study was modest. Conclusions: The findings of this study are useful for future participants and researchers in measuring the potential benefits and risks of participating in similar sensitive research. Psychological autopsy interviews may be utilized as an active engagement approach to reach out to the people bereaved by suicide, especially in places where the postvention work is underdeveloped.

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